期刊
SYNLETT
卷 27, 期 4, 页码 616-620出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1560988
关键词
heterocycles; hanishin; longamide B; asymmetric synthesis; piperazinones; sulfamidates
资金
- Japan Society for the Promotion of Science [26282211]
- Keio Gijuku Academic Development Funds
- Yamada Science Foundation
- Sumitomo Foundation
- Grants-in-Aid for Scientific Research [26282211, 26102732, 26882036] Funding Source: KAKEN
We describe a simple chiral-pool synthesis of (-)-longamide B, (-)-longamide B methyl ester, and (-)-hanishin. The key feature of the total synthesis is the formation of a piperazinone from a 1,2-cyclic sulfamidate and methyl 2-pyrrolecarboxylate, which permits efficient construction of the pyrrolopiperazinone core scaffold.
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