Microglial Priming and Alzheimer’s Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults

(2016) Nadine Külzow et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195

(2016) Masamichi Yokokura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

(2016) Sylvie L. Lesuis et al.   Oncotarget

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

(2016) Jian-hui Wang et al.   Oncotarget

DNA methylation of the IL-1β promoter and associated epigenetic regulators are modulated by immune activation, aging, and pharmacological demethylation in primary and BV-2 murine microglia

(2015) S.M. Matt et al.   BRAIN BEHAVIOR AND IMMUNITY

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

(2015) W.A. Banks   BRAIN BEHAVIOR AND IMMUNITY

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Infection, systemic inflammation, and Alzheimer's disease

(2015) Siok Lam Lim et al.   MICROBES AND INFECTION

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Delirium from the gliocentric perspective

(2015) Adonis Sfera et al.   Frontiers in Cellular Neuroscience

Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation

(2015) Mingju Cao et al.   Frontiers in Cellular Neuroscience

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

(2014) Anne-Laure Dinel et al.   Journal of Neuroinflammation

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Alzheimer's disease and epigenetic diet

(2014) Zeynep Sezgin et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Centrally Administered Etanercept on Behavior, Microglia and Astrocytes in Mice Following a Peripheral Immune Challenge

(2014) Marie lou Camara et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation and the developing brain: Consequences for hippocampal neurogenesis and behavior

(2014) Holly F. Green et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of dietary supplementation of dates in Alzheimer's disease APPsw/2576 transgenic mice on oxidative stress and antioxidant status

(2014) Selvaraju Subash et al.   NUTRITIONAL NEUROSCIENCE

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

(2014) Matthew D Li et al.   Acta Neuropathologica Communications

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Bidirectional Relationship between Cognitive Function and Pneumonia

(2013) Faraaz Ali Shah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants

(2013) T. Michael O’Shea et al.   BRAIN BEHAVIOR AND IMMUNITY

Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children - developmental psychoneuroimmunology

(2013) Thomas G. O'Connor et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia

(2013) Vishnu Kannan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inflammation and the two-hit hypothesis of schizophrenia

(2013) Keith A. Feigenson et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Epigenetics and the Modulation of Neuroinflammation

(2013) Gwenn A. Garden   Neurotherapeutics

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Autism spectrum disorder in children born preterm—role of exposure to perinatal inflammation

(2013) Suzanne J. Meldrum et al.   Frontiers in Neuroscience

Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

(2012) Masashi Kitazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism

(2012) Alan S. Brown   Developmental Neurobiology

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

(2012) Ursula Püntener et al.   Journal of Neuroinflammation

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

(2012) Karim Belarbi et al.   Journal of Neuroinflammation

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

(2011) Michael Sy et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults

(2011) Henrik Hagberg et al.   ANNALS OF NEUROLOGY

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning

(2011) Michael D. Burton et al.   BRAIN BEHAVIOR AND IMMUNITY

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Sex differences in microglial colonization of the developing rat brain

(2011) Jaclyn M. Schwarz et al.   JOURNAL OF NEUROCHEMISTRY

Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration

(2011) Sarah B. Matousek et al.   Journal of Neuroimmune Pharmacology

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

Early-Life Experience Decreases Drug-Induced Reinstatement of Morphine CPP in Adulthood via Microglial-Specific Epigenetic Programming of Anti-Inflammatory IL-10 Expression

(2011) J. M. Schwarz et al.   JOURNAL OF NEUROSCIENCE

HIgh dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the rancho bernardo study

(2011) L. B. Lopez et al.   Journal of Nutrition Health & Aging

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Viral infection and neural stem/progenitor cell's fate: Implications in brain development and neurological disorders

(2011) Sulagna Das et al.   NEUROCHEMISTRY INTERNATIONAL

Epigenetic mechanisms elicited by nutrition in early life

(2011) Roberto Berni Canani et al.   NUTRITION RESEARCH REVIEWS

Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels

(2011) Catherine Féart et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Altered inflammatory responses in preterm children with cerebral palsy

(2010) Chang-Yi Lin et al.   ANNALS OF NEUROLOGY

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

(2010) Angela M. Wynne et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

The “LEARn” (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer’s disease, and proposes remedial steps

(2010) Debomoy K. Lahiri et al.   EXPERIMENTAL GERONTOLOGY

Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

(2010) Matthew G. Frank et al.   JOURNAL OF NEUROIMMUNOLOGY

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

(2010) Saebyeol Jang et al.   JOURNAL OF NUTRITION

Systemic infection and delirium: when cytokines and acetylcholine collide

(2010) Willem A van Gool et al.   LANCET

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

(2010) Carol Murray et al.   NEUROBIOLOGY OF AGING

Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline

(2010) Staci D. Bilbo   NEUROBIOLOGY OF LEARNING AND MEMORY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Role of Infection in the Pathogenesis of Alzheimerʼs Disease

(2009) Clive Holmes et al.   CNS DRUGS

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior

(2009) James A. Joseph et al.   JOURNAL OF NUTRITION

The “window of susceptibility” for inflammation in the immature central nervous system is characterized by a leaky blood–brain barrier and the local expression of inflammatory chemokines

(2009) Lucia Schoderboeck et al.   NEUROBIOLOGY OF DISEASE

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?

(2009) Noga Ron-Harel et al.   TRENDS IN NEUROSCIENCES

Early-life programming of later-life brain and behavior: a critical role for the immune system

(2009) Staci D. Bilbo   Frontiers in Behavioral Neuroscience

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

(2008) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-Term Cognitive Outcome of Delirium in Elderly Hip Surgery Patients

(2008) Martin G. Kat et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

In utero supplementation with methyl donors enhances allergic airway disease in mice

(2008) John W. Hollingsworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

(2008) Ryan N. Dilger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?

(2008) Diane B. Miller et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress

(2008) Nathan L. Sparkman et al.   NEUROIMMUNOMODULATION

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

Cytokines and Myelination in the Central Nervous System

(2008) Thomas Schmitz et al.   TheScientificWorldJOURNAL

Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood

(2007) Staci D. Bilbo et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: A prospective study

(2007) Romola S. Bucks et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

(2007) Jing Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

(2007) Y. Huang et al.   NEUROBIOLOGY OF AGING

Spatial reference and working memory across the lifespan of male Fischer 344 rats

(2007) J.L. Bizon et al.   NEUROBIOLOGY OF AGING