Could Alzheimer’s Disease Originate in the Periphery and If So How So?

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

(2018) Gerwyn Morris et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

(2018) Leonardo Iaccarino et al.   NeuroImage-Clinical

Dysfunction of the Fusion of Pre-Synaptic Plasma Membranes and Synaptic Vesicles Caused by Oxidative Stress, and its Prevention by Vitamin E

(2018) Masaya Arai et al.   JOURNAL OF ALZHEIMERS DISEASE

Combinatorial Markers of Mild Cognitive Impairment Conversion to Alzheimer's Disease - Cytokines and MRI Measures Together Predict Disease Progression

(2018) Simon J. Furney et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood

(2018) Katie Lunnon et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease

(2018) Yong-Xin Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Overexpression of Heme Oxygenase 1 Causes Cognitive Decline and Affects Pathways for Tauopathy in Mice

(2018) Dayong Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

(2017) Ayano Mise et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations in the Peripheral Immune System in Dementia

(2017) Mandy Busse et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

(2017) Lan Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

(2017) Yi Jayne Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

(2017) Qian Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble TREM2 induces inflammatory responses and enhances microglial survival

(2017) Li Zhong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

(2017) Yuki Ozaki et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

(2017) G. Morris et al.   MOLECULAR NEUROBIOLOGY

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

(2017) Annika Sommer et al.   Molecular Neurodegeneration

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer’s disease dementia

(2017) K Chiotis et al.   MOLECULAR PSYCHIATRY

Epidemiologie und Ursachen der Parkinson-Erkrankung

(2017) C. M. Lill et al.   NERVENARZT

Brain tau deposition linked to systemic causes of death in normal elderly

(2017) Keith A. Josephs et al.   NEUROBIOLOGY OF AGING

Tau positron emission tomography using [ 18 F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease

(2017) Jae Myeong Kang et al.   NEUROBIOLOGY OF AGING

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

A model of the mitochondrial basis of bipolar disorder

(2017) Gerwyn Morris et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

(2017) Diego Mastroeni et al.   PLoS One

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

(2017) Mati Mann et al.   Nature Communications

Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway

(2017) Yujun Xu et al.   Scientific Reports

Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation

(2017) Sannette C. Hall et al.   Scientific Reports

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

(2017) Li Zhong et al.   Frontiers in Aging Neuroscience

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer’s and Vascular Disease

(2017) Michela Guglielmotto et al.   Frontiers in Aging Neuroscience

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients

(2017) Aurélie Le Page et al.   Frontiers in Immunology

Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain

(2017) Yuhai Zhao et al.   Frontiers in Immunology

Involvement of ApoE E4 and H63D in Sporadic Alzheimer's Disease in a Folate-Supplemented Ontario Population

(2017) Maire Percy et al.   JOURNAL OF ALZHEIMERS DISEASE

Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

(2017) Anis Larbi et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

(2017) Sandro Altamura et al.   JOURNAL OF ALZHEIMERS DISEASE

Vitamin B12 Levels in Alzheimer's Disease: Association with Clinical Features and Cytokine Production

(2017) Antonis Politis et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Regional Selectivity of rab5 and rab7 Protein Upregulation in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Stephen D. Ginsberg et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

Direct recognition of LPS drive TLR4 expressing CD8+ T cell activation in patients with rheumatoid arthritis

(2017) Archana Tripathy et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

(2016) Hans-Ulrich Klein et al.   ACTA NEUROPATHOLOGICA

STAT3 SIGNALING REFEREES MICROGLIAL AMYLOID CLEARANCE IN ALZHEIMER’S DISEASE

(2016) Kevin R. Doty et al.   Alzheimers & Dementia

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

(2016) M.T. Ferretti et al.   BRAIN BEHAVIOR AND IMMUNITY

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lymphocytes in Alzheimer's Disease Pathology: Altered Signaling Pathways

(2016) Noemí Esteras et al.   Current Alzheimer Research

The Putative Use of Lithium in Alzheimer's Disease

(2016) Gerwyn Morris et al.   Current Alzheimer Research

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

(2016) Karen J Bryson et al.   CURRENT OPINION IN PHARMACOLOGY

The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome

(2016) Gerwyn Morris et al.   CURRENT PHARMACEUTICAL DESIGN

Microglial Priming and Alzheimer’s Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

(2016) Lianne Hoeijmakers et al.   Frontiers in Human Neuroscience

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

(2016) M. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Lymphocytes in Alzheimer's disease

(2016) Zoltan Fehervari   NATURE IMMUNOLOGY

Determinants of iron accumulation in the normal aging brain

(2016) Lukas Pirpamer et al.   NEUROBIOLOGY OF AGING

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain

(2016) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

Dysfunction of NMDA receptors in Alzheimer’s disease

(2016) Yan Zhang et al.   NEUROLOGICAL SCIENCES

Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

(2016) Sandro Dá Mesquita et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer’s disease in Caucasian, and Asian populations

(2016) Hao Huang et al.   NEUROSCIENCE LETTERS

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration

(2016) A E Hall et al.   Cell Death & Disease

MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc

(2016) Rana Ahmed Youness et al.   Oncology Letters

Common DNA methylation alterations of Alzheimer’s disease and aging in peripheral whole blood

(2016) Hongdong Li et al.   Oncotarget

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

(2016) Bing Gong et al.   Frontiers in Molecular Neuroscience

Imaging of Leukocyte Trafficking in Alzheimer’s Disease

(2016) Enrica Pietronigro et al.   Frontiers in Immunology

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease

(2016) Gérard N. Bischof et al.   Annals of Clinical and Translational Neurology

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS)

(2016) Stefano Caserta et al.   Scientific Reports

Adaptive immunity against gut microbiota enhances apoE-mediated immune regulation and reduces atherosclerosis and western-diet-related inflammation

(2016) Diego Saita et al.   Scientific Reports

Influence of apolipoprotein E isoform on microRNA transcriptome in macrophages

(2015) S. Czauderna et al.   ATHEROSCLEROSIS

The blood–brain barrier endothelium: a target for pro-inflammatory cytokines: Figure 1

(2015) Keith D. Rochfort et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An overview of molecular basis of iron metabolism regulation and the associated pathologies

(2015) Bruno Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

(2015) Gerwyn Morris et al.   BMC Medicine

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

(2015) Gerwyn Morris et al.   BMC Medicine

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer’s disease

(2015) Zhen Fan et al.   BRAIN

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue

(2015) Kurt Lucas et al.   CNS & Neurological Disorders-Drug Targets

Impacts of oxidative stress on acetylcholinesterase transcription, and activity in embryos of zebrafish (Danio rerio) following Chlorpyrifos exposure

(2015) Gabriela Rodríguez-Fuentes et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

(2015) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

(2015) Gero Lueg et al.   NEUROBIOLOGY OF AGING

Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease

(2015) Atsushi Sasaki et al.   NEUROGENETICS

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?

(2015) L.-F. Lue et al.   NEUROSCIENCE

Expression profile analysis of microRNAs and downregulated miR-486-5p and miR-30a-5p in non-small cell lung cancer

(2015) JIANJIE ZHU et al.   ONCOLOGY REPORTS

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells

(2015) Yu-Fan Chuang et al.   PLoS One

TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer’s Disease and Schizophrenia

(2015) Yoko Mori et al.   PLoS One

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function

(2015) Juhyun Song et al.   Frontiers in Aging Neuroscience

Epigenetic Alterations in Alzheimer’s Disease

(2015) Jose V. Sanchez-Mut et al.   Frontiers in Behavioral Neuroscience

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Endogenous Interferon-β-Inducible Gene Expression and Interferon-β-Treatment Are Associated with Reduced T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

(2015) Lars Börnsen et al.   PLoS One

Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance

(2015) Christian-Alexandre Castellano et al.   PLoS One

APOLIPOPROTEIN E GENOTYPE AND OXIDATIVE STRESS IN PERIPHERAL LYMPHOCYTES OF PATIENTS WITH ALZHEIMER'S DISEASE

(2014) Jolanta Dorszewska et al.   Alzheimers & Dementia

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

(2014) Kenneth Maiese   ANNALS OF MEDICINE

Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization

(2014) Li Zhang et al.   Autophagy

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases

(2014) E. V. Stelmashook et al.   BIOCHEMISTRY-MOSCOW

Is Alzheimer's disease a systemic disease?

(2014) Jill K. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PP2A inactivation by ROS accumulation

(2014) S. Nakahata et al.   BLOOD

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

(2014) Lih-Fen Lue et al.   BRAIN PATHOLOGY

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

(2014) I. Pra et al.   Current Neuropharmacology

Oxidative and Nitrosative Stress and Immune-inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

(2014) Gerwyn Morris et al.   Current Neuropharmacology

Corrigendum to “Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters” [FEBS Lett. 588 (2014) 795-800]

(2014) Baian Chen et al.   FEBS LETTERS

Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid

(2014) James Everett et al.   INORGANIC CHEMISTRY

TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation

(2014) W. Cui et al.   JOURNAL OF IMMUNOLOGY

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

(2014) Janko Nikolich-Žugich   JOURNAL OF IMMUNOLOGY

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway

(2014) Zhong-Ming Qian et al.   MOLECULAR NEUROBIOLOGY

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

Diazoxide Pretreatment Prevents Aβ1–42 Induced Oxidative Stress in Cholinergic Neurons Via Alleviating NOX2 Expression

(2014) Qingxi Fu et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Differential Pro-Inflammatory Responses of Astrocytes and Microglia Involve STAT3 Activation in Response to 1800 MHz Radiofrequency Fields

(2014) Yonghui Lu et al.   PLoS One

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications

(2014) Jijun Chen   REVIEWS IN THE NEUROSCIENCES

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

(2014) Ricardo Cabezas et al.   Frontiers in Cellular Neuroscience

Gut Microbiota as an Epigenetic Regulator: Pilot Study Based on Whole-Genome Methylation Analysis

(2014) Himanshu Kumar et al.   mBio

Alzheimer’s disease causation by copper toxicity and treatment with zinc

(2014) George J. Brewer   Frontiers in Aging Neuroscience

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

GSK-3β, a pivotal kinase in Alzheimer disease

(2014) María Llorens-Marítin et al.   Frontiers in Molecular Neuroscience

HFE gene variants, iron, and lipids: a novel connection in Alzheimer’s disease

(2014) Fatima Ali-Rahmani et al.   Frontiers in Pharmacology

Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS

(2014) Peter N. Alexandrov et al.   Frontiers in Neurology

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

(2014) Gary P Morris et al.   Acta Neuropathologica Communications

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

The relationship among mTOR, beta-amyloid and tau: Therapeutic implications for Alzheimer's disease

(2013) Salvatore Oddo   Alzheimers & Dementia

Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective

(2013) Verena Wieser et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Vascular Factors and Mitochondrial Dysfunction: a Central Role in the Pathogenesis of Alzheimer’s Disease

(2013) Daniele Orsucci et al.   CURRENT NEUROVASCULAR RESEARCH

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review

(2013) Maria Markaki et al.   GERONTOLOGY

Epigenetic signature and enhancer activity of the human APOE gene

(2013) Chang-En Yu et al.   HUMAN MOLECULAR GENETICS

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

(2013) Gerwyn Morris et al.   METABOLIC BRAIN DISEASE

Regulation of Neurotropic Signaling by the Inducible, NF-kB-Sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells

(2013) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

(2013) Liang Hong et al.   NEUROLOGICAL RESEARCH

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

(2013) Valentina Lulli et al.   PLoS One

Increased Levels of Antigen-Bound β-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer’s Disease Patients

(2013) Madalina Maftei et al.   PLoS One

Alzheimer’s Disease: Analyzing the Missing Heritability

(2013) Perry G. Ridge et al.   PLoS One

In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease

(2013) Julio Acosta-Cabronero et al.   PLoS One

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

Iron and hepcidin: a story of recycling and balance

(2013) C. Camaschella   Hematology-American Society of Hematology Education Program

Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

(2013) Gaël Chételat et al.   NeuroImage-Clinical

Lipopolysaccharide induces IFN-γ production in human NK cells

(2013) Leonid M. Kanevskiy et al.   Frontiers in Immunology

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

(2013) Tobias Jung et al.   Redox Biology

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

(2013) Sharon C Yates et al.   Acta Neuropathologica Communications

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease

(2012) Uwe Konietzko   Current Alzheimer Research

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   Current Alzheimer Research

Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1

(2012) Khizr I. Rathore et al.   GLIA

Sustained Submicromolar H2O2Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

(2012) Gunda Millonig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

(2012) James G. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease

(2012) Gunnar K. Gouras   JOURNAL OF NEUROCHEMISTRY

Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Neuroinflammatory phenotype in early Alzheimer's disease

(2012) Tiffany L. Sudduth et al.   NEUROBIOLOGY OF AGING

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Natural Killer Cells in Alzheimer’s Disease

(2012) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

T Cell Recruitment in the Brain during Normal Aging

(2012) Jickssa M. Gemechu et al.   Frontiers in Cellular Neuroscience

GSK3 as a Sensor Determining Cell Fate in the Brain

(2012) Adam R. Cole   Frontiers in Molecular Neuroscience

A pivotal role of GSK-3 in synaptic plasticity

(2012) Clarrisa A. Bradley et al.   Frontiers in Molecular Neuroscience

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells

(2011) T. Weichhart et al.   BLOOD

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

(2011) Cristian A. Lasagna-Reeves et al.   FEBS LETTERS

Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2′ mapping

(2011) Yuanyuan Qin et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Immune profiling of Alzheimer patients

(2011) Mariavaleria Pellicanò et al.   JOURNAL OF NEUROIMMUNOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Oxidative stress-mediated regulation of proteasome complexes

(2011) C. T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

(2011) C. Holmes et al.   NEUROLOGY

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

(2011) Anne Eckert et al.   Alzheimers Research & Therapy

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Combinatorial markers of MCI conversion: Cytokines and MRI measures together predict disease progression

(2010) Simon Lovestone et al.   Alzheimers & Dementia

Molecular interplay between mTOR, Aβ and tau: Effects on cognitive impairments

(2010) Salvatore Oddo   Alzheimers & Dementia

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunological Origin and Functional Properties of Catalytic Autoantibodies to Amyloid β Peptide

(2010) Sudhir Paul et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Implications of apolipoprotein E genotype on inflammation and vitamin E status

(2010) Patricia Huebbe et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide

(2010) Jeremy P. McAleer et al.   TRENDS IN IMMUNOLOGY

Selective neuronal vulnerability to oxidative stress in the brain

(2010) Wang   Frontiers in Aging Neuroscience

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative Stress and Insulin Resistance: The Coronary Artery Risk Development in Young Adults study

(2009) K. Park et al.   DIABETES CARE

Direct recognition of LPS by human but not murine CD8+T cellsviaTLR4 complex

(2009) Mousa Komai‐Koma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Lipopolysaccharide Potentiates Effector T Cell Accumulation into Nonlymphoid Tissues through TRIF

(2009) J. P. McAleer et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression

(2009) Ricardo Quiroz-Baez et al.   NEUROCHEMISTRY INTERNATIONAL

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Quantitative MR Phase-corrected Imaging to Investigate Increased Brain Iron Deposition of Patients with Alzheimer Disease

(2009) Wen-zhen Zhu et al.   RADIOLOGY

Oxidative Stress and Autophagy in the Regulation of Lysosome-Dependent Neuron Death

(2008) Violetta N. Pivtoraiko et al.   ANTIOXIDANTS & REDOX SIGNALING

Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

(2008) Hiroaki Taguchi et al.   AUTOIMMUNITY REVIEWS

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Plasma antibodies to Aβ40 and Aβ42 in patients with Alzheimer's disease and normal controls

(2008) Wuhua Xu et al.   BRAIN RESEARCH

Astroglia in dementia and Alzheimer's disease

(2008) J J Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk

(2008) Susana Minguet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

The modulatory effects of lipopolysaccharide-stimulated B cells on differential T-cell polarization

(2008) Hui Xu et al.   IMMUNOLOGY

Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

(2008) Long Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

(2008) Chengyong Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A potential pathogenetic role of iron in Alzheimer's disease

(2008) Laura Silvestri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

(2008) Marta Martinez-Vicente et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid peroxidation up-regulates BACE1 expressionin vivo: a possible early event of amyloidogenesis in Alzheimer’s disease

(2008) Liuji Chen et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras

(2008) Scot R. Kimball et al.   JOURNAL OF PINEAL RESEARCH

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE