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Synthesis of Fluoroquinoxalin-2(1H)-one Derivatives Containing Substituents in the Pyrazine and Benzene Fragments

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RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
卷 53, 期 1, 页码 90-95

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MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S107042801701016X

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  1. Russian Foundation for Basic Research [14-03-01 033]
  2. Ministry of Education and Science of the Russian Federation [4.1626.2014/K]

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6,7-Difluoroquinoxalin-2-one reacted with indoles, 5,5-dimethylcyclohexane- 1,3-dione, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, resorcinol, and pyrogallol on heating in acetic acid to give products of hydrogen substitution in the heterocyclic fragment. Heating of 6,7-difluoro-3-(1H-indol-3-yl) quinoxalin2(1H)-ones with N-methylpiperazine gave the corresponding 7-(4-methylpiperazin-1-yl) derivatives.

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