Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)

(2021) Yuta Takaichi et al.   Acta Neuropathologica Communications

Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats

(2021) Brittney Yegla et al.   GLIA

A novel tau‐based rhesus monkey model of Alzheimer's pathogenesis

(2021) Danielle Beckman et al.   Alzheimers & Dementia

Uncovering sex differences of rodent microglia

(2021) Jinming Han et al.   Journal of Neuroinflammation

Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri

(2020) Juan D. Rodriguez‐Callejas et al.   GLIA

Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles

(2020) Xavier Gallart-Palau et al.   Alzheimers Research & Therapy

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease

(2020) Daniel T. Ohm et al.   BRAIN PATHOLOGY

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

(2020) Zhi Ruan et al.   Molecular Neurodegeneration

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging vs hypoxia

(2020) Simona Sacchini et al.   Biology Open

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

(2019) Syam Nair et al.   GLIA

Cyanobacterial neurotoxin BMAA and brain pathology in stranded dolphins

(2019) David A. Davis et al.   PLoS One

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets

(2019) Juan de Dios Rodríguez-Callejas et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Interplay between Mitophagy and inflammasome in Neurological Disorders

(2019) Radhika Kesharwani et al.   ACS Chemical Neuroscience

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories

(2019) Tamar Gefen et al.   Frontiers in Aging Neuroscience

Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies

(2019) Jing Zhang et al.   AGING CELL

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Tau isoform expression and phosphorylation in marmoset brains

(2019) Govinda Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BIN1 favors the spreading of Tau via extracellular vesicles

(2019) Andrea Crotti et al.   Scientific Reports

Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

(2019) Kristen D. Onos et al.   PLoS Genetics

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

(2019) Marianna D’Anca et al.   Frontiers in Aging Neuroscience

Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease?

(2019) Sonja Prpar Mihevc et al.   Frontiers in Neuroscience

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys

(2019) Veronica Go et al.   GeroScience

Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging

(2019) Danielle Beckman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

(2019) Amy F. T. Arnsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

(2018) Constantinos D. Paspalas et al.   Alzheimers & Dementia

Alzheimer's disease in humans and other animals: A consequence of postreproductive life span and longevity rather than aging

(2018) Danièlle Gunn-Moore et al.   Alzheimers & Dementia

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer’s Disease Research?

(2018) Yu Fan et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammation leads to distinct populations of extracellular vesicles from microglia

(2018) Yiyi Yang et al.   Journal of Neuroinflammation

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease

(2018) Paige E. Cramer et al.   NEUROBIOLOGY OF AGING

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

(2018) Rosa C. Paolicelli et al.   NEUROSCIENCE

Stereological Analysis of Microglia in Aged Male and Female Fischer 344 Rats in Socially Relevant Brain Regions

(2018) Amy E. Perkins et al.   NEUROSCIENCE

An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers

(2018) Clare Rusbridge et al.   Frontiers in Aging Neuroscience

Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex

(2018) Thomas E. Chan et al.   Frontiers in Aging Neuroscience

Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation

(2018) Alain Meyer et al.   Frontiers in Immunology

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

(2018) Angela Marie Floden et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees

(2018) Melissa K. Edler et al.   JOURNAL OF COMPARATIVE NEUROLOGY

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

(2018) Isabel Barroeta-Espar et al.   NEUROBIOLOGY OF DISEASE

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases

(2017) Paula C. Bickford et al.   EXPERIMENTAL GERONTOLOGY

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Exosomes: From Garbage Bins to Promising Therapeutic Targets

(2017) Mohammed H. Rashed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Old Maids: Aging and Its Impact on Microglia Function

(2017) Edward Koellhoffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid-Related Imaging Abnormalities in an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

(2017) Eric Heuer et al.   JOURNAL OF ALZHEIMERS DISEASE

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Exosome-based immunomodulation during aging: A nano-perspective on inflamm-aging

(2017) Francesco Prattichizzo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

(2017) Ruohe Zhao et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rod-shaped microglia morphology is associated with aging in 2 human autopsy series

(2017) Adam D. Bachstetter et al.   NEUROBIOLOGY OF AGING

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease markers in the aged sheep ( Ovis aries )

(2017) Suzanne J. Reid et al.   NEUROBIOLOGY OF AGING

Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease

(2017) Melissa K. Edler et al.   NEUROBIOLOGY OF AGING

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

(2017) Divya Raj et al.   Frontiers in Molecular Neuroscience

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

(2017) Eli Shobin et al.   GeroScience

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Glial cell morphological and density changes through the lifespan of rhesus macaques

(2016) Katelyn N. Robillard et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model

(2016) Sung Hoon Baik et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Characterization of Amyloid-β Deposits in Bovine Brains

(2016) Elena Vallino Costassa et al.   JOURNAL OF ALZHEIMERS DISEASE

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease

(2016) Ingrid H. Philippens et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Relation between canine cognitive dysfunction and age-related brain lesions

(2016) Makiko OZAWA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II

(2016) Christina Tegeler et al.   NEUROBIOLOGY OF AGING

Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas ( Gorilla beringei beringei )

(2016) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

(2016) S. A. Youssef et al.   VETERINARY PATHOLOGY

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset

(2016) Juan D. Rodriguez-Callejas et al.   Frontiers in Aging Neuroscience

Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer’s Disease

(2015) Antigoni Ekonomou et al.   BIOLOGICAL PSYCHIATRY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

IFN-γ promotes τ phosphorylation without affecting mature tangles

(2015) Andrew Li et al.   FASEB JOURNAL

Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment

(2015) Tomas Smolek et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

(2015) Franziska Schmidt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis

(2015) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Amyloid biomarkers in Alzheimer's disease

(2015) Kaj Blennow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

The domestic cat as a natural animal model of Alzheimer’s disease

(2015) James K. Chambers et al.   Acta Neuropathologica Communications

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

(2015) Levi B. Wood et al.   Scientific Reports

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

(2014) Juan E. Tichauer et al.   BRAIN BEHAVIOR AND IMMUNITY

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-4 Signaling Drives a Unique Arginase+/IL-1 + Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4R  after Traumatic Spinal Cord Injury

(2014) A. M. Fenn et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Response to Watkins and Hutchinson

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition

(2014) Michael W. Marlatt et al.   NEURAL PLASTICITY

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

(2013) Elina Zotova et al.   BRAIN

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets

(2013) Chenere P. Ramsey et al.   EXPERIMENTAL NEUROLOGY

Classical and unconventional pathways of vesicular release in microglia

(2013) Ilaria Prada et al.   GLIA

The Marmoset as a Model of Aging and Age-Related Diseases

(2013) S. D. Tardif et al.   ILAR JOURNAL

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)

(2013) Sylvia E. Perez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs

(2013) Livia Garzetti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Development of amyloid burden in African Green monkeys

(2013) Sergey Kalinin et al.   NEUROBIOLOGY OF AGING

Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain

(2013) Kristyn Bates et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

(2013) I. Suridjan et al.   NEUROIMAGE

Microglia as Dynamic and Essential Components of the Amyloid Hypothesis

(2013) Sam Gandy et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease

(2013) J.J. Rodríguez et al.   NEUROSCIENCE LETTERS

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

(2013) Wai T. Wong   Frontiers in Cellular Neuroscience

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing

(2013) Manuela Martins-Green et al.   Advances in Wound Care

Distribution of microglia in the postnatal murine nigrostriatal system

(2012) Ahmed Sharaf et al.   CELL AND TISSUE RESEARCH

Aging is associated with circulating cytokine dysregulation

(2012) Lorena Álvarez-Rodríguez et al.   CELLULAR IMMUNOLOGY

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

(2012) Eric Heuer et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

(2012) Marie-Ève Tremblay et al.   GLIA

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

(2012) Elizabeth S Didier et al.   Immunity & Ageing

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

(2011) C.-H. Yu et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Sex differences in microglial colonization of the developing rat brain

(2011) Jaclyn M. Schwarz et al.   JOURNAL OF NEUROCHEMISTRY

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

CD45 Deficiency Drives Amyloid-  Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

(2011) Y. Zhu et al.   JOURNAL OF NEUROSCIENCE

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation

(2011) Arianna Bellucci et al.   Neurodegenerative Diseases

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

(2011) Balázs Gulyás et al.   NEUROIMAGE

Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons

(2011) M. Ndung'u et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

(2011) S. Serizawa et al.   VETERINARY PATHOLOGY

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

Neuronal and Axonal Loss Are Selectively Linked to Fibrillar Amyloid-β within Plaques of the Aged Primate Cerebral Cortex

(2010) Palak Shah et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

(2010) J J Rodríguez et al.   Cell Death & Disease

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

(2009) Michael A. Mastrangelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Powerful beneficial effects of macrophage colony-stimulating factor on  -amyloid deposition and cognitive impairment in Alzheimer's disease

(2009) V. Boissonneault et al.   BRAIN

Central inhibition of interleukin-1β ameliorates sickness behavior in aged mice

(2009) Jayne Abraham et al.   BRAIN BEHAVIOR AND IMMUNITY

Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

(2009) Naoto Oikawa et al.   BRAIN RESEARCH

Visualization of Brain Amyloid and Microglial Activation in Mouse Models of Alzheimers Disease

(2009) Makoto Higuchi   Current Alzheimer Research

Immune and behavioral consequences of microglial reactivity in the aged brain

(2009) A. M. Wynne et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Parenchymal and Vascular Lesions in Ageing Equine Brains: Histological and Immunohistochemical Studies

(2009) M.T. Capucchio et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Life and Death of Microglia

(2009) Wolfgang J. Streit et al.   Journal of Neuroimmune Pharmacology

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex

(2009) Elaine Leung et al.   NEUROBIOLOGY OF AGING

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

(2008) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

The neuroglial population in the primary visual cortex of the aging rhesus monkey

(2008) Alan Peters et al.   GLIA

Tauopathy with paired helical filaments in an aged chimpanzee

(2008) Rebecca F. Rosen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Nonviral DNA Vaccination Augments Microglial Phagocytosis of β-Amyloid Deposits as a Major Clearance Pathway in an Alzheimer Disease Mouse Model

(2008) Yoshio Okura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

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Cerebral Amyloid-Beta Protein Accumulation with Aging in Cotton-Top Tamarins: A Model of Early Alzheimer's Disease?

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