Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Alternative Macrophage Activation Is Increased in Asthma

(2016) Pierre-Olivier Girodet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

(2016) Qi Wang et al.   CANCER CELL

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

Irgm1 is required for the inflammatory function of M1 macrophage in early experimental autoimmune encephalomyelitis

(2016) Yanwen Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Contribution of CD14 and TLR4 to changes of the PI(4,5)P2 level in LPS-stimulated cells

(2016) Agnieszka Płóciennikowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways

(2016) Julia Barbara Kral et al.   Scientific Reports

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

An alpha-adrenergic agonist protects hearts by inducing Akt1-mediated autophagy

(2015) Mikihiko Nakaoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tsc1 is a Critical Regulator of Macrophage Survival and Function

(2015) Chunmin Fang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oligosaccharide modification byN-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma

(2015) Arisa Kato et al.   EXPERIMENTAL DERMATOLOGY

Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis

(2015) Noemi Rotllan et al.   FASEB JOURNAL

AKT mediated glycolytic shift regulates autophagy in classically activated macrophages

(2015) Sumit Kumar Matta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages

(2015) Christina Doxaki et al.   JOURNAL OF IMMUNOLOGY

Annexin A2 Regulates Autophagy inPseudomonas aeruginosaInfection through the Akt1–mTOR–ULK1/2 Signaling Pathway

(2015) Rongpeng Li et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-kinase β, phosphoinositide 3-kinase δ, and phosphoinositide 3-kinase γ mediate the anti-inflammatory effects of magnesium sulfate

(2015) Ping-Ying Lee et al.   JOURNAL OF SURGICAL RESEARCH

Gαi1and Gαi3regulate macrophage polarization by forming a complex containing CD14 and Gab1

(2015) Xianjing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Akt isoforms in vascular disease

(2015) Haixiang Yu et al.   VASCULAR PHARMACOLOGY

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis

(2015) M Yang et al.   Cell Death & Disease

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy

(2015) Sachiko Ito et al.   Scientific Reports

Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer

(2015) Yanshuang Li et al.   Scientific Reports

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition

(2014) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

A unique role for p53 in the regulation of M2 macrophage polarization

(2014) L Li et al.   CELL DEATH AND DIFFERENTIATION

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages

(2014) J. P. Luyendyk et al.   JOURNAL OF IMMUNOLOGY

Cholesterol-Rich Membrane Rafts and Lyn Are Involved in Phagocytosis during Pseudomonas aeruginosa Infection

(2014) S. Kannan et al.   JOURNAL OF IMMUNOLOGY

Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis

(2014) Seung-jae Kim et al.   JOURNAL OF IMMUNOLOGY

Induction of Endotoxin Tolerance by Pathogenic Neisseria Is Correlated with the Inflammatory Potential of Lipooligosaccharides and Regulated by MicroRNA-146a

(2014) M. Liu et al.   JOURNAL OF IMMUNOLOGY

Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses

(2014) Emine Sahin et al.   JOURNAL OF IMMUNOLOGY

Chronic Lymphocytic Leukemia: A Paradigm of Innate Immune Cross-Tolerance

(2014) Teresa Jurado-Camino et al.   JOURNAL OF IMMUNOLOGY

Macrophage deficiency of Akt2 reduces atherosclerosis inLdlrnull mice

(2014) Vladimir R. Babaev et al.   JOURNAL OF LIPID RESEARCH

Anti-inflammation effects of naloxone involve phosphoinositide 3-kinase delta and gamma

(2014) Tao-Yeuan Wang et al.   JOURNAL OF SURGICAL RESEARCH

A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis

(2014) Shweta Joshi et al.   MOLECULAR CANCER RESEARCH

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

(2014) Lisa T. C. Vogelpoel et al.   Nature Communications

Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages

(2014) Katherine A. Owen et al.   PLoS Pathogens

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway

(2013) Gang Wan et al.   Autophagy

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

(2013) E. Zonari et al.   BLOOD

Sepsis-Induced Disseminated Intravascular Coagulation, Symmetrical Peripheral Gangrene, and Amputations

(2013) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

Rapamycin unbalances the polarization of human macrophages to M1

(2013) Alessia Mercalli et al.   IMMUNOLOGY

Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice

(2013) E. Vergadi et al.   JOURNAL OF IMMUNOLOGY

Dissociation of Endotoxin Tolerance and Differentiation of Alternatively Activated Macrophages

(2013) R. Rajaiah et al.   JOURNAL OF IMMUNOLOGY

Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling

(2013) V. Tsiperson et al.   JOURNAL OF IMMUNOLOGY

The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis

(2013) Z. Chen et al.   JOURNAL OF IMMUNOLOGY

Akt1-Mediated Regulation of Macrophage Polarization in a Murine Model of Staphylococcus aureus Pulmonary Infection

(2013) Feng Xu et al.   JOURNAL OF INFECTIOUS DISEASES

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

(2013) Jinli Wang et al.   PLoS Pathogens

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

(2012) He Huang et al.   Autophagy

Induction of IL-4R -dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

(2012) D. Ruckerl et al.   BLOOD

The biology of nematode- and IL4R -dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics

(2012) G. D. Thomas et al.   BLOOD

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K

(2012) Ty Dale Troutman et al.   CELL CYCLE

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

(2012) Liang Ding et al.   Cell Metabolism

Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice

(2012) Simon Clare et al.   INFECTION AND IMMUNITY

Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes

(2012) Joel W. Graff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Tuberous Sclerosis Complex 1 in Regulating Innate Immunity

(2012) H. Pan et al.   JOURNAL OF IMMUNOLOGY

Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2

(2012) Emilie Bourdonnay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Current trends in inflammatory and immunomodulatory mediators in sepsis

(2012) M. Aziz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology

Managing Macrophages in Rheumatoid Arthritis by Reform or Removal

(2012) Jun Li et al.   Current Rheumatology Reports

Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells

(2011) T. Weichhart et al.   BLOOD

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

Alternative activation of macrophages by IL-4 requires SHIP degradation

(2011) Shelley B. Weisser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

(2011) Marta López-Peláez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protective Role of Akt2 in Salmonella enterica Serovar Typhimurium-Induced Gastroenterocolitis

(2011) Winnie W. S. Kum et al.   INFECTION AND IMMUNITY

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid Cell IL-10 Production in Response to Leishmania Involves Inactivation of Glycogen Synthase Kinase-3  Downstream of Phosphatidylinositol-3 Kinase

(2011) D. Nandan et al.   JOURNAL OF IMMUNOLOGY

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

(2011) O. M. Pena et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10

(2011) A. Dominguez-Soto et al.   JOURNAL OF IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine

(2010) Cécilia Chassin et al.   Cell Host & Microbe

Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

(2010) Wai-Ping Fung-Leung   CELLULAR SIGNALLING

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

(2010) WuQiang Fan et al.   EMBO JOURNAL

Functional role of Akt in macrophage-mediated innate immunity

(2010) Yong Gyu Lee   Frontiers in Bioscience-Landmark

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF- B Activation in Macrophages

(2010) B. Chaurasia et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway

(2010) Hun-Jung Park et al.   MOLECULAR IMMUNOLOGY

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

(2009) M. D. Säemann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

Akt2 is required for macrophage chemotaxis

(2009) Baogang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

miR-146a Is Critical for Endotoxin-induced Tolerance

(2009) Md A. Nahid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression

(2009) Vassiliki Zacharioudaki et al.   JOURNAL OF IMMUNOLOGY

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Phosphoinositide 3-Kinases γ and δ, Linkers of Coordinate C5a Receptor-Fcγ Receptor Activation and Immune Complex-induced Inflammation

(2008) Stephanie Konrad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide

(2008) Alicia Arranz et al.   MOLECULAR IMMUNOLOGY

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark