Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Role of metabolic programming in the modulation of microglia phagocytosis by lipids

(2018) A. Nadjar   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

Progranulin in the hematopoietic compartment protects mice from atherosclerosis

(2018) Andrew D. Nguyen et al.   ATHEROSCLEROSIS

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases

(2017) Xirong Hu et al.   NEUROCHEMICAL RESEARCH

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

(2017) Bret M. Evers et al.   Cell Reports

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model

(2016) Pingting Liu et al.   Disease Models & Mechanisms

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

(2016) Richard M Deans et al.   Nature Chemical Biology

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes

(2016) Marilia Kimie Shimabukuro et al.   Scientific Reports

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology

(2015) Philip Chang et al.   Journal of Neuroinflammation

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Lipopolysaccharide-Stimulated Transglutaminase 2 Expression Enhances Endocytosis Activity in the Mouse Microglial Cell Line BV-2

(2015) Kenji Kawabe et al.   NEUROIMMUNOMODULATION

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Shedding new light on lipid functions with CARS and SRS microscopy

(2014) Yong Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

(2014) E. Tsika et al.   HUMAN MOLECULAR GENETICS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia

(2012) Armen Khatchadourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

BODIPY dyes in photodynamic therapy

(2012) Anyanee Kamkaew et al.   CHEMICAL SOCIETY REVIEWS

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Core features of frontotemporal dementia recapitulated in progranulin knockout mice

(2011) N. Ghoshal et al.   NEUROBIOLOGY OF DISEASE

Cross-Talk between Macrophage Migration Inhibitory Factor and Eotaxin in Allergic Eosinophil Activation Forms Leukotriene C4–Synthesizing Lipid Bodies

(2010) Adriana Vieira-de-Abreu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lipids in Alzheimer's disease: A century-old story

(2010) Paul Foley   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

(2010) Prakash G. Chandak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY