The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk

(2015) Samantha L. Rosenthal et al.   NEUROBIOLOGY OF AGING

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

(2015) Ji-Seon Park et al.   TRAFFIC

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

(2014) Courtney Lane-Donovan et al.   NEURON

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Heterozygous TREM2 mutations in frontotemporal dementia

(2013) Barbara Borroni et al.   NEUROBIOLOGY OF AGING

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

(2013) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Specific lipid recognition is a general feature of CD300 and TREM molecules

(2011) John P. Cannon et al.   IMMUNOGENETICS

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION