The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

T cells and Parkinson's disease

(2017) R Lee Mosley et al.   LANCET NEUROLOGY

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson’s disease patients

(2017) Siyuan Chen et al.   NEUROSCIENCE LETTERS

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

(2017) Anna Mietelska-Porowska et al.   Journal of Immunology Research

Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes

(2017) Steven Pierce et al.   PLoS One

Parkinson's disease: Autoimmunity and neuroinflammation

(2016) Armando De Virgilio et al.   AUTOIMMUNITY REVIEWS

Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model

(2016) Annika Sommer et al.   Journal of Neuroinflammation

Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson’s Disease

(2016) Zhan Liu et al.   MOLECULAR NEUROBIOLOGY

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

(2016) Sarah A. Gagliano et al.   Annals of Clinical and Translational Neurology

Multiple Sclerosis and T Lymphocytes: An Entangled Story

(2015) Laurine Legroux et al.   Journal of Neuroimmune Pharmacology

Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study

(2014) Shu-yang Yu et al.   BMC Neurology

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

(2014) Hugo González et al.   Journal of Neuroinflammation

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

CD4+CD25+/highCD127low/- regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood

(2014) Babak Moradi et al.   ARTHRITIS RESEARCH & THERAPY

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

Repulsive Guidance Molecule-a Is Involved in Th17-Cell-Induced Neurodegeneration in Autoimmune Encephalomyelitis

(2014) Shogo Tanabe et al.   Cell Reports

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Parkinson's disease plasma biomarkers: An automated literature analysis followed by experimental validation

(2013) Tiziana Alberio et al.   Journal of Proteomics

Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population

(2013) Kun Nie et al.   NEUROSCIENCE LETTERS

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Reduced T helper and B lymphocytes in Parkinson's disease

(2012) Claire H. Stevens et al.   JOURNAL OF NEUROIMMUNOLOGY

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

(2012) Ravid Shechter et al.   JOURNAL OF PATHOLOGY

Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: Effects on regulatory T cells

(2012) Julie Rowin et al.   MUSCLE & NERVE

Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease

(2012) Tiziana Alberio et al.   Scientific Reports

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's disease

(2011) Fumitoshi Niwa et al.   Geriatrics & Gerontology International

Immune profiling of Alzheimer patients

(2011) Mariavaleria Pellicanò et al.   JOURNAL OF NEUROIMMUNOLOGY

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

(2011) Kiran Yanamandra et al.   PLoS One

Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood

(2010) U. Fiszer et al.   ACTA NEUROLOGICA SCANDINAVICA

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Multivariate analysis of differential lymphocyte cell cycle activity in Alzheimer's disease

(2010) Jens Stieler et al.   NEUROBIOLOGY OF AGING

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Anti-melanin antibodies are increased in sera in Parkinson's disease

(2009) K.L. Double et al.   EXPERIMENTAL NEUROLOGY

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Role of the innate immune system in the pathogenesis of multiple sclerosis

(2009) Roopali Gandhi et al.   JOURNAL OF NEUROIMMUNOLOGY

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells

(2009) W. Elyaman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of Parkinsonism

(2008) Adriana Galvan et al.   CLINICAL NEUROPHYSIOLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY