Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations

The smallest natural high-active luciferase: Cloning and characterization of novel 16.5-kDa luciferase from copepod Metridia longa

(2015) Svetlana V. Markova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bacterial expression and re-engineering of Gaussia princeps luciferase and its use as a reporter protein

(2015) Nan Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

(2015) Ryo Nishihara et al.   CHEMICAL COMMUNICATIONS

Recent progress in luminescent proteins development

(2015) Kenta Saito et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

(2015) Richa Goel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Concise Synthesis of v-Coelenterazines

(2015) Takamitsu Hosoya et al.   ORGANIC LETTERS

The Reaction Mechanism of Calcium-Activated Photoprotein Bioluminescence

(2015) Takashi Hirano   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Exploiting in vitro and in vivo bioluminescence for the implementation of the three Rs principle (replacement, reduction, and refinement) in drug discovery

(2014) Elisa Michelini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Bioluminescent properties of obelin and aequorin with novel coelenterazine analogues

(2014) Ronan Gealageas et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Functional artificial luciferases as an optical readout for bioassays

(2014) Sung Bae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hybrid QM/MM Simulations of the Obelin Bioluminescence and Fluorescence Reveal an Unexpected Light Emitter

(2014) Shufeng Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Strategies for Large-Scale Synthesis of Coelenterazine for in Vivo Applications

(2014) Tej Shrestha et al.   SYNTHESIS-STUTTGART

Identification of 3-enol sulfate of Cypridina luciferin, Cypridina luciferyl sulfate, in the sea-firefly Cypridina (Vargula) hilgendorfii

(2014) Mitsuhiro Nakamura et al.   TETRAHEDRON

Efficient synthesis and antioxidant activity of coelenterazine analogues

(2014) Yueting Lu et al.   TETRAHEDRON LETTERS

A Panel of Trypanosoma brucei Strains Tagged with Blue and Red-Shifted Luciferases for Bioluminescent Imaging in Murine Infection Models

(2014) Nick Van Reet et al.   PLoS Neglected Tropical Diseases

Directed Molecular Evolution Reveals Gaussia Luciferase Variants with Enhanced Light Output Stability

(2013) M. Hannah Degeling et al.   ANALYTICAL CHEMISTRY

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: The mutated catalytic 19kDa component of Oplophorus luciferase

(2013) Satoshi Inouye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Creation of Artificial Luciferases for Bioassays

(2013) Sung Bae Kim et al.   BIOCONJUGATE CHEMISTRY

Evaluating reporter genes of different luciferases for optimizedin vivobioluminescence imaging of transplanted neural stem cells in the brain

(2013) Laura Mezzanotte et al.   Contrast Media & Molecular Imaging

Chemiluminescent 2,6-diphenylimidazo[1,2-a]pyrazin-3(7H)-ones: a new entry to Cypridina luciferin analogues

(2013) Yuki Ishii et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

A Novel Catalytic Function of Synthetic IgG-Binding Domain (Z Domain) from Staphylococcal Protein A: Light Emission with Coelenterazine

(2013) Satoshi Inouye et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Novel functional Renilla luciferase mutant provides long-term serum stability and high luminescence activity

(2013) Woo Chul Song et al.   PROTEIN EXPRESSION AND PURIFICATION

2-alkoxypropenals as synthetic equivalents of methylglyoxal in the synthesis of heterocycles

(2013) N. A. Keiko et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

Advances in Fluorescence and Bioluminescence Imaging

(2012) Takeaki Ozawa et al.   ANALYTICAL CHEMISTRY

Bioluminescence based in vivo screening technologies

(2012) Madhura Kelkar et al.   CURRENT OPINION IN PHARMACOLOGY

Chemical Synthesis of Coelenterazine and Its Analogs: New Route toward Four Segment-Couplings

(2012) Minoru Isobe et al.   HETEROCYCLES

Chemiluminescence of Coelenterazine and Fluorescence of Coelenteramide: A Systematic Theoretical Study

(2012) Shu-Feng Chen et al.   Journal of Chemical Theory and Computation

Enzymatic activity of albumin shown by coelenterazine chemiluminescence

(2012) N Vassel et al.   LUMINESCENCE

A Water-Soluble Coelenterazine for Sensitive In Vivo Imaging of Coelenterate Luciferases

(2012) Danielle Morse et al.   MOLECULAR THERAPY

Substrate Cooperativity in Marine Luciferases

(2012) George Tzertzinis et al.   PLoS One

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines

(2012) Satoshi Inouye et al.   PROTEIN EXPRESSION AND PURIFICATION

New red-shifted coelenterazine analogues with an extended electronic conjugation

(2012) Germano Giuliani et al.   TETRAHEDRON LETTERS

Superluminescent Variants of Marine Luciferases for Bioassays

(2011) Sung Bae Kim et al.   ANALYTICAL CHEMISTRY

Seeing the Light: Luminescent Reporter Gene Assays

(2011) Loren J. Miraglia et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Application of new semisynthetic aequorins with long half-decay time of luminescence to G-protein-coupled receptor assay

(2010) Satoshi Inouye et al.   ANALYTICAL BIOCHEMISTRY

Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology

(2010) Natasha Thorne et al.   CHEMISTRY & BIOLOGY

Bioluminescence assays: multicolor luciferase assay, secreted luciferase assay and imaging luciferase assay

(2010) Yoshihiro Nakajima et al.   Expert Opinion on Drug Discovery

Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases

(2010) Takahiro Kimura et al.   JOURNAL OF GENE MEDICINE

Bioluminescence in the Ocean: Origins of Biological, Chemical, and Ecological Diversity

(2010) E. A. Widder   SCIENCE

Suzuki–Miyaura coupling for general synthesis of dehydrocoelenterazine applicable for 6-position analogs directing toward bioluminescence studies

(2010) Wong Phakhodee et al.   TETRAHEDRON

GFP: Lighting Up Life (Nobel Lecture)

(2009) Martin Chalfie   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)

(2009) Roger Y. Tsien   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Green Fluorescent Protein (GFP) (Nobel Lecture)

(2009) Osamu Shimomura   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioluminescence in the Sea

(2009) Steven H.D. Haddock et al.   Annual Review of Marine Science

Biosynthesis of coelenterazine in the deep-sea copepod, Metridia pacifica

(2009) Yuichi Oba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro and in vivo studies of 6,8-(diaryl)imidazo[1,2-a]pyrazin-3(7H)-ones as new antioxidants

(2009) Frederic De Wael et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dehydrocoelenterazine is the Organic Substance Constituting the Prosthetic Group of Pholasin

(2009) Eiko Tanaka et al.   CHEMBIOCHEM

Green fluorescent protein: structure, folding and chromophore maturation

(2009) Timothy D. Craggs   CHEMICAL SOCIETY REVIEWS

The structure and function of fluorescent proteins

(2009) Vedangi Sample et al.   CHEMICAL SOCIETY REVIEWS

Based on a review of the data, use of the term ‘cypridinid’ solves the Cypridina/Vargula dilemma for naming the constituents of the luminescent system of ostracods in the family Cypridinidae

(2009) James G. Morin   LUMINESCENCE

A red-shifted Renilla luciferase for transient reporter-gene expression

(2009) Andreas Markus Loening et al.   NATURE METHODS

Regio- and Chemoselective Multiple Functionalization of Chloropyrazine Derivatives. Application to the Synthesis of Coelenterazine

(2009) Marc Mosrin et al.   ORGANIC LETTERS

Aequorin variants with improved bioluminescence properties

(2009) E. Dikici et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Bioluminescence of the arm light organs of the luminous squid Watasenia scintillans

(2008) Katsunori Teranishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pholasin luminescence is enhanced by addition of dehydrocoelenterazine

(2008) Masaki Kuse et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Bioluminescence in analytical chemistry and in vivo imaging

(2008) Aldo Roda et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY