Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

(2017) Gary E. Gibson et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

(2017) Pinar E. Coskun et al.   JOURNAL OF ALZHEIMERS DISEASE

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

(2016) Neta Gazit et al.   NEURON

Alterations in Mitochondrial Quality Control in Alzheimer’s Disease

(2016) Qian Cai et al.   Frontiers in Cellular Neuroscience

Mitochondrial division and fusion in metabolism

(2015) Madhuparna Roy et al.   CURRENT OPINION IN CELL BIOLOGY

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

(2015) Xuan Ye et al.   HUMAN MOLECULAR GENETICS

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

Mitochondrial import and degradation of amyloid-β peptide

(2014) Catarina Moreira Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

(2014) Nicol Birsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

Embryonic Stem Cell–Based Modeling of Tau Pathology in Human Neurons

(2013) Jerome Mertens et al.   AMERICAN JOURNAL OF PATHOLOGY

March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease

(2013) Anne Eckert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthetic Aβ oligomers (Aβ1–42 globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers

(2013) David Hermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease

(2013) Elliott J. Mufson et al.   Neurodegenerative Diseases

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit

(2012) Anh H. Pham et al.   HUMAN MOLECULAR GENETICS

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

(2012) Seungmin Lee et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Mitochondria as a central sensor for axonal degenerative stimuli

(2012) Felipe A. Court et al.   TRENDS IN NEUROSCIENCES

Caspase-3 in the central nervous system: beyond apoptosis

(2012) Marcello D’Amelio et al.   TRENDS IN NEUROSCIENCES

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

(2012) Kanae Iijima-Ando et al.   PLoS Genetics

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease

(2011) Laurel Vana et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Trafficking Kinesin Protein (TRAK)-mediated Transport of Mitochondria in Axons of Hippocampal Neurons

(2011) Kieran Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

(2011) N. M. Kanaan et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier

(2011) N. Ohno et al.   JOURNAL OF NEUROSCIENCE

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

(2011) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks

(2010) Olga S. Koutsopoulos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Neuroprotective strategies involving ROS in Alzheimer disease

(2010) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of  -Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

(2010) X.-L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

(2010) Xinglong Wang et al.   Neurodegenerative Diseases

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION

Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex

(2009) Xingguo Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation

(2009) Alicia M. Pickrell et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons

(2009) Y.-M. Chen et al.   JOURNAL OF NEUROSCIENCE

KIF5B Motor Adaptor Syntabulin Maintains Synaptic Transmission in Sympathetic Neurons

(2009) H. Ma et al.   JOURNAL OF NEUROSCIENCE

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

(2008) Andrew F. MacAskill et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES

The Function of Mitochondria in Presynaptic Development at the Neuromuscular Junction

(2007) Chi Wai Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability

(2007) Maya Dubey et al.   CELL MOTILITY AND THE CYTOSKELETON