Cholesterol determines the cytosolic entry and seeded aggregation of tau

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

(2021) Lijun Dai et al.   MOLECULAR NEUROBIOLOGY

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

(2021) Jingru Wang et al.   Nature Communications

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

(2021) Lauren V. C. Miller et al.   Acta Neuropathologica Communications

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

(2021) Andrés Guillén-Samander et al.   JOURNAL OF CELL BIOLOGY

Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization

(2021) Juan Carlos Polanco et al.   FEBS Journal

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Knockin’ on heaven’s door: Molecular mechanisms of neuronal tau uptake

(2020) Samantha De La‐Rocque et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors

(2019) Amulya Nidhi Shrivastava et al.   EMBO JOURNAL

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Cholesterol depletion by MβCD enhances cell membrane tension, its variations and reduces integrity

(2019) Arikta Biswas et al.   BIOPHYSICAL JOURNAL

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

(2019) Adrián Martín‐Segura et al.   AGING CELL

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

VPS35 regulates tau phosphorylation and neuropathology in tauopathy

(2019) Alana N. Vagnozzi et al.   MOLECULAR PSYCHIATRY

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

(2019) John J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

(2019) Yang Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Organotypic brain slice cultures to model neurodegenerative proteinopathies

(2019) C. L. Croft et al.   Molecular Neurodegeneration

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

(2019) Joseph Therriault et al.   JAMA Neurology

Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition

(2018) Bárbara Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism

(2018) Ying Liu et al.   JOURNAL OF LIPID RESEARCH

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Image-Based Profiling of Synaptic Connectivity in Primary Neuronal Cell Culture

(2018) Peter Verstraelen et al.   Frontiers in Neuroscience

Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector

(2018) Shi Cheng et al.   EXPERIMENTAL NEUROLOGY

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

(2018) Ingemar Björkhem et al.   Frontiers in Neurology

APOE ε2 is associated with increased tau pathology in primary tauopathy

(2018) Na Zhao et al.   Nature Communications

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

Galectin-8–mediated selective autophagy protects against seeded tau aggregation

(2017) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

(2017) William A. McEwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

(2017) Nadine Ait-Bouziad et al.   Nature Communications

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

(2017) Fabian Arenas et al.   Frontiers in Molecular Neuroscience

Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes

(2017) Matthias Pawlowski et al.   Stem Cell Reports

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Formation, release, and internalization of stable tau oligomers in cells

(2016) Susanne Wegmann et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons

(2016) Ernest Palomer et al.   Cell Reports

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

(2015) Junji Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Synaptogenesis of hippocampal neurons in primary cell culture

(2009) Andreas Grabrucker et al.   CELL AND TISSUE RESEARCH

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS