TREM2 in Neurodegenerative Diseases

The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

(2017) Charlotte Jendresen et al.   Journal of Neuroinflammation

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

(2017) Maha Saber et al.   JOURNAL OF NEUROTRAUMA

DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

(2017) Yuki Ozaki et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

(2017) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB

(2017) Rosie Owens et al.   Frontiers in Cellular Neuroscience

Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa

(2017) Mette Marcussen et al.   PLoS One

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

(2016) Juan Domingo Gispert et al.   Alzheimers & Dementia

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease

(2016) Fuhai Song et al.   CURRENT OPINION IN PHARMACOLOGY

CSF sTREM2: marking the tipping point between preclinical AD and dementia?

(2016) Suzanne E Schindler et al.   EMBO Molecular Medicine

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation

(2016) Filip Petković et al.   GLIA

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

(2016) Animesh Alexander Raha et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated TREM2 mRNA expression in leukocytes in schizophrenia but not major depressive disorder

(2016) Yuta Yoshino et al.   JOURNAL OF NEURAL TRANSMISSION

Differential detection of impact site versus rotational site injury by magnetic resonance imaging and microglial morphology in an unrestrained mild closed head injury model

(2016) Alfredo Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)

(2016) Konstantin Glebov et al.   Journal of Neuroinflammation

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

(2016) M. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Parkinsonism, movement disorders and genetics in frontotemporal dementia

(2016) José Fidel Baizabal-Carvallo et al.   Nature Reviews Neurology

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

(2016) Honghua Zheng et al.   NEUROBIOLOGY OF AGING

Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set

(2016) Mahdi Ghani et al.   NEUROBIOLOGY OF AGING

Evaluating pathogenic dementia variants in posterior cortical atrophy

(2016) Minerva M. Carrasquillo et al.   NEUROBIOLOGY OF AGING

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain

(2016) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice

(2016) Chao Jiang et al.   NEUROBIOLOGY OF AGING

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

(2016) Michelle K. Lupton et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson’s disease

(2016) Ting Tan et al.   NEUROSCIENCE LETTERS

TREM2 rare variant p.R47H is not associated with Parkinson's disease

(2016) David Mengel et al.   PARKINSONISM & RELATED DISORDERS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

Vps35-dependent recycling of Trem2 regulates microglial function

(2016) Jie Yin et al.   TRAFFIC

Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

(2016) Leah C. Graham et al.   Scientific Reports

Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population

(2016) Zhiming Li et al.   BMJ Open

In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein

(2016) Farron L. McIntee et al.   Frontiers in Aging Neuroscience

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

(2016) Luisa Möhle et al.   Acta Neuropathologica Communications

Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

(2016) Daniel W. Sirkis et al.   Acta Neuropathologica Communications

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

(2016) Surjyadipta Bhattacharjee et al.   PLoS One

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

Lack of Genetic Association Between TREM2 and Alzheimer’s Disease in East Asian Population

(2015) Man Huang et al.   American Journal of Alzheimers Disease and Other Dementias

Reply

(2015) Joseph M. Replogle et al.   ANNALS OF NEUROLOGY

ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology

(2015) Joseph M. Replogle et al.   ANNALS OF NEUROLOGY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis

(2015) Riem Gawish et al.   FASEB JOURNAL

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

Sporadic adult-onset leucodystrophy with axonal spheroids and pigmented glia with no mutations in the known targeted genes

(2015) Ivan Fernández-Vega et al.   HISTOPATHOLOGY

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

(2015) Kangyun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease

(2015) Nicholas H. Varvel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ

(2015) S. Strobel et al.   JOURNAL OF NEURAL TRANSMISSION

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Assessment of TREM2 rs75932628 association with amyotrophic lateral sclerosis in a Chinese population

(2015) Xueping Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study

(2015) Sanjukta Chakrabarti et al.   MEDICAL ONCOLOGY

Association Study of the TREM2 Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease

(2015) Zohreh Mehrjoo et al.   MEDICAL PRINCIPLES AND PRACTICE

3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5

(2015) Vongsavanh Phongsisay et al.   MOLECULAR IMMUNOLOGY

Campylobacter jejuni targets immunoglobulin-like receptor LMIR5

(2015) Vongsavanh Phongsisay   MOLECULAR IMMUNOLOGY

Evidence for TLR4 and FcRγ–CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors

(2015) Vongsavanh Phongsisay et al.   MOLECULAR IMMUNOLOGY

Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

(2015) Guiyou Liu et al.   MOLECULAR NEUROBIOLOGY

TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

(2015) Sheng Chih Jin et al.   Molecular Neurodegeneration

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

Do glia drive synaptic and cognitive impairment in disease?

(2015) Won-Suk Chung et al.   NATURE NEUROSCIENCE

TREM2 analysis and increased risk of Alzheimer's disease

(2015) Deana Finelli et al.   NEUROBIOLOGY OF AGING

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

(2015) Caihong Zhu et al.   NEUROBIOLOGY OF AGING

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

(2015) Henna Martiskainen et al.   NEUROBIOLOGY OF AGING

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

(2015) Teng Jiang et al.   NEUROBIOLOGY OF AGING

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk

(2015) Samantha L. Rosenthal et al.   NEUROBIOLOGY OF AGING

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

(2015) Iliya Lefterov et al.   NEUROBIOLOGY OF DISEASE

Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease

(2015) Atsushi Sasaki et al.   NEUROGENETICS

TREM2 variants and risk of Alzheimer’s disease: a meta-analysis

(2015) Yanjun Lu et al.   NEUROLOGICAL SCIENCES

Assessment of TREM2 rs75932628 association with Parkinson’s disease and multiple system atrophy in a Chinese population

(2015) Yongping Chen et al.   NEUROLOGICAL SCIENCES

Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis

(2015) Corinna Preusse et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid

(2015) V. Porrini et al.   NEUROSCIENCE

TREM2 R47H variant and risk of essential tremor: A cross-sectional international multicenter study

(2015) Sara Ortega-Cubero et al.   PARKINSONISM & RELATED DISORDERS

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

(2015) Y. Zhang et al.   Science Signaling

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

(2015) Ji-Seon Park et al.   TRAFFIC

Diagnostic marker signature for esophageal cancer from transcriptome analysis

(2015) Ute Warnecke-Eberz et al.   TUMOR BIOLOGY

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma

(2015) Xiao-Qiang Wang et al.   Oncotarget

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

R47H Variant ofTREM2Associated With Alzheimer Disease in a Large Late-Onset Family

(2015) Olena Korvatska et al.   JAMA Neurology

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

(2015) Y. Zhang et al.   Science Signaling

A Case of Nasu-Hakola Disease without Fractures or Consanguinity Diagnosed Using Exome Sequencing and Treated with Sodium Valproate

(2015) Kiyohiro Yamazaki et al.   Clinical Psychopharmacology and Neuroscience

Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing

(2015) Luiz Miguel Camargo et al.   PLoS One

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

(2014) Catherine F. Slattery et al.   Alzheimers & Dementia

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

(2014) Lih-Fen Lue et al.   BRAIN PATHOLOGY

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity

(2014) Min Park et al.   DIABETES

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Microglial activation mediates host neuronal survival induced by neural stem cells

(2014) Hui-Mei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

(2014) Xiaoyan Hu et al.   Molecular Neurodegeneration

Intratracheal instillation of single-wall carbon nanotubes in the rat lung induces time-dependent changes in gene expression

(2014) Katsuhide Fujita et al.   Nanotoxicology

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

(2014) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

(2014) Bin Jiao et al.   NEUROBIOLOGY OF AGING

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

(2014) Mathias Thelen et al.   NEUROBIOLOGY OF AGING

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

(2014) Elkin O. Luis et al.   NEUROBIOLOGY OF AGING

Association study ofTREM2polymorphism rs75932628 with late-onset Alzheimer’s disease in Chinese Han population

(2014) Jianfang Ma et al.   NEUROLOGICAL RESEARCH

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

(2014) B. V. Hooli et al.   NEUROLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Genetics of Alzheimer’s Disease

(2014) Rita Guerreiro et al.   Neurotherapeutics

LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains

(2014) Jun-ichi Satoh et al.   Orphanet Journal of Rare Diseases

Molecular Characterization of Antigen-Peptide Pulsed Dendritic Cells: Immature Dendritic Cells Develop a Distinct Molecular Profile when Pulsed with Antigen Peptide

(2014) Amy X. Yang et al.   PLoS One

Impact of Cigarette Smoke on the Human and Mouse Lungs: A Gene-Expression Comparison Study

(2014) Mathieu C. Morissette et al.   PLoS One

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

(2014) Zainularifeen Abduljaleel et al.   PLoS One

Gene-Based Rare Allele Analysis Identified a Risk Gene of Alzheimer’s Disease

(2014) Jong Hun Kim et al.   PLoS One

Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases

(2014) Daniel L. Kober et al.   PROTEIN EXPRESSION AND PURIFICATION

TREM-2 Promotes Macrophage-Mediated Eradication ofPseudomonas aeruginosavia a PI3K/Akt Pathway

(2014) M. Zhu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Triggering Receptor Expressed on Myeloid Cells-2 Protects against Polymicrobial Sepsis by Enhancing Bacterial Clearance

(2013) QiXing Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP)

(2013) Simone König et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

TREM2: a new risk factor for Alzheimer's disease

(2013) RR Singaraja   CLINICAL GENETICS

Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes

(2013) Vanessa Montalvo et al.   IMMUNOLOGY

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line

(2013) Peter N. Alexandrov et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

(2013) Dorit Trudler et al.   JOURNAL OF NEUROCHEMISTRY

Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): A new report of an Italian woman and review of the literature

(2013) Veronika Bock et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

(2013) Serena Lattante et al.   NEUROBIOLOGY OF AGING

Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study

(2013) Josue D. Gonzalez Murcia et al.   NEUROBIOLOGY OF AGING

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

(2013) Margarita Giraldo et al.   NEUROBIOLOGY OF AGING

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention

(2013) Corinne D. Engelman et al.   NEUROBIOLOGY OF AGING

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

(2013) Agustín Ruiz et al.   NEUROBIOLOGY OF AGING

Heterozygous TREM2 mutations in frontotemporal dementia

(2013) Barbara Borroni et al.   NEUROBIOLOGY OF AGING

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

(2013) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

Missense variant in TREML2 protects against Alzheimer's disease

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a

(2013) Yuhai Zhao et al.   NEUROREPORT

TREM2 and Neurodegenerative Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

(2013) Matthias W. Sieber et al.   PLoS One

Analysis of the Host Transcriptome from Demyelinating Spinal Cord of Murine Coronavirus-Infected Mice

(2013) Ruth Elliott et al.   PLoS One

Differential Modulation of TREM2 Protein during Postnatal Brain Development in Mice

(2013) Mariela Chertoff et al.   PLoS One

TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection

(2013) L. A. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages

(2013) Q. Peng et al.   Science Signaling

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women

(2012) Alex P. Reiner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation

(2012) M.S.F. Zawawi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response

(2012) Carmen Correale et al.   GASTROENTEROLOGY

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

(2012) Bettina Linnartz et al.   GLIA

TLT-1s, Alternative Transcripts of Triggering Receptor Expressed on Myeloid Cell-like Transcript-1 (TLT-1), Inhibits the Triggering Receptor Expressed on Myeloid Cell-2 (TREM-2)-mediated Signaling Pathway during Osteoclastogenesis

(2012) Soo-Hyun Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E proteins regulate osteoclast maturation and survival

(2012) Courtney L Long et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

(2012) K. Otero et al.   JOURNAL OF IMMUNOLOGY

Acute injury in the peripheral nervous system triggers an alternative macrophage response

(2012) Elke Ydens et al.   Journal of Neuroinflammation

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunomodulation by Transplanted Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors in Experimental Autoimmune Encephalomyelitis

(2012) Heechul Kim et al.   STEM CELLS

The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints

(2012) Tania N Crotti et al.   ARTHRITIS RESEARCH & THERAPY

Gene Expression Profile of THP-1 Monocytes Following Knockdown of DAP12, A Causative Gene for Nasu-Hakola Disease

(2011) Jun-ichi Satoh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy

(2011) Shannon K. O'Neill et al.   IMMUNITY

Specific lipid recognition is a general feature of CD300 and TREM molecules

(2011) John P. Cannon et al.   IMMUNOGENETICS

A Japanese Case with Nasu-Hakola Disease of DAP12 Gene Mutation Exhibiting Precuneus Hypoperfusion

(2011) Kiyotaka Nakamagoe et al.   INTERNAL MEDICINE

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

(2011) K. Lunnon et al.   JOURNAL OF IMMUNOLOGY

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Adipose tissue transcriptome changes during obesity development in female dogs

(2011) Ryan W. Grant et al.   PHYSIOLOGICAL GENOMICS

Inflammatory response in rat lungs with recurrent exposure to welding fumes

(2011) Jung-Hwa Oh et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice

(2010) Saki Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells

(2010) Liina Tserel et al.   BMC GENOMICS

Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family

(2010) Y. Numasawa et al.   EUROPEAN JOURNAL OF NEUROLOGY

DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2

(2010) L. L. Koth et al.   JOURNAL OF IMMUNOLOGY

Immunohistochemical characterization of microglia in Nasu-Hakola disease brains

(2010) Jun-ichi Satoh et al.   NEUROPATHOLOGY

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease

(2010) Yair Fisher et al.   PLoS One

Vasoactive intestinal peptide re-balances TREM-1/TREM-2 ratio in acute lung injury

(2010) Guo-Ying Sun et al.   REGULATORY PEPTIDES

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation

(2009) Jae-Ho Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TREM and TREM-like receptors in inflammation and disease

(2009) Jill W Ford et al.   CURRENT OPINION IN IMMUNOLOGY

Lectins as pattern recognition molecules: The effects of epitope density in innate immunity

(2009) T. K Dam et al.   GLYCOBIOLOGY

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

(2009) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

Microarray-Based Analysis of the Lung Recovery Process After Stainless-Steel Welding Fume Exposure in Sprague–Dawley Rats

(2009) Jung-Hwa Oh et al.   INHALATION TOXICOLOGY

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

(2009) Niklas Mattsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells

(2009) Gillian C. Whittaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-  in Human Osteoclast Precursors

(2009) J.-D. Ji et al.   JOURNAL OF IMMUNOLOGY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Gene expression profile of the bone microenvironment in human fragility fracture bone

(2008) B. Hopwood et al.   BONE

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION

The Innate Immune Response to Salmonella enterica Serovar Typhimurium by Macrophages Is Dependent on TREM2-DAP12

(2008) J. F. Charles et al.   INFECTION AND IMMUNITY

No evidence for shared etiology in two demyelinative disorders, MS and PLOSL

(2008) Anna-Maija Sulonen et al.   JOURNAL OF NEUROIMMUNOLOGY

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

(2008) J. Cameron Thrash et al.   NEUROCHEMICAL RESEARCH

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA