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Synthesis of 8a-Chlorotetrahydropyrrolo[1,2-a]pyrazine-1,6,7-(2H)-triones from 3-Methylidenepiperazin-2-ones and Oxalyl Chloride

期刊

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
卷 54, 期 5, 页码 807-809

出版社

MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070428018050263

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资金

  1. Russian Ministry of Education and Science [4.6774.2017/8.9, 4.5894.2017/7.8]
  2. Council of grants of the President of the Russian Federation [MK-1657.2017.3]
  3. Russian Foundation for Basic Research [16-43-590613]

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(Z)-1-Aryl-3-(2-aryl-2-oxoethylidene)piperazin-2-ones react with oxalyl chloride at cooling with the formation of (Z)-2-aryl-8-[hydroxy(aryl)methylidene]-8D degrees-chlorotetrahydropyrrolD 3/4 [1,2-a]pyrazine-1,6,7(2H)-triones. At heating HCl is eliminated from them to produce 8-aroyl-3,4-dihydropyrrolD 3/4 [1,2-D degrees]pyrazine- 1,6,7(2H)-triones.

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