Cholesterol Metabolism in Aging and Age-Related Disorders

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

(2022) Thomas E. Mahan et al.   Molecular Neurodegeneration

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

(2022) Andrew C. Yang et al.   NATURE

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level

(2022) Erik C. B. Johnson et al.   NATURE NEUROSCIENCE

Local cholesterol metabolism orchestrates remyelination

(2022) Stefan A. Berghoff et al.   TRENDS IN NEUROSCIENCES

New insights into the genetic etiology of Alzheimer’s disease and related dementias

(2022) Céline Bellenguez et al.   NATURE GENETICS

Cholesterol determines the cytosolic entry and seeded aggregation of tau

(2022) Benjamin J. Tuck et al.   Cell Reports

Diploid hepatocytes drive physiological liver renewal in adult humans

(2022) Paula Heinke et al.   Cell Systems

Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations

(2021) Siddhartha Banerjee et al.   ACS Chemical Neuroscience

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

(2021) Lijun Dai et al.   MOLECULAR NEUROBIOLOGY

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes

(2021) Elina Ikonen et al.   DEVELOPMENTAL CELL

Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss

(2021) Tatiana Burrinha et al.   JOURNAL OF CELL SCIENCE

Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis

(2021) Tanvi Dayanand Pingale et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

(2021) Chao Wang et al.   NEURON

Development of human white matter pathways in utero over the second and third trimester

(2021) Siân Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the relationship between BMI across adulthood and late life brain pathologies

(2021) Christopher A. Lane et al.   Alzheimers Research & Therapy

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

(2021) Melissa K. Edler et al.   Cells

Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population‐based cohort study

(2021) Ruixue Song et al.   Alzheimers & Dementia

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research

(2021) Anand Rohatgi et al.   CIRCULATION

Cholesterol efflux pathways, inflammation, and atherosclerosis

(2021) Anouk G. Groenen et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Clemastine attenuates AD-like pathology in an AD model mouse via enhancing mTOR-mediated autophagy

(2021) Zhen-Yu Li et al.   EXPERIMENTAL NEUROLOGY

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

(2021) Garyfallia Gouna et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

(2021) Jing-Fei Chen et al.   NEURON

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

(2021) Hao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes

(2021) Yue Liu et al.   Translational Psychiatry

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

(2021) Sabine C. Konings et al.   Frontiers in Neuroscience

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

(2021) Shady Estfanous et al.   Frontiers in Immunology

Microglia‐specific ApoE knock‐out does not alter Alzheimer's disease plaque pathogenesis or gene expression

(2021) Caden M. Henningfield et al.   GLIA

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

(2021) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

(2021) Stefan A. Berghoff et al.   Cell Reports

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

(2021) Madeleine Dorsch et al.   Cell Reports

Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux

(2021) Keren E. Shapira et al.   Cell Death Discovery

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

(2020) Zhen Sun et al.   Aging-US

Associations between Serum Levels of Cholesterol and Survival to Age 90 in Postmenopausal Women

(2020) Adam X. Maihofer et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Changes in the oligodendrocyte progenitor cell proteome with ageing

(2020) Alerie G de la Fuente et al.   MOLECULAR & CELLULAR PROTEOMICS

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

The Cognitive Effects of Statins are Modified by Age

(2020) Ahmed M. Alsehli et al.   Scientific Reports

Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors

(2020) Yuqin Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

(2020) Sandeep R. Das et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

(2020) Michael N. Trinh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

(2020) Robin J.M. Franklin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Redefining Microglial Identity in Health and Disease at Single-Cell Resolution

(2020) Francesca Provenzano et al.   TRENDS IN MOLECULAR MEDICINE

Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

(2020) Qian Zhang et al.   Nature Communications

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer’s cerebral pathology and clinical disease progression

(2020) Tabea Jahn et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cholesterol Lowering Drugs Reduce APP Processing to Aβ by Inducing APP Dimerization

(2020) Vanessa F. Langness et al.   MOLECULAR BIOLOGY OF THE CELL

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

(2020) Stefan A. Berghoff et al.   NATURE NEUROSCIENCE

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

(2020) Yun Chen et al.   NEURON

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

(2020) Xinwen Zhang et al.   Science Advances

Statin Toxicity

(2019) Natalie C. Ward et al.   CIRCULATION RESEARCH

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

(2019) Celia G. Fernandez et al.   Frontiers in Aging Neuroscience

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

7-Ketocholesterol in disease and aging

(2019) Amelia Anderson et al.   Redox Biology

Lipid lowering and Alzheimer disease risk: A mendelian randomization study

(2019) Dylan M. Williams et al.   ANNALS OF NEUROLOGY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

(2018) Elisabet Barbero-Camps et al.   Autophagy

Cholesterol efflux capacity does not associate with coronary calcium, plaque vulnerability, and telomere length in healthy octogenarians

(2018) Francesca Zimetti et al.   JOURNAL OF LIPID RESEARCH

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

(2018) Evan D. Muse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Trends in Diet and Alzheimer's Disease During the Nutrition Transition in Japan and Developing Countries

(2018) William B. Grant   JOURNAL OF ALZHEIMERS DISEASE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

(2018) Jie Luo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

Demographics, phenotypic health characteristics and genetic analysis of centenarians in China

(2017) Yi Zeng et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Trends in dementia prevalence, incidence, and survival rate in a Japanese community

(2017) Tomoyuki Ohara et al.   NEUROLOGY

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

(2017) Heather A. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

Long-term statin therapy could be efficacious in reducing the lipoprotein (a) levels in patients with coronary artery disease modified by some traditional risk factors

(2017) Ming-Xing Xu et al.   Journal of Thoracic Disease

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

Statin-Associated Side Effects

(2016) Paul D. Thompson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

(2016) Jiho Jang et al.   Nature Communications

Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: Data from the Chinese Longitudinal Healthy Longevity Survey

(2015) Yue-Bin Lv et al.   ATHEROSCLEROSIS

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Comparison of the Mouse and Human Lipoproteome: Suitability of the Mouse Model for Studies of Human Lipoproteins

(2015) Scott M. Gordon et al.   JOURNAL OF PROTEOME RESEARCH

Involvement of oxysterols in age-related diseases and ageing processes

(2014) Amira Zarrouk et al.   AGEING RESEARCH REVIEWS

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Longitudinal Trajectories of Cholesterol from Midlife through Late Life according to Apolipoprotein E Allele Status

(2014) Brian Downer et al.   International Journal of Environmental Research and Public Health

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation

(2013) Chao Zhou et al.   PLoS One

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth

(2012) U. Funfschilling et al.   JOURNAL OF NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Prognostic significance of serum cholesterol, lathosterol, and sitosterol in old age; a 17-year population study

(2011) Reijo S. Tilvis et al.   ANNALS OF MEDICINE

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality

(2010) Guenther Silbernagel et al.   JOURNAL OF LIPID RESEARCH

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

(2009) L. Abi-Mosleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuroglial population in the primary visual cortex of the aging rhesus monkey

(2008) Alan Peters et al.   GLIA

Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro

(2008) Mauricio G. Martin et al.   MOLECULAR BIOLOGY OF THE CELL

Synapses are lost during aging in the primate prefrontal cortex

(2007) A. Peters et al.   NEUROSCIENCE