Proteolytic processing of Alzheimer’s β-amyloid precursor protein

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

(2011) Manuel T Gersbacher et al.   Molecular Neurodegeneration

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

(2011) Kengo Uemura et al.   Molecular Neurodegeneration

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease

(2010) Annica Sjölander et al.   Molecular Neurodegeneration

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

(2010) Brian D. Hitt et al.   Molecular Neurodegeneration

Substrate check of γ-secretase

(2010) Yun-wu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

(2010) Luca Giliberto et al.   PLoS One

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production

(2009) F C Lourenço et al.   CELL DEATH AND DIFFERENTIATION

Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1

(2009) Yun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration

(2009) K. Tabuchi et al.   JOURNAL OF NEUROSCIENCE

Statin's Excitoprotection Is Mediated by sAPP and the Subsequent Attenuation of Calpain-Induced Truncation Events, Likely via Rho-ROCK Signaling

(2009) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

(2009) Shuji Matsuda et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional β-secretase candidate(s)

(2008) Israel Schechter et al.   BIOLOGICAL CHEMISTRY

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

(2008) Luca Giliberto et al.   Molecular Neurodegeneration

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE