期刊
TETRAHEDRON LETTERS
卷 56, 期 22, 页码 2896-2901出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.04.076
关键词
Fused nitrogen heterocycles; Oxidative cyclisation; Chloramine T; Intramolecular reaction; One pot synthesis
A facile and expedient one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine derivatives from 2-chloro-3-hydrazinylpyrazine and aldehydes is described using chloramine T trihydrate as a safe and convenient electrocyclisation (oxidising) agent. The presence of the chloro group on pyrazine enabled us to access versatile new synthetic scaffolds by easy diversification using palladium catalysed Suzuki-Miyaura and Sonogashira cross coupling reactions. The products are obtained in high yields in short reaction time under mild conditions without the need for chromatographic purification. (C) 2015 Elsevier Ltd. All rights reserved.
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