Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

(2014) Eiron Cudaback et al.   BIOCHEMICAL PHARMACOLOGY

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2)

(2014) Brandon M. Jones et al.   Frontiers in Cellular Neuroscience

APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease

(2013) Yue Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

(2013) Agnieszka Paradowska-Gorycka et al.   HUMAN IMMUNOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Mercury, APOE, and children's neurodevelopment

(2013) Sharon Ng et al.   NEUROTOXICOLOGY

The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs for the Prevention of Alzheimers Disease

(2012) Greg M. Cole et al.   CNS & Neurological Disorders-Drug Targets

Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor

(2012) Xianwu Li et al.   FASEB JOURNAL

Antagonism of Neuronal Prostaglandin E2 Receptor Subtype 1 Mitigates Amyloid β Neurotoxicity In Vitro

(2012) Xianwu Li et al.   Journal of Neuroimmune Pharmacology

Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation

(2012) Eiron Cudaback et al.   Journal of Neuroinflammation

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

(2011) C Dirk Keene et al.   CURRENT OPINION IN NEUROBIOLOGY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Apolipoprotein E isoform-dependent microglia migration

(2011) Eiron Cudaback et al.   FASEB JOURNAL

Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation

(2011) Xianwu Li et al.   GLIA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION

Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints

(2007) Lisa Mosconi et al.   BIOLOGICAL PSYCHIATRY

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING