Article
Multidisciplinary Sciences
S. Mansoori, M. Fryknas, C. Alvfors, A. Loskog, R. Larsson, P. Nygren
Summary: This study investigated the safety and efficacy of individualized dose adjusted mebendazole in patients with advanced gastrointestinal cancer. While mebendazole was found to be safe and well tolerated, all patients experienced rapid disease progression. Further exploration of mebendazole as an anticancer drug may require new approaches such as prodrug development and combination therapy with other anticancer drugs.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Premalatha Balachandran, Mahmoud Elsohly, Kevin P. Hill
Summary: CBD, a non-intoxicating phytocannabinoid, has therapeutic effects and has been approved by the FDA for the treatment of two severe forms of pediatric epilepsy. Despite its widespread use for various indications, it can interact with common medications and substances such as acetaminophen and alcohol.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Anna Bogucka-Kocka, Przemyslaw Kolodziej, Anna Makuch-Kocka, Daria Rozycka, Sebastian Rykowski, Jan Nekvinda, Bohumir Gruner, Agnieszka B. Olejniczak
Summary: This study demonstrates the activity of a series of 1,8-naphthalimide-carborane/metallacarborane conjugates against Rhabditis sp. The conjugates with cobaltacarborane showed high activity compared to other carborane conjugates.
CHEMICAL COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Lars Husmann, Hannes Gruenig, Caecilia S. Reiner, Ansgar Deibel, Bruno Ledergerber, Virginia Liberini, Stephan Skawran, Urs J. Muehlematter, Michael Messerli, Barbara Hasse, Beat Muellhaupt, Martin W. Huellner
Summary: The role of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in staging of patients with alveolar echinococcosis and its correlation with patient outcome and benzimidazole therapy duration were investigated in this study.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Daniela Hofmann, Janneke M. Brussee, Jessica D. Schulz, Jean T. Coulibaly, Marc Pfister, Jennifer Keiser
Summary: This study developed a pharmacokinetic model for albendazole and its metabolites and identified optimal doses and treatment strategies. The efficacy of albendazole varied among individuals infected with different helminth species, highlighting the need for further research.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Dario Cattaneo, Cristina Gervasoni, Alberto Corona
Summary: This paper reviews the pharmacokinetic-driven drug-drug interactions (pDDIs) involving antibiotics in ICU adult patients. Although there is a lack of specific ICU studies, several important pharmacokinetic pDDIs related to antibiotics have been identified, particularly with older antibiotics. It seems that novel molecules have a lower potential for drug interactions.
Review
Biochemistry & Molecular Biology
Stefania Chiappini, Alessio Mosca, Andrea Miuli, Francesco Maria Semeraro, Gianluca Mancusi, Maria Chiara Santovito, Francesco Di Carlo, Mauro Pettorruso, Amira Guirguis, John Martin Corkery, Giovanni Martinotti, Fabrizio Schifano, Massimo Di Giannantonio
Summary: This study reviewed the misuse of centrally acting anticholinergics, highlighting its widespread and popular nature. Healthcare professionals should be vigilant and monitor potential misusing issues due to the associated adverse effects.
Review
Neurosciences
Gaetano Zaccara, Valentina Franco
Summary: Antiseizure medications and drugs for psychiatric diseases often interact at a metabolic level, primarily through changes in the activity of cytochrome P450 enzymes. Some antiseizure medications can reduce the plasma concentrations of certain antidepressants, antipsychotics, and benzodiazepines, while newer antiseizure medications have a lower potential for these interactions. However, some newer antidepressants may inhibit CYP enzymes and increase the serum concentrations of certain antiseizure medications. Knowledge of specific CYP enzymes involved in the metabolism of individual medications and the influence of comedication on the activity of these enzymes can help anticipate clinically relevant interactions. Careful evaluation of clinical response and personalized dosage adjustments based on drug serum concentrations are recommended to manage these interactions.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Marta S. Palmeirim, Sabine Specht, Ivan Scandale, Irene Gander-Meisterernst, Monika Chabicovsky, Jennifer Keiser
Summary: Oxantel pamoate has shown high efficacy against Trichuris trichiura infections, making it a potential valuable asset in combating drug resistance.
Review
Nutrition & Dietetics
Tippawan Siritientong, Daylia Thet, Janthima Methaneethorn, Nattawut Leelakanok
Summary: This study conducted a systematic review and meta-analysis to investigate the pharmacokinetic outcomes of the interaction between supplements and antiretroviral drugs (ARV) in people living with HIV. The findings showed that coadministration of food and drugs significantly increased the time to reach maximum concentration of ARV and led to increased maximum plasma concentration of certain ARV under fed conditions. However, the area under the curve and terminal half-life were not significantly affected. Evaluating the pharmacokinetic aspects of ARV and supplement interaction is important for clinical practice, and educating patients about potential interactions is recommended.
Letter
Medicine, General & Internal
Sydney B. Ross, Emilie Bortolussi-Courval, Ryan Hanula, Todd Campbell Lee, Marnie Goodwin Wilson, Emily G. McDonald
Summary: This study examines drug-drug interactions between nirmatrelvir-ritonavir and maintenance medications in older adults with polypharmacy, using data from the MedSafer trial to identify potentially inappropriate medication use.
Article
Immunology
Alyssa R. Lindrose, Jamie A. Fraser, Patrick W. Hickey, Edward Mitre
Summary: The recent price increases in anthelmintic medications have had significant impacts on the costs borne by the US government for treating parasitic infections. There is a substantial number of anthelmintic prescriptions in the US military health care system annually, suggesting a higher number of helminth infections than previously thought.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Biochemical Research Methods
Chung-Kai Sun, Tung-Hu Tsai
Summary: This review compiles and analyzes original articles on understanding possible herb-drug interactions between traditional herbs and four major pain medications-acetaminophen, aspirin, ibuprofen, and naproxen. The most common analytical method used is high-performance liquid chromatography with an isocratic eluent system coupled to biological sample clean-up, and a wide variety of detectors have been observed. Synergistic and anti-synergistic effects were observed for acetaminophen and aspirin, while only synergistic effects have been found for naproxen. Currently, no interactions have been reported for ibuprofen.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Review
Pharmacology & Pharmacy
Andrzej Czyrski, Matylda Resztak, Pawel Swiderski, Jan Brylak, Franciszek K. Glowka
Summary: Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, characterized by a broad range of activity, but individual drugs vary considerably in safety, tolerability, pharmacokinetics profiles, and interactions with concomitant medications. Caution should be exercised when using these drugs, with an understanding of their pharmacokinetics, safety, and drug-drug interactions to ensure effective antifungal therapy. The manuscript reviews significant drug interactions of azoles with other medications, as well as with food, and highlights possible interactions during experimental therapies for the treatment of COVID-19.
Article
Biochemistry & Molecular Biology
Ivan Krecak, Ljerka Pivac, Marko Lucijanic, Marko Skelin
Summary: Polypharmacy, potentially inappropriate medications (PIMs), and drug-to-drug interactions (DDIs) are prevalent in MPN patients and may have adverse effects on health outcomes.
Review
Pharmacology & Pharmacy
Jacob Dresser, Kyle John Wilby
Summary: This study compared the incidence and types of adverse effects between 3 recommended treatment options for gonorrhea and the incidence of injection site pain between single-dose intramuscular ceftriaxone and gentamicin. The results showed that there were no significant differences in adverse effects between the treatment options and injection site pain was common but similar between groups. The use of single-dose cefixime, ceftriaxone, and gentamicin-based regimens for gonorrhea appears to be safe and acceptable for practice.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Maguy Saffouh El Hajj, Myriam Jaam, Saba Abdal Salam Sheikh Ali, Rana Saleh, Ahmed Awaisu, Bridget Paravattil, Kyle John Wilby
Summary: Tobacco use is a major preventable cause of morbidity and mortality globally. This study aimed to identify and critically assess the quality of existing clinical practice guidelines for tobacco cessation. The highest quality guideline was from the National Institute for Health and Care Excellence (NICE), while the lowest quality was from the Japanese Circulation Society Joint Working Group. Analysis showed that the clarity of presentation had the highest average quality score, while rigour of development and applicability had the lowest average quality scores.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Article
Public, Environmental & Occupational Health
Kyle John Wilby, Bridget Paravattil
Summary: The concept of mental workload is largely associated with cognitive load theory, describing three types of load in assessment tasks. Studies show that high intrinsic and extraneous load in assessments may interfere with assessors' attention and working memory, leading to poorer quality assessment. Therefore, reducing these loads within assessment tasks is crucial for enhancing assessment quality, especially in pharmacy education.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Karen M. Whitfield, Kyle John Wilby
Summary: Developing grit, motivation, and resilience within the pharmacy workforce has become increasingly important, with resilience identified as a strategy to combat burnout in healthcare workers facing a rapidly changing and challenging work environment. The overlap of emotional balance and physical and mental strength, as well as finding purpose and meaning, are key components in developing resilience in healthcare professionals.
Article
Pharmacology & Pharmacy
Karen Whitfield, Vibhuti Arya, Zubin Austin, Dalia Bajis, Catriona Bradley, Bronwyn Clark, Betty Exintaris, Kirsten Galbraith, Maguy Saffouh El Hajj, Kat Hall, Louise Hughes, Sue Kirsa, Catherine Langran, Efi Mantzourani, Kyle John Wilby, Sarah Willis
Summary: A resilient pharmacy workforce is crucial for long-term sustainability and facing challenges. Developing resilience involves addressing burnout issues among pharmacists and students, and collaborating on education, research, and practice initiatives. Through international collaborations and focus on community, the collective power can be harnessed for future endeavors.
Review
Pharmacology & Pharmacy
Kyle J. Wilby
Summary: Tuberculosis remains a major infectious disease burden globally. Bedaquiline, an orally administered drug, is effective in treating multi-drug-resistant tuberculosis. This review examines the pharmacokinetics of bedaquiline and highlights the need for further research on exposure-response relationships, optimal dosing, and guidance for co-administration with other drugs.
CLINICAL PHARMACOKINETICS
(2022)
Review
Health Care Sciences & Services
Alla El-Awaisi, Myriam Jaam, Kyle John Wilby, Kerry Wilbur
Summary: Despite the emphasis on interprofessional education, there is a lack of evidence and rigorous assessment methods for evaluating student-learning outcomes. This systematic review highlights the need for both summative assessment and training for faculty assessors and students in order to improve assessment practices and equip students with necessary skills.
JOURNAL OF INTERPROFESSIONAL CARE
(2022)
Review
Pharmacology & Pharmacy
Tarik Al-Diery, Amy Theresa Page, Jacinta Lee Johnson, Steven Walker, Diana Sandulache, Kyle John Wilby
Summary: The article describes the evidence for the effectiveness of a post-graduate experiential learning program, such as a foundational pharmacy residency, in supporting early-career pharmacists' competency development in education, leadership, and innovation. The study found that residency programs have successfully fostered these skills through various activities and courses, although the extent of success varies.
JOURNAL OF PHARMACY PRACTICE AND RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Samuel E. Villemure, Kevin Astle, Tam Phan, Kyle J. Wilby
Summary: This scoping review aimed to identify minority stress processes experienced by sexual and gender minority individuals in pharmacies and with pharmacists. The study found that distal stress processes included perceived stigma, negative attitudes of pharmacy staff, and a lack of awareness of population needs, while proximal stress processes included concealment, expectation of rejection, and internalized self-dislike. Coordinated efforts are needed among professional stakeholders to reduce these stress processes and ensure accessible pharmacy-based services for all individuals.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Carlo A. Marra, Ina Donat, Michaela Lee, Hanne Roberti, Tim Sue, Martin Au, Denise Lam, Kyle J. Wilby
Summary: This study investigates the use of micro-credentialing in postgraduate study in pharmacy practice. Through an online survey of practicing and intern pharmacists in New Zealand, it was found that there is a high level of support for microcredentials as an alternative to traditional courses. Additionally, learners prioritize their interests, skill development, and career advancement.
INTERNATIONAL JOURNAL OF PHARMACY PRACTICE
(2022)
Article
Education, Scientific Disciplines
Mariam Ghabour, Caroline Morris, Kyle John Wilby, Alesha J. Smith
Summary: This study compared pharmacist prescribing training models in the UK, Australia, and Canada, and identified differences in funding, practice models, training courses, delivery methods, assessment, professional development, and barriers to enrolment. The study highlights the under-utilisation of pharmacist prescribing in many countries and suggests that standardisation could improve uptake. However, there is currently no unified international system or curriculum for pharmacist prescribing courses.
PHARMACY EDUCATION
(2023)
Article
Pharmacology & Pharmacy
Connor Booker, Andrea L. Murphy, Jennifer E. E. Isenor, Tasha D. D. Ramsey, Alesha J. J. Smith, Andrea Bishop, Deborah V. V. Kelly, Lisa Woodill, Greg Richard, Kyle John Wilby
Summary: This study investigated the pharmacists' acceptance of pharmacist prescribing for pre-exposure prophylaxis (PrEP) in Nova Scotia. Pharmacists showed a positive attitude towards pharmacist prescribing for PrEP, but also expressed concerns about workload, time cost, education and training, and laboratory testing and reimbursement.
CANADIAN PHARMACISTS JOURNAL
(2023)
Article
Primary Health Care
Mariam Ghabour, Caroline Morris, Kyle Wilby, Alesha Smith
Summary: This study aimed to explore the knowledge and perceptions of New Zealand registered pharmacists on pharmacist prescribing roles, courses, and the barriers and facilitators to course uptake. The findings revealed that most pharmacists believed that pharmacist prescribing would improve healthcare delivery in New Zealand. The main barriers to course uptake included funding, lack of institutional support, inadequate pharmacological/pharmaceutical knowledge, and difficulties in finding medical supervisors.
JOURNAL OF PRIMARY HEALTH CARE
(2023)
Article
Pharmacology & Pharmacy
Kyle John Wilby, Dianne Cox, Anne Marie Whelan, Vibhuti Arya, Heidi Framp, Susan Mansour
Summary: This study examined the presence of a hidden curriculum in case-based learning materials in pharmacy education. The findings suggest that the cases lack appropriate representation of underrepresented populations, reinforcing biases and stereotypes. Educators should prioritize diversity and ensure appropriate representation across the curriculum.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Kyle John Wilby, Emily K. Black, Arcelio Benetoli, Bridget Paravattil
Summary: The goal of this project was to develop research-informed curricular content for pharmacy students to raise their awareness of global citizenship. The study found that students were able to generate local responses to global problems, reducing the impact of political, environmental, and health-related issues.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)