Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
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Title
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Authors
Keywords
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Journal
NATURE NEUROSCIENCE
Volume 24, Issue 1, Pages 47-60
Publisher
Springer Science and Business Media LLC
Online
2020-12-22
DOI
10.1038/s41593-020-00757-6
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- (2018) Daniel S. Reich et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2018) Evan D. Muse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2018) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination
- (2018) Zita Hubler et al. NATURE
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- (2017) Jo Mailleux et al. Multiple Sclerosis Journal
- Remyelination therapies: a new direction and challenge in multiple sclerosis
- (2017) Jason R. Plemel et al. NATURE REVIEWS DRUG DISCOVERY
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- Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
- (2008) C. F. Lucchinetti et al. BRAIN
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