Review
Medicine, General & Internal
Lin Jiang, Jingbo Zhang, Yan Xu, Heng Xu, Mengzhao Wang
Summary: The phosphosphatidylinositol-3-kinase (PI3K) signaling pathway plays a crucial role in the development of lung cancer. Traditional treatment methods have limited efficacy, but molecular targeted therapy has improved survival and prognosis for patients. There is a growing body of research focusing on NSCLC and the PI3K signaling pathway.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tsung-Ming Chang, Yao-Chang Chiang, Chiang-Wen Lee, Chieh-Mo Lin, Mei-Ling Fang, Miao-Ching Chi, Ju-Fang Liu, Yu Ru Kou
Summary: This study reveals the function of CXCL14 in promoting EMT and metastasis in lung cancer, with ACKR2 playing a role in this process. These findings can be used as prognostic biomarkers of lung cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yaomei He, Xiulin Jiang, Lincan Duan, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang, Yongbin Chen
Summary: In this study, a human-specific long non-coding RNA (lncRNA, ENST00000595422) named PKMYT1AR was identified as induced in NSCLC, especially in cancerous cell lines, and its high expression correlated with worse clinical outcomes. Knockdown of PKMYT1AR inhibited tumor cell proliferation, migration, and formation abilities. PKMYT1AR was shown to directly interact with miR-485-5p to attenuate its inhibitory role on the downstream oncogenic factor PKMYT1 in NSCLC. Furthermore, the miR-485-5p was downregulated in both cancerous cell lines and serum from NSCLC patients, and its forced expression inhibited tumor cell proliferation and migration abilities.
Article
Oncology
Xueru Zhu, Yiting Wang, Chang Jiang, Xiaoyang Li, Linying Sun, Guangzhong Wang, Xiaolong Fu
Summary: This study explored the intrinsic radiosensitivity of non-small cell lung cancer (NSCLC) and identified radiosensitivity-specific proteins that can guide individualized radiation therapy. The study also validated the functions of these proteins in NSCLC cell lines and delineated the atlas network of NSCLC radiosensitivity-related signaling pathways, which could further contribute to the understanding of the underlying mechanism.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Manman Liang, Lijing Wang, Zhengui Sun, Xingwu Chen, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Summary: This study reveals that TRIM15 is frequently upregulated in NSCLC and associated with poor prognosis. Functionally, TRIM15 promotes proliferation and metastasis of NSCLC cells through its E3 ubiquitin ligase activity. Mechanistically, TRIM15 directly targets Keap1 and promotes its ubiquitination and degradation, resulting in the escape of Nrf2 from Keap1-mediated degradation, subsequently promoting antioxidant response and tumor progression.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Tao Lu, Ming Li, Mengnan Zhao, Yiwei Huang, Guoshu Bi, Jiaqi Liang, Zhencong Chen, Yuansheng Zheng, Junjie Xi, Zongwu Lin, Cheng Zhan, Wei Jiang, Qun Wang, Lijie Tan
Summary: Metformin has been shown to inhibit the proliferation of non-small cell lung cancer cells through the AMPK-CEBPB-PDL1 signaling pathway, with potential for suppressing tumor growth demonstrated in animal experiments.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Sutthaorn Pothongsrisit, Kuntarat Arunrungvichian, Yoshihiro Hayakawa, Boonchoo Sritularak, Supachoke Mangmool, Varisa Pongrakhananon
Summary: Erianthridin (ETD) inhibits cell migration and invasion by disrupting actin stress fibers and lamellipodia formation, downregulating MMP-2 and MMP-9 expression. It also attenuates Akt/mTOR/p70(S6K) signaling pathway, leading to suppression of lung cancer metastasis. These findings suggest ETD as a promising antimetastatic agent against non-small-cell lung cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fujuan Liu, Tao Liu, Haiying Li
Summary: The study found that aloperine (ALO) has anti-tumor effects on non-small cell lung cancer cells, inhibiting proliferation, migration, invasion, and inducing apoptosis. ALO affects cell progression by modulating the PI3K/Akt signaling pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Plant Sciences
Lehe Yang, Wenjing Zhu, Yulei Yao, Mengyao Xie, Shuoshuo Lv, Jiayun Cheng, Gexiang Cai, Haiyang Zhao, Chengguang Zhao, Liangxing Wang, Xiaoying Huang
Summary: Hypocrellin A (HA) has shown antitumor effects on NSCLC by negatively impacting cell viability, migration, invasion, and promoting apoptosis. HA binds to FGFR1 and inhibits its autophosphorylation and downstream signaling. In a mouse tumor model, HA demonstrated inhibition of tumor growth with no observed toxic effects, suggesting it as a potential new FGFR1-targeted treatment for NSCLC.
Article
Pharmacology & Pharmacy
Yixin Chen, Mei-Juan Tu, Fangwei Han, Zhenzhen Liu, Neelu Batra, Primo N. Lara, Hong -Wu Chen, Huichang Bi, Ai -Ming Yu
Summary: The research found that miR-22-3p, miR-9-5p, and miR-218-5p are antiproliferative miRNAs targeting non-small cell lung cancer (NSCLC) cells, and they inhibit folate metabolism and alter amino acid metabolism in NSCLC cells. In addition, the inhibition of glucose uptake by miR-22-3p and the reduction of serine biosynthesis from glucose by miR-9-5p and -218-5p were also confirmed. Recombinant miR-22-3p was more effective than miR-9-5p and -218-5p in inhibiting NSCLC cell respiration, glycolysis, and colony formation, without causing any toxicity.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cell Biology
Anqi Wang, Wen Yang, Yue Li, Yang Zhang, Jieqi Zhou, Ruochen Zhang, Weijie Zhang, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu, Jian-an Huang
Summary: This study reveals that CPNE1 promotes tumorigenesis in NSCLC by interacting with RACK1 and activating the MET signaling pathway. The combination of a MET inhibitor with an EGFR-TKI is more effective in inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Pharmacology & Pharmacy
A. S. Pal, M. Bains, A. Agredo, A. L. Kasinski
Summary: Lung cancer is a major cause of cancer-related deaths, and overcoming resistance to EGFR inhibitors is crucial in the treatment of non-small cell lung cancer. This study identifies the important role of microRNAs in driving resistance to EGFR inhibitors in non-small cell lung cancer cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Si-yu Zhang, You-yi Lu, Xin-liang He, Yuan Su, Fen Hu, Xiao-shan Wei, Min-jie Pan, Qiong Zhou, Wei-bing Yang
Summary: This study demonstrates the potential of lutein as an antitumorigenic agent in non-small cell lung cancer. It inhibits cell proliferation, induces cell cycle arrest and apoptosis, and activates the ATR/Chk1/p53 signaling pathway through DNA damage. Lutein also impedes tumor growth and prolongs survival in mice.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Summary: Immune cells play a role in protecting against tumor progression, while aberrant expression of PD-L1 in cancer cells leads to tumor immune escape. This study found that ING4 induces the autophagic degradation of PD-L1, inhibiting immune escape in NSCLC. However, high expression of CK2 was found to correlate with low ING4 protein levels in NSCLC. Further analysis revealed that CK2 induces the phosphorylation of ING4-S150, leading to its degradation by JFK ubiquitin ligase. In contrast, CK2 gene knockout increased ING4 protein stability and T cell activity, inhibiting NSCLC immune escape. Additionally, the combination of a CK2 inhibitor and PD-1 antibody effectively enhanced antitumor immunotherapy.
Article
Chemistry, Multidisciplinary
Bohang Wu, Reece W. W. Lewis, Guotai Li, Yifan Gao, Bowen Fan, Benjamin Klemm, Jianan Huang, Junyou Wang, Martien A. A. Cohen Stuart, Rienk Eelkema
Summary: By constructing a coacervate hydrogel with a Michael addition-based chemical reaction network (CRN) as a platform, the state of the coacervate materials can be easily controlled by specific chemical signals. The designed pyridine-based ABA triblock copolymer can undergo regulation through quaternization by an allyl acetate electrophile and an amine nucleophile, resulting in gel construction and collapse in the presence of polyanions. The coacervate gels exhibit highly tunable stiffness and gelation times, as well as excellent self-healing ability and injectability with different sized needles, and accelerated degradation induced by chemical signal-induced coacervation disruption. This work represents a first step towards the development of a new class of signal-responsive injectable materials.
Review
Food Science & Technology
Meng-ge Tang, Sheng Zhang, Li-gui Xiong, Jing-hui Zhou, Jian-an Huang, Ai-qing Zhao, Zhong-hua Liu, Ai-ling Liu
Summary: Polyphenol oxidase (PPO) is a metalloenzyme in tea plants that plays a crucial role in enhancing defensive responses, cultivating high-quality germplasm resources, and producing functional tea products. The oxidative polymerization of PPO in tea manufacturing can provide functional foods for preventing and treating chronic non-communicable diseases. However, more comprehensive research is needed to understand the relationship between PPO and tea. This article provides a comprehensive review of the classification, catalytic mechanism, and utilization of PPO in modulating tea flavors, compositions, and nutrition, as well as the techniques for modifying and applying PPO based on modern enzymology and synthetic biology.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Infectious Diseases
Lirong Gao, Tingting Yang, Xiaohui Zhang, Wei Lei, Jian-an Huang
Summary: We retrospectively analyzed 3 cases of pulmonary nocardiosis using metagenomic next generation sequencing (mNGS) at the First Affiliated Hospital of Soochow University from January 2019 to April 2022. All patients had underlying diseases and were immunocompromised. Common symptoms included fever, cough, and expectoration. mNGS detected Nocardia spp. in bronchoalveolar lavage fluid (BALF) or blood samples. Patients were successfully treated with trimethoprim-sulfamethoxazole (TMP-SMX) and remained disease-free during follow-up.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Green & Sustainable Science & Technology
Xin Li, Texun Li, Li Liu, Zhen Wang, Xinyu Li, Jianan Huang, Jingqi Huang, Pangfeng Guo, Wei Xiong
Summary: To address the reduction of renewable energy caused by curtailment and the environmental pollution from isolated combined heat and power (CHP), this study extends the integrated energy system (IES) of hybrid concentrated solar power and combined heat and power (CSP-CHP) with power to gas (P2G) and carbon capture and storage (CCS) technologies. The proposed IES is optimized using a low carbon economic dispatch model for better wind power absorption and CO2 emission reduction. Simulation results demonstrate the superior performance of the proposed IES in terms of absorbing wind power and reducing CO2 emissions, achieving a 72.4% emission reduction compared to the base case.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Food Science & Technology
Changwei Liu, Haiyan Lin, Kuofei Wang, Zhixu Zhang, Jianan Huang, Zhonghua Liu
Summary: This study investigated the role of tea endophytes in black tea fermentation and their impact on black tea quality. The researchers collected fresh leaves and processed them into black tea, analyzing the biochemical composition and microbial community structure using high-throughput techniques. The results showed that certain bacteria and fungi dominated the fermentation process, and there were significant increases in enzymes and compounds related to fermentation. The study provides new insights into the changes in microbial communities during black tea fermentation and their impact on the quality of the final product.
Article
Hematology
Yang Wang, Wei-wei Ning, Yi-fan Jin, Qing-qing Zhu, Zai-liang Wang, Nan Su, Yan-bin Chen, Jian-an Huang, Cheng Chen
Summary: A patient with gastric carcinoma and PTTM showed significant improvement in PH and respiratory dysfunction after treatment with anlotinib.
THROMBOSIS JOURNAL
(2023)
Article
Chemistry, Applied
Chao Wang, Wazhen Xu, Yuqi Yuan, Yuke Zhai, Tengfei Hu, Jianan Huang, Zhonghua Liu, Qin Li
Summary: The study investigated the odor-active compounds in Fu-brick tea and their release behaviors during boiling-water. A total of 51 odor-active compounds were identified, and their release behaviors were analyzed using sensory, instrumental, and curve fitting analysis. The release rates of the compounds showed little correlation with their concentrations, molecular weights, and boiling points. Most odor-active compounds required evaporation of more than 24% of the added water during the boiling-water extraction process. Aroma recombination experiments were performed to identify the major contributors to the aroma profile of each condensed water based on odor activity value (OAV) calculation.
Article
Agricultural Engineering
Chenyu Shao, Jianjiao Chen, Zhidong Lv, Xizhi Gao, Shuning Guo, Rong Xu, Zhiying Deng, Suhang Yao, Zhida Chen, Yankai Kang, Jianan Huang, Zhonghua Liu, Chengwen Shen
Summary: This year, extreme drought in China has caused a 30% reduction in the yield of tea plantations. Tea plants have the potential to resist drought through high levels of polyphenols and theanine. By regulating metabolite levels, tea plants can reduce the levels of toxic oxygen radicals under drought conditions.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Ying Cai, Jin Zhou, Jianan Huang, Wenjuan Zhou, Yuting Wan, Martien A. Cohen Stuart, Junyou Wang
Summary: In this study, a novel bis-ligand (L2) with bipyridine groups connected by a tetra-ethylene oxide (4EO) spacer was used to form coordination complexes with copper ions in phosphate buffer, which could then bind polyacrylic acid (PAA) to produce catalytically active polymeric nanoparticles with well-defined structure and size, referred to as 'nanozymes'. By controlling the L2/Cu mixing ratio and using phosphate as a co-binding motif, cooperative copper centers with promoted oxidation activity were realized. These designed nanozymes demonstrated stable structure and activity even at higher temperatures and multiple application cycles. Increasing ionic strength enhanced their activity, similar to natural tyrosinase. This rational design approach resulted in nanozymes with optimized structure and active sites that outperformed natural enzymes, suggesting the potential application of this class of catalysts.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mingzhi Zhu, Jian Ouyang, Fang Zhou, Chenjie Zhao, Wan Zhu, Chunfang Liu, Peifang Huang, Jiafeng Li, Junwei Tang, Zhang Zhang, Jianan Huang, Miaomiao Wu, Kunbo Wang, Zhonghua Liu
Summary: This study found that Fu brick tea polysaccharides (FBTPSs) can inhibit obesity, hyperlipidemia, and inflammation, improve intestinal barrier function, and alleviate gut microbiota dysbiosis in high-fat diet-fed rats. FBTPSs regulated the production of gut microbiota-related metabolites and influenced the short-chain fatty acid-GPR signaling pathway, showing their potential as prebiotic agents for the treatment of obesity and dysbiosis of gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Correction
Oncology
Yulong Fu, Anqi Wang, Jieqi Zhou, Wei Feng, Minhua Shi, Xiao Xu, Hongqing Zhao, Liming Cai, Jian Feng, Xuedong Lv, Xiaodong Zhang, Wenjing Xu, Zhengrong Zhang, Guoer Ma, Jian Wang, Tong Zhou, Dahai Zhao, Haohui Fang, Zeyi Liu, Jian-an Huang
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Changwei Liu, Jinghui Zhou, Jianan Huang, Wei Xu, Zhonghua Liu
Summary: Polyphenol oxidase and its isoenzymes in the tea tree were studied for their expression and activity towards tea polyphenol substrates. Different methods, including protein sequence treatment and immobilization, were used to enhance the activity of the recombinant enzyme. Results showed that CsPPO1, CsPPO2, CsPPO3, and CsPPO4 were expressed as inclusion bodies and exhibited improved activity. Immobilization treatment significantly increased the efficiency of the CsPPO2 enzyme.
FERMENTATION-BASEL
(2023)
Article
Engineering, Environmental
Zhigao Sun, Xingchun Yang, Yuan Wu, Han Xie, Xiaoyu Lu, Jianan Huang, Dongliang Zhang, Mitang Wang
Summary: The focus of this work was on the process conditions and mechanism of phase separation activation treatment of an industrial byproduct called high-magnesium nickel slag (HMNS), as well as its potential as a precursor for a sustainable cement called magnesium phosphate cement (MPC). The study found that the phase separation structure in the HMNS played a crucial role in enhancing its pozzolanic activity, which is important for cement production. By optimizing the process conditions, the researchers were able to increase the dissolution of key elements in the HMNS and achieve a compressive strength comparable to ordinary Portland cement, while significantly reducing CO2 emissions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Feng-Xia Liang, Shi-Fu Li, Jie Yu, Liang-Liang Zhou, Jiang Wang, Can Fu, Xiang An, Jian-An Huang, Li Wang, Lin-Bao Luo
Summary: A series of MAPbBr(3-n)X(n) (X=Cl, I) single-crystal films with controllable thickness have been grown through space-limited inverse temperature crystallization, achieving filter-free narrowband photodetectors with peak responses at 505, 590 and 620 nm, corresponding to the green, yellow and red of traffic lights. These narrowband photodetectors demonstrate superior performance, with a maximum responsivity of 182 mA W^-1 and specific detectivity of 9.68 x 10(10) Jones, and a traffic light recognition assembly based on them shows good color recognition capability.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Biochemistry & Molecular Biology
Wen-wen Fang, Kuo-fei Wang, Fang Zhou, Jie Ou-yang, Zi-ying Zhang, Chang-wei Liu, Hong-zhe Zeng, Jian-an Huang, Zhong-hua Liu
Summary: This study compared the anti-obesity effects of oolong tea from different years on mice fed a high-fat diet. The results showed that oolong teas from 2001, 2011, and 2020 significantly decreased body weight and attenuated obesity in the mice. The teas from 2001 and 2011 achieved this mainly through regulating lipid metabolism and activating the AMPK/SREBP-1 pathway, while the teas from 2011 and 2020 modulated gut microbiota and promoted the growth of beneficial bacteria.
