Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

Synthesis of New Lipoic Acid Conjugates and Evaluation of Their Free Radical Scavenging and Neuroprotective Activities

(2014) Maria Laura Bolognesi et al.   Chemical Biology & Drug Design

Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: Role of NMDA receptor

(2014) Pradip K. Kamat et al.   NEUROCHEMISTRY INTERNATIONAL

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

(2013) Su-Yi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

(2013) N. Rajasekar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reversal of Metabolic Deficits by Lipoic Acid in a Triple Transgenic Mouse Model of Alzheimer's Disease: A 13C NMR Study

(2013) Harsh Sancheti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial

(2013) R. J. Kryscio et al.   Journal of Nutrition Health & Aging

(−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus

(2013) Ning Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

NMDA receptors in nervous system diseases

(2013) Qiang Zhou et al.   NEUROPHARMACOLOGY

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

(2013) P.K. Kamat et al.   NEUROSCIENCE

Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats

(2013) Shivika Rai et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

(2013) P R Bharadwaj et al.   Translational Psychiatry

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine

(2012) Mauren Assis Souza et al.   AMINO ACIDS

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Effect of the Proline-Rich Polypeptide Complex/Colostrinin™ on the Enzymatic Antioxidant System

(2012) Agnieszka Zabłocka et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Correlation between Cognitive Functions and Nitric Oxide Levels in Patients with Dementia

(2012) Richa Sachdeva et al.   CLINICAL EEG AND NEUROSCIENCE

Role of APP and Aβ in Synaptic Physiology

(2012) Zilai Wang et al.   Current Alzheimer Research

Creb is modulated in the mouse superior colliculus in developmental and experimentally-induced models of plasticity

(2012) Gabriela Vierci et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation

(2012) Siddhartha Mondragón-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

(2012) Shivika Rai et al.   JOURNAL OF NEUROIMMUNOLOGY

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

(2012) A. M. Kaufman et al.   JOURNAL OF NEUROSCIENCE

Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

(2012) Bruno Vellas et al.   LANCET NEUROLOGY

The BCM theory of synapse modification at 30: interaction of theory with experiment

(2012) Leon N Cooper et al.   NATURE REVIEWS NEUROSCIENCE

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

(2012) Sönke Arlt et al.   NEUROCHEMICAL RESEARCH

Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning

(2012) Federico Fuentes et al.   PLoS One

Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment

(2011) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

(2011) Hongmei Cui et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Neurobiological aspects of Alzheimer's disease

(2011) Kanwaljit Chopra et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Regulation of Long-Term Plasticity Induction by the Channel and C-Terminal Domains of GluN2 Subunits

(2011) Frank Fetterolf et al.   MOLECULAR NEUROBIOLOGY

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain

(2011) Pradeep K. Kamat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice

(2010) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factor

(2010) Xin-Yu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gonadal Steroids do not Affect Apolipoprotein E Expression in Aging Mouse Cerebral Cortex

(2010) Sarika Singh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

(2010) Jaya R.P. Prasanthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia

(2010) A. Chan et al.   Journal of Nutrition Health & Aging

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Dimebon disappointment

(2010) Roy W Jones   Alzheimers Research & Therapy

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Regulation of NMDA receptor Ca2+signalling and synaptic plasticity

(2009) C. Geoffrey Lau et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1

(2009) Ryuji Yamaguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity

(2009) Pradeep K. Kamat et al.   BRAIN RESEARCH

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vitamin E Use Is Associated with Improved Survival in an Alzheimer’s Disease Cohort

(2009) Valory N. Pavlik et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Ginkgo biloba for Preventing Cognitive Decline in Older AdultsA Randomized Trial

(2009) Beth E. Snitz   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)

(2009) Rituraj Niranjan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

(2009) Xing-Ding Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Early biophysics of the NMDA receptor channel

(2009) Philippe Ascher et al.   JOURNAL OF PHYSIOLOGY-LONDON

Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling

(2009) R. Anne McKinney   JOURNAL OF PHYSIOLOGY-LONDON

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats

(2009) Gunjan Saxena et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

(2008) Lindsay C. Reese et al.   AGING CELL

Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study

(2008) Ruth Remington et al.   American Journal of Alzheimers Disease and Other Dementias

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data

(2008) Sandrine Andrieu et al.   Current Alzheimer Research

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

(2008) F. Léveillé et al.   FASEB JOURNAL

Expression and modification of ARC (apoptosis repressor with a CARD domain) is distinctly regulated by oxidative stress in cancer cells

(2008) Yi-Qiang Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms

(2007) Gong-Ping Liu et al.   NEUROBIOLOGY OF AGING