Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer's Disease

(2017) Laura D. Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The influence of common free radicals and antioxidants on development of Alzheimer’s Disease

(2016) Karolina A. Wojtunik-Kulesza et al.   BIOMEDICINE & PHARMACOTHERAPY

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Caloric restriction and the precision-control of autophagy: A strategy for delaying neurodegenerative disease progression

(2016) C. Ntsapi et al.   EXPERIMENTAL GERONTOLOGY

Mitohormesis in exercise training

(2016) Troy L. Merry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study

(2016) Ruth Remington et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain

(2016) J. Sepulcre et al.   JOURNAL OF NEUROSCIENCE

Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease

(2016) Caroline Van Cauwenberghe et al.   MAMMALIAN GENOME

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

(2016) Joana S. Cristóvão et al.   Oxidative Medicine and Cellular Longevity

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Triad of Risk for Late Onset Alzheimer’s: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex

(2016) Yiwei Wang et al.   Frontiers in Aging Neuroscience

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

(2016) Yanfang Li et al.   Frontiers in Aging Neuroscience

Therapies for Prevention and Treatment of Alzheimer’s Disease

(2016) J. Mendiola-Precoma et al.   Biomed Research International

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

(2016) Mario Baumgart et al.   Cell Systems

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

(2015) Matthew Baumgart et al.   Alzheimers & Dementia

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

(2015) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

The structure and function of ‘active zone material’ at synapses

(2015) Joseph A. Szule et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

(2014) Michael A Castello et al.   BMC Neurology

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old

(2014) John L. Robinson et al.   BRAIN

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

(2014) Kris Simone Tranches Dias et al.   Current Neuropharmacology

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

(2014) Eric C. Miller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mild Cognitive Impairment and Asymptomatic Alzheimer Disease Subjects

(2014) Diego Iacono et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

(2014) Charles C. Caldwell et al.   Neurotherapeutics

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

(2013) Nicola Raule et al.   AGING CELL

Recent advances in the application of metabolomics to Alzheimer's Disease

(2013) Eugenia Trushina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathogenesis of Alzheimer Disease: Role of Oxidative Stress, Amyloid-β Peptides, Systemic Ammonia and Erythrocyte Energy Metabolism

(2013) Elena Kosenko et al.   CNS & Neurological Disorders-Drug Targets

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

(2013) N. Rajasekar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reversal of Metabolic Deficits by Lipoic Acid in a Triple Transgenic Mouse Model of Alzheimer's Disease: A 13C NMR Study

(2013) Harsh Sancheti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nucleic acid oxidation: an early feature of Alzheimer's disease

(2013) Melissa A. Bradley-Whitman et al.   JOURNAL OF NEUROCHEMISTRY

A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial

(2013) R. J. Kryscio et al.   Journal of Nutrition Health & Aging

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

(2013) P.K. Kamat et al.   NEUROSCIENCE

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

(2013) Siddhartha Mondragón-Rodríguez et al.   Oxidative Medicine and Cellular Longevity

Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

(2013) Roel Quintens et al.   PLoS One

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

The role of iron as a mediator of oxidative stress in Alzheimer disease

(2012) Rudy J. Castellani et al.   BIOFACTORS

Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

(2012) Cecile Vernochet et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

(2012) Shivika Rai et al.   JOURNAL OF NEUROIMMUNOLOGY

Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases

(2012) Kunikazu Tanji et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

Differences in the Cellular Uptake and Intracellular Itineraries of Amyloid Beta Proteins 40 and 42: Ramifications for the Alzheimer’s Drug Discovery

(2012) Rajesh S. Omtri et al.   MOLECULAR PHARMACEUTICS

The BCM theory of synapse modification at 30: interaction of theory with experiment

(2012) Leon N Cooper et al.   NATURE REVIEWS NEUROSCIENCE

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

(2012) Sönke Arlt et al.   NEUROCHEMICAL RESEARCH

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

(2011) Karen Schmitt et al.   ANTIOXIDANTS & REDOX SIGNALING

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: A phase IV clinical report

(2011) Payel Banerjee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease

(2010) Gary E. Gibson et al.   Annals of the New York Academy of Sciences

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

(2010) Norman J. Haughey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

(2010) Xianlin Han   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer’s disease cybrids

(2010) Isaac G. Onyango et al.   JOURNAL OF NEUROCHEMISTRY

A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia

(2010) A. Chan et al.   Journal of Nutrition Health & Aging

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Alzheimer's disease clinical trials: Methods and placebo outcomes

(2009) Lon S. Schneider et al.   Alzheimers & Dementia

Vitamin E, Vitamin C, Beta Carotene, and Cognitive Function Among Women With or at Risk of Cardiovascular Disease

(2009) Jae Hee Kang et al.   CIRCULATION

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

(2009) S.M. Cardoso et al.   EXPERIMENTAL NEUROLOGY

Mitochondria, cholesterol and amyloid β peptide: a dangerous trio in Alzheimer disease

(2009) Anna Colell et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

(2008) Alain Boom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

(2008) Anne Eckert et al.   Neurodegenerative Diseases

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE

Oxidatively modified RNA in mild cognitive impairment

(2007) Mark A. Lovell et al.   NEUROBIOLOGY OF DISEASE