期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 10, 期 1, 页码 41-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.04.001
关键词
Anti-tubercular; 2D QSAR; 5-Methylpyrazine-2-carbohydrazide; Mycobacterium tuberculosis
A simple synthetic methodology was employed for synthesis of series of 5-methylpyrazine- 2-carbohydrazide derivatives (PM series). In vitro anti-tubercular activity was evaluated against Mycobacterium tuberculosis (H(37)Rv) in Middle brook 7H-9 broth medium. Amongst synthesized compounds, seven compounds showed remarkable anti-tubercular activity. The 2-D QSAR illustrates the design PM series of compounds as potential anti-tubercular scaffolds that can be further optimized to improve the activity. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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