Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

(2020) Eylan Yutuc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into small molecule action on Frizzleds

(2020) Paweł Kozielewicz et al.   Nature Communications

Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation

(2020) Hiroshi Matsuoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

(2019) Spyridon Theofilopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical mechanisms of vertebrate hedgehog signaling

(2019) Jennifer H. Kong et al.   DEVELOPMENT

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

(2019) William J. Griffiths et al.   FREE RADICAL BIOLOGY AND MEDICINE

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

(2019) Clévio Nóbrega et al.   ACTA NEUROPATHOLOGICA

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

(2019) Radhia Kacher et al.   BRAIN

11β-hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor gamma

(2019) Katharina R. Beck et al.   JOURNAL OF LIPID RESEARCH

Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2

(2019) Katharina R. Beck et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

(2019) Xiaofeng Qi et al.   NATURE

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

(2019) Ishan Deshpande et al.   NATURE

Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

(2019) Anna Meljon et al.   Biomolecules

Oxysterols in Autoimmunity

(2019) Donovan Duc et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing

(2019) Liang Chen et al.   JOURNAL OF LIPID RESEARCH

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

(2019) Mingzhi Han et al.   EMBO Molecular Medicine

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

(2019) Maia Kinnebrew et al.   eLife

mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5

(2019) Stefan Hauser et al.   Molecular Therapy-Methods & Clinical Development

Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites

(2019) William J. Griffiths et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma

(2018) Jonas Abdel-Khalik et al.   BIOCHIMIE

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

(2018) E.R. de Kloet et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma

(2018) William J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Detection of estradiol in rat brain tissues: Contribution of local versus systemic production

(2018) Junyi Li et al.   PSYCHONEUROENDOCRINOLOGY

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

(2017) Maud Voisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

(2017) Gregory Segala et al.   Nature Communications

EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis

(2017) Aurélie S. Clottu et al.   Cell Reports

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

(2017) Florian Wanke et al.   Cell Reports

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

RORγt Expression and Lymphoid Neogenesis in the Brain of Patients with Secondary Progressive Multiple Sclerosis

(2016) Barbara Serafini et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients

(2016) Peter J. Crick et al.   MOLECULAR NEUROBIOLOGY

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols

(2016) Navdar Sever et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm

(2015) Durba Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

(2015) Marie-Anne Burlot et al.   HUMAN MOLECULAR GENETICS

A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid

(2015) Rohini Sidhu et al.   JOURNAL OF LIPID RESEARCH

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

Cholesterol metabolites exported from human brain

(2015) Luigi Iuliano et al.   STEROIDS

Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse

(2014) Anna Meljon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Quantitative Charge-Tags for Sterol and Oxysterol Analysis

(2014) P. J. Crick et al.   CLINICAL CHEMISTRY

Oxysterol-EBI2 signaling in immune regulation and viral infection

(2014) Viktorija Daugvilaite et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain

(2014) Ahmed A. Saeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholestenoic acids regulate motor neuron survival via liver X receptors

(2014) Spyridon Theofilopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver disease in infancy caused by oxysterol 7α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid

(2014) Dongling Dai et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1

(2014) Sandeep Goyal et al.   JOURNAL OF LIPID RESEARCH

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols

(2014) Hanne Roberg-Larsen et al.   JOURNAL OF LIPID RESEARCH

Estrogen receptor β and Liver X receptor β: biology and therapeutic potential in CNS diseases

(2014) M Warner et al.   MOLECULAR PSYCHIATRY

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

(2014) A. R. Stiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation

(2014) P. Soroosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

(2014) Suzanne E. Wardell et al.   STEROIDS

Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

(2013) Diego F. Cobice et al.   ANALYTICAL CHEMISTRY

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

(2013) Tijana Mitić et al.   BIOCHEMICAL PHARMACOLOGY

Analysis by liquid chromatography–mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7Δ3-5/T93M mouse: A model of Smith–Lemli–Opitz syndrome

(2013) Anna Meljon et al.   BIOCHEMICAL PHARMACOLOGY

Cerebrotendinous xanthomatosis

(2013) Ingemar Björkhem   CURRENT OPINION IN LIPIDOLOGY

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER  Signaling on Astrocytes But Not through ER  Signaling on Astrocytes or Neurons

(2013) R. D. Spence et al.   JOURNAL OF NEUROSCIENCE

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

(2013) Wan-fu Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

(2013) Sigrid Nachtergaele et al.   eLife

Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma

(2012) William J. Griffiths et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

(2012) Jeffrey G. McDonald et al.   JOURNAL OF LIPID RESEARCH

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

(2012) Anna Meljon et al.   JOURNAL OF LIPID RESEARCH

Involvement of estrogen receptor β in maintenance of serotonergic neurons of the dorsal raphe

(2012) H Suzuki et al.   MOLECULAR PSYCHIATRY

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

(2012) Spyridon Theofilopoulos et al.   Nature Chemical Biology

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

(2011) Raku Shinkyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders of bile acid synthesis

(2011) Peter Theodore Clayton   JOURNAL OF INHERITED METABOLIC DISEASE

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

(2011) Gun-Young Heo et al.   JOURNAL OF LIPID RESEARCH

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

(2011) Libin Xu et al.   JOURNAL OF LIPID RESEARCH

Oxysterols direct B-cell migration through EBI2

(2011) Changlu Liu et al.   NATURE

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

(2011) Libin Xu et al.   NEUROBIOLOGY OF DISEASE

A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)

(2010) Yongjun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Estrogen receptor agonists and estrogen attenuate TNF- -induced apoptosis in VSC4.1 motoneurons

(2010) A. Das et al.   JOURNAL OF ENDOCRINOLOGY

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

(2010) Lihua Jin et al.   MOLECULAR ENDOCRINOLOGY

Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

(2010) P. de Medina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells

(2009) Paola Sacchetti et al.   Cell Stem Cell

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of oxysterols with membranes and proteins

(2009) Vesa M. Olkkonen et al.   MOLECULAR ASPECTS OF MEDICINE

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system

(2009) Yuqin Wang et al.   Molecular BioSystems

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

(2009) D. R. Bauman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators

(2008) Robert C. Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS

(2008) Akira Honda et al.   JOURNAL OF LIPID RESEARCH

The Effect of 24S-Hydroxycholesterol on Cholesterol Homeostasis in Neurons: Quantitative Changes to the Cortical Neuron Proteome

(2008) Yuqin Wang et al.   JOURNAL OF PROTEOME RESEARCH

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised

(2008) S GILL et al.   PROGRESS IN LIPID RESEARCH

27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator

(2007) Carolyn D. DuSell et al.   MOLECULAR ENDOCRINOLOGY