Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genes

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease

(2019) Joseph O. Ojo et al.   Frontiers in Neuroscience

Plasma lipidome variation during the second half of the human lifespan is associated with age and sex but minimally with BMI

(2019) Matthew Wai Kin Wong et al.   PLoS One

ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aß42, levels in non-demented elderly

(2019) Rosalinde E.R. Slot et al.   NEUROBIOLOGY OF AGING

Role of cholesterol and sphingolipids in brain development and neurological diseases

(2019) Ghulam Hussain et al.   Lipids in Health and Disease

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms

(2019) Minna Oksanen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease

(2019) Xue Meng et al.   Alzheimers Research & Therapy

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis

(2018) Liana G. Apostolova et al.   JAMA Neurology

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients

(2018) Mathias J. Gerl et al.   Scientific Reports

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

Inverse Phosphatidylcholine/Phosphatidylinositol Levels as Peripheral Biomarkers and Phosphatidylcholine/Lysophosphatidylethanolamine-Phosphatidylserine as Hippocampal Indicator of Postischemic Cognitive Impairment in Rats

(2018) Angelica Maria Sabogal-Guáqueta et al.   Frontiers in Neuroscience

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease

(2017) Min Jeong Wang et al.   Alzheimers Research & Therapy

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

(2017) Anne S. B. Olsen et al.   Open Biology

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

(2016) Julien Chapuis et al.   ACTA NEUROPATHOLOGICA

Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

(2016) Ramon Casanova et al.   Alzheimers & Dementia

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

(2016) Jingshu Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

(2016) Leslie M. Ramirez et al.   NEUROBIOLOGY OF AGING

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

(2016) Karen A. Mather et al.   Scientific Reports

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds

(2015) Niku Oksala et al.   ATHEROSCLEROSIS

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia

(2015) Karen A. Mather et al.   PLoS One

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease

(2015) P Proitsi et al.   Translational Psychiatry

Regularization Paths for Generalized Linear Models via Coordinate Descent

(2015) Jerome Friedman et al.   Journal of Statistical Software

Lipidomics: Analysis of the Lipid Composition of Cells and Subcellular Organelles by Electrospray Ionization Mass Spectrometry

(2014) Britta Brügger   Annual Review of Biochemistry

Is Alzheimer's disease a systemic disease?

(2014) Jill K. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

(2013) J. M. Shulman et al.   HUMAN MOLECULAR GENETICS

SORL1genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese

(2013) Xin Gao et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

(2013) Yoko Tajima et al.   Lipids in Health and Disease

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

(2013) Luke Whiley et al.   NEUROBIOLOGY OF AGING

Amyloid Precursor Protein Is an Autonomous Growth Cone Adhesion Molecule Engaged in Contact Guidance

(2013) Lucas J. Sosa et al.   PLoS One

MicroRNA-34a Enhances T Cell Activation by Targeting Diacylglycerol Kinase ζ

(2013) Jinwook Shin et al.   PLoS One

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

(2011) Leila Hejazi et al.   BIOCHEMICAL JOURNAL

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

(2011) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss

(2010) Michelle M. Mielke et al.   Alzheimers & Dementia

The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70–90 years

(2010) Perminder S. Sachdev et al.   INTERNATIONAL PSYCHOGERIATRICS

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?

(2010) Michelle M. Mielke et al.   NEUROMOLECULAR MEDICINE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans

(2009) Adebowale Adeyemo et al.   PLoS Genetics