Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

(2020) Maria Inês Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

(2020) Roberta Marisca et al.   NATURE NEUROSCIENCE

Motor learning promotes remyelination via new and surviving oligodendrocytes

(2020) Clara M. Bacmeister et al.   NATURE NEUROSCIENCE

Lesion stage-dependent causes for impaired remyelination in MS

(2020) Katharina Heß et al.   ACTA NEUROPATHOLOGICA

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

(2020) Robin J.M. Franklin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regionally diverse astrocyte subtypes and their heterogeneous response to EAE

(2020) Malte Borggrewe et al.   GLIA

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

(2020) Stefan A. Berghoff et al.   NATURE NEUROSCIENCE

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

(2020) Andrea Trevisiol et al.   PLOS BIOLOGY

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

MS progression is predominantly driven by age-related mechanisms – YES

(2019) Antonio Scalfari   Multiple Sclerosis Journal

Structural adaption of axons during de‐ and remyelination in the Cuprizone mouse model

(2019) Friederike Pfeiffer et al.   BRAIN PATHOLOGY

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

(2019) Rhonda R. Voskuhl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

The Axon-Myelin Unit in Development and Degenerative Disease

(2018) Ruth M. Stassart et al.   Frontiers in Neuroscience

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

(2017) Stefan A. Berghoff et al.   Nature Communications

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

(2017) Stefan A. Berghoff et al.   Acta Neuropathologica Communications

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development

(2014) Wenhui Huang et al.   GLIA

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism

(2012) Nutabi Camargo et al.   FASEB JOURNAL

Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth

(2012) U. Funfschilling et al.   JOURNAL OF NEUROSCIENCE

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

(2012) Gesine Saher et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Statin Therapy Inhibits Remyelination in the Central Nervous System

(2009) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1

(2009) Julia M. Edgar et al.   GLIA

Functional recovery of callosal axons following demyelination: a critical window

(2009) D.K. Crawford et al.   NEUROSCIENCE