Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Published 2019 View Full Article

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Title
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
Authors
Keywords
Alzheimer’s disease, induced pluripotent stem cells, disease modeling, drug screening, lipids, cholesterol metabolism, cholesteryl esters, CYP46A1 Tau, amyloid beta, proteostasis
Journal
Cell Stem Cell
Volume 24, Issue 3, Pages 363-375.e9
Publisher
Elsevier BV
Online
2019-01-27
DOI
10.1016/j.stem.2018.12.013

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