Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Maximilian Leitner, Sebastian Heck, Kenny Nguyen, Phu Quyen Nguyen, Shaza Harfoush, Eva Rosenkranz, Robert Bals, Quoc Thai Dinh
Summary: This study aimed to investigate the distribution and expression of IL-23R in allergic airway inflammation. The results showed that IL-23R is mainly found in macrophages and dendritic cells. HDM treatment leads to a significant increase of IL-23R-positive macrophages. IL-23R and IL-17 co-localize only in macrophages in lung tissue.
CELL AND TISSUE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carla M. P. Ribeiro, Matthew G. Higgs, Marianne S. Muhlebach, Matthew C. Wolfgang, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini
Summary: Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have provided a significant therapeutic advantage for people with cystic fibrosis (pwCF). However, these modulators face limitations in reducing chronic lung bacterial infection and inflammation, which are the main causes of respiratory damage and insufficiency in pwCF, especially in adults. This article revisits the debated issues of pulmonary bacterial infection and inflammatory processes in pwCF, highlighting the mechanisms favoring bacterial infection, the interplay between Pseudomonas aeruginosa and Staphylococcus aureus, and the cross-talk among bacteria, bronchial epithelial cells, and host immune defenses. The recent findings on the effect of CFTR modulators on bacterial infection and inflammation are also presented to identify potential therapeutic targets for respiratory pathology in pwCF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Article
Immunology
Jyoti Balhara, Latifa Koussih, Ashfaque Mohammed, Lianyu Shan, Bouchaib Lamkhioued, Abdelilah S. Gounni
Summary: This study revealed that deficiency of PTX3 results in an increase in lung CD11c(+)CD11b(+) DC numbers and function, exacerbating airway inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Louise Rethacker, Maxime Boy, Valeria Bisio, France Roussin, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Christine Sedlik, Eliane Piaggio, Antoine Toubert, Nicolas Dulphy, Anne Caignard
Summary: Innate lymphoid cells (ILCs), including NK cells and ILC3, play important roles in tissue immune homeostasis and tumor surveillance. In human lymph nodes, NK cells and ILC3s are the prominent subpopulations. However, in tumor-draining lymph nodes and breast cancer tumors, NK cells are more abundant while proportions of ILC3 subsets are low. The local tumor microenvironment inhibits NK cell functions through downregulation of a specific receptor, but cytokine stimulation can restore their functionality.
Article
Immunology
Aiko Ono-Ohmachi, Satoki Yamada, Satoru Uno, Masato Tamai, Kohei Soga, Shotaro Nakamura, Nobuyuki Udagawa, Yuko Nakamichi, Masanori Koide, Yoshikazu Morita, Tomohiro Takano, Takumi Itoh, Shigeru Kakuta, Chikao Morimoto, Shuji Matsuoka, Yoichiro Iwakura, Michio Tomura, Hiroshi Kiyono, Satoshi Hachimura, Haruyo Nakajima-Adachi
Summary: This study highlights the specific inflammatory relationship between MLNs and bone in food-allergic enteropathy, mediated by Th2-dominant-OVA-specific T cells and IL-4 production. Inhibition of IL-4 can reduce bone loss in EW-fed mice.
MUCOSAL IMMUNOLOGY
(2021)
Review
Immunology
Jing Zhang, Yuan Zou, Longmin Chen, Qianqian Xu, Yi Wang, Min Xie, Xiansheng Liu, Jianping Zhao, Cong-Yi Wang
Summary: Asthma is a multifactorial disorder characterized by chronic inflammation, hyper-responsiveness, remodeling, and reversible obstruction. Recent studies suggest that most cases are Th2-high type and regulatory T cells (Tregs) play an essential role in limiting the development of allergic diseases. Researchers are exploring new treatment methods based on Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Dong Wang, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari
Summary: The study revealed that loading baicalein in chitosan nanoparticles could serve as an anti-asthma treatment, helping to reduce inflammation and control asthma symptoms. These nanoparticles effectively impacted the immune response and airway sensitivity in asthma mice.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Diana C. Yanez, Ching-In Lau, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Anna Furmanski, Tessa Crompton
Summary: Foxa2 plays a significant role in lung function regulation and tissue homeostasis. Its absence in the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Foxa2 expression in T-cells is required to protect against Th2 inflammatory response and maintain the balance of effector cell differentiation and function in the lung.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zenghui Wang, Heming Xia, Binlong Chen, Yaoqi Wang, Qingqing Yin, Yue Yan, Ye Yang, Mingmei Tang, Jianxiong Liu, Ruiyang Zhao, Wenzhe Li, Qiang Zhang, Yiguang Wang
Summary: A novel type of near-infrared nanoparticles integrating chemiluminescence technology and signal amplification strategy has been developed for accurate identification of metastatic sentinel lymph nodes in animal tumor models, showing excellent imaging capability for early detection.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Chiao-Juno Chiu, Chien-Chia Liao, Yu-Hsiang Hsu, Bor-Luen Chiang
Summary: Endogenous adult lung SSEA-1(+) cells almost disappear in asthmatic mice, but a unique population of circulating SSEA-1(+) cells is enriched after the challenge phase. These cells play a beneficial role in lung inflammation and structural damage by homing to the lung and inhibiting inflammatory cell infiltration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Miroslava Molitorisova, Martina Sutovska, Ivana Kazimierova, Jana Barborikova, Marta Joskova, Elena Novakova, Sona Franova
Summary: Kaempferol, a flavonol, demonstrated potential in modulating allergic airway inflammation and alleviating asthma features, such as airway hyperreactivity and cough reflex, in an experimental guinea pig model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Finosh G. Thankam, Sharona Sedighim, Rebecca Kuan, Devendra K. Agrawal
Summary: The study suggests that ischemic insults activate epicardial adipose tissue-derived stem cells (EATDS) to secrete extracellular vesicles (EVs) containing regenerative mediators, which can alter gene expression in cardiac fibroblasts (CF). Results showed that the interaction between ischemia-induced EVs and CF cells led to the upregulation of cardiomyocyte-specific transcription factors and the downregulation of fibroblast and cardiac biomarkers, indicating a cardiomyocyte-like phenotype. The study also identified LGALS1, PRDX2, and CCL2 as potent protein mediators involved in regenerative processes. The findings highlight the potential of EATDS-derived EVs and sub-populations for improved cardiac healing following ischemic injury.
TRANSLATIONAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sharona Sedighim, Yiqing Chen, Changlu Xu, Rohit Mohindra, Huinan Liu, Devendra K. Agrawal, Finosh G. Thankam
Summary: In this study, hydrogel scaffolds for cardiac tissue regeneration following myocardial infarction were developed. Both hydrogels displayed superior physiochemical characteristics and were hemocompatible and biocompatible. The in vitro performance of these hydrogels for cardiac tissue engineering applications was appreciable.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Cell Biology
William H. Fang, Victor Bonavida, Devendra K. Agrawal, Finosh G. Thankam
Summary: Hyperlipidemia is a major risk factor for developing atherosclerosis and cardiovascular disease, and it also contributes to an increased incidence of rotator cuff tendon injury (RCTI). Low-density lipoproteins (LDL) and its oxidized form (ox-LDL) play a crucial role in promoting pro-inflammatory responses in the tendon, leading to tendon matrix disorganization. The exact mechanisms underlying RCTI in hyperlipidemia and the effects of ox-LDL on tendon matrix are currently unknown. This review focuses on the implications and future perspectives of LDL/oxLDL in the increased incidence of RCTI.
CELL AND TISSUE RESEARCH
(2023)
Article
Cell Biology
William Fang, Seerat Sekhon, Darren Teramoto, Cameron Fung, Vy La, Cindy Duong, Christian Doescher, An Thai, Finosh G. G. Thankam, Devendra K. K. Agrawal
Summary: The impact of hyperlipidemia on rotator cuff tendon injury (RCTI) is still unclear. This study found that hyperlipidemia caused changes in major extracellular matrix components in tendon tissues and tenocytes. It also affected the expression levels of certain proteins and promoted lipid uptake and the generation of cellular reactive oxygen radicals. Understanding these mechanisms may provide new approaches for managing RCTI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Vikrant Rai, Devendra K. Agrawal
Summary: Treatment of nonhealing diabetic foot ulcers is a major challenge and understanding the effects of sexual dimorphism and other related issues is crucial. However, there is a lack of data in this area. It is important to understand these aspects for choosing appropriate animal models and investigating therapeutic options.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Rebecca Moellmer, Devendra K. Agrawal
Summary: Chronic diabetic foot ulcers (DFUs) can lead to amputation, increased morbidity and mortality, and economic stress. Fibroblast plasticity and heterogeneity, hyperglycemia, inflammatory cytokines, and interactions with other cells in the diabetic wound microenvironment play important roles in DFU healing. The different phenotypes of fibroblasts and their effects on angiogenesis in DFUs have not been thoroughly studied. This review aims to address these gaps in the field.
MOLECULAR BIOLOGY REPORTS
(2023)
Correction
Pharmacology & Pharmacy
Gunimat Samra, Vikrant Rai, Devendra K. Agrawal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Joe Abdo, Devendra K. Agrawal
Summary: Esophageal cancer is a highly fatal disease with limited screening techniques and low survival rates. Non-invasive biomarkers and diagnostic methods are needed for early detection and improved outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sunil K. K. Noothi, Mohamed Radwan Ahmed, Devendra K. K. Agrawal
Summary: Atherosclerotic disease of the coronary and carotid arteries is the leading cause of mortality and morbidity worldwide. Despite advances in treatment and risk factor modification, there is still a residual risk for cardiovascular events. This article discusses the burden of atherosclerotic diseases, highlights the residual risks, and explores the evolving plaques in these arteries using advanced imaging techniques.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Cell Biology
Parth Patel, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a multifactorial inflammatory disease, characterized by plaque formation and hypoxic tissue due to vessel occlusion. Chronic inflammation and altered collagen expression contribute to plaque vulnerability, leading to acute ischemic events. Inflammatory mediators, including TREM-1, TLRs, MMPs, and immune cells, play a critical role in plaque vulnerability.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Prathosh Velpuri, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a disease characterized by the formation of plaques in the blood vessels, resulting in reduced blood flow and oxygen deprivation to organs. Chronic inflammation plays a crucial role in plaque instability and rupture, leading to cardiovascular events. Sirtuins have been identified as potential targets for controlling plaque progression and vulnerability due to their involvement in inflammation and oxidative stress.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Pauline Cheng, Ahmad Rashad, Ankit Gangrade, Natan Roberto de Barros, Ali Khademhosseini, Jonathan Tam, Padmini Varadarajan, Devendra K. Agrawal, Finosh G. Thankam
Summary: Myocardial infarction leads to the loss of cardiomyocytes, but stem cell therapy shows promise in restoring cardiac function. This article discusses the application of different stem cell phenotypes and strategies to promote their differentiation into cardiomyocytes.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Review
Immunology
Armand N. Yazdani, Nathaniel DeMarco, Parth Patel, Arian Abdi, Prathosh Velpuri, Devendra K. Agrawal, Vikrant Rai
Summary: The SARS-CoV-2 virus and the COVID-19 pandemic have had a significant impact on patients with hematological conditions, particularly those who are immunocompromised. Vaccination efforts have increased to protect this vulnerable population, but there are reported side effects and concerns about the vaccine's effectiveness for patients with hematological conditions. This review aims to provide critical hematological information on COVID-19 vaccination for clinicians and to clarify the adverse hematological effects associated with infection and vaccination within the general population.
Article
Pharmacology & Pharmacy
Vikrant Rai, Hoangvi Le, Devendra K. Agrawal
Summary: A non-healing diabetic foot ulcer (DFU) is a significant clinical problem with socioeconomic and psychosocial burdens. Current therapies for DFU, such as wound debridement and growth factors, have limited success in promoting angiogenesis and healing. Poor angiogenesis due to decreased expression of angiogenic mediators and matrix formation leads to nonhealing ulcers and amputation. This article critically reviews existing pro-angiogenic mediators and explores potential novel factors that may enhance angiogenesis and wound healing in DFUs.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Armand N. Yazdani, Michaela Pletsch, Abraham Chorbajian, David Zitser, Vikrant Rai, Devendra K. Agrawal
Summary: To effectively monitor CAD, it is important to identify key biomarkers for assessing disease severity and progression. This review discusses the most relevant markers for monitoring CAD prognosis and highlights the potential of using these markers in therapeutic interventions. By utilizing these markers, healthcare providers can improve patient care, optimize treatment plans, and reduce healthcare costs associated with CAD management.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)