A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone

Seven membered heterocyclic Azepine and its derivatives have great pharmacological and therapeutic implications. In this review, the literature of the last fifty years has been exploited for the synthesis, reaction, and biological properties of these seven-member heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five or six-membered compounds using various methods such as thermally, photo-chemically, and microwave irradiation. The systematically designed schemes involve the synthesis of different derivatives of azepine, azepinone, azepane, etc., using similar moieties by various researchers. However, there is much work yet to be done in the biological section, as it is not explored and reported in the literature; therefore, N-containing seven-membered heterocycles still have much scope for the researchers.

Automated summary

Seven-membered heterocyclic azepine and its derivatives have significant pharmacological and therapeutic implications, but there is still much progress to be made in the biological section. Research in the past fifty years has focused on synthesis, reaction, and biological properties, with mechanisms involving ring expansion of five or six-membered compounds using various methods. Further exploration and reporting in the biological field are needed, indicating that there is still ample scope for researchers in N-containing seven-membered heterocycles.