APP Function and Lipids: A Bidirectional Link

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

(2018) Miki Igarashi et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Sphingomyelins are Associated with Cognitive Progression in Alzheimer's Disease

(2018) Michelle M. Mielke et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

(2018) Valery Filippov et al.   JOURNAL OF ALZHEIMERS DISEASE

A Review of the Major Vascular Risk Factors Related to Alzheimer's Disease

(2018) M. Cristina Polidori et al.   JOURNAL OF ALZHEIMERS DISEASE

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

(2018) Erik Hjorth et al.   JOURNAL OF ALZHEIMERS DISEASE

Midlife Vascular Risk Factors and the Risk of Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2018) Xiang-Fei Meng et al.   JOURNAL OF ALZHEIMERS DISEASE

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

(2016) Marcus O.W. Grimm et al.   Biochemistry and Cell Biology

Vitamin E: Curse or benefit in Alzheimer’s disease? A systematic investigation of the impact of α-, γ- and δ-tocopherol on Aβ generation and degradation in neuroblastoma cells

(2015) Marcus O. W. Grimm et al.   Journal of Nutrition Health & Aging

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

(2015) Marcus O.W. Grimm et al.   Neurodegenerative Diseases

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

(2015) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

The critical need for defining preclinical biomarkers in Alzheimer's disease

(2014) Massimo S. Fiandaca et al.   Alzheimers & Dementia

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

(2014) Marcus O.W. Grimm et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphatidylethanolamine plasmalogen enhances the inhibiting effect of phosphatidylethanolamine on  -secretase activity

(2014) T. Onodera et al.   JOURNAL OF BIOCHEMISTRY

Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

(2014) Ilker Karaca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglioside GD3 Is Required for Neurogenesis and Long-Term Maintenance of Neural Stem Cells in the Postnatal Mouse Brain

(2014) Jing Wang et al.   JOURNAL OF NEUROSCIENCE

Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Mice Lacking GD3 Synthase Display Morphological Abnormalities in the Sciatic Nerve and Neuronal Disturbances during Peripheral Nerve Regeneration

(2014) Victor Túlio Ribeiro-Resende et al.   PLoS One

Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors

(2014) Mitsuru Shinohara et al.   Frontiers in Aging Neuroscience

Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis

(2013) Hua Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

(2013) Hennariikka Koivisto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

(2013) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Dietary fat types and 4-year cognitive change in community-dwelling older women

(2012) Olivia I. Okereke et al.   ANNALS OF NEUROLOGY

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased concentration of the CSF Tau protein and its phosphorylated form in the late juvenile metachromatic leukodystrophy form: a case report

(2012) Joanna Tarasiuk et al.   JOURNAL OF NEURAL TRANSMISSION

Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain

(2012) Tomoko Kurata et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

(2012) Marcus O. W. Grimm et al.   PLoS One

Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease

(2012) Tatjana L. Rothhaar et al.   TheScientificWorldJOURNAL

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

(2012) David A. Hicks et al.   Frontiers in Physiology

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

Could dietary trans fatty acids induce movement disorders? Effects of exercise and its influence on Na+K+-ATPase and catalase activity in rat striatum

(2011) A.M. Teixeira et al.   BEHAVIOURAL BRAIN RESEARCH

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

(2011) Agnieszka Broniec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

(2011) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

(2011) Marcus O.W. Grimm et al.   JOURNAL OF CHROMATOGRAPHY A

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

(2011) Marcus O. W. Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP)

(2011) Marcus O.W. Grimm et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Structures, Biosynthesis, and Functions of Gangliosides-an Overview

(2011) Robert K. Yu et al.   Journal of Oleo Science

Monounsaturated, Trans, and Saturated Fatty Acids and Cognitive Decline in Women

(2011) Asghar Z. Naqvi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study

(2011) T. Matsuzaki et al.   NEUROLOGY

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Lipids in Alzheimer's disease: A century-old story

(2010) Paul Foley   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

(2010) Jack-Christophe Cossec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early-Onset Form (Type I) and Demyelination in Late-Onset Form (Type II)

(2010) Lars Svennerholm et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of cholesterol efflux by amyloid β secretion

(2010) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of Seal Oil and Tuna-Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

(2010) Neil J. Mann et al.   LIPIDS

The Pathogenic Implication of Abnormal Interaction Between Apolipoprotein E Isoforms, Amyloid-beta Peptides, and Sulfatides in Alzheimer’s Disease

(2010) Xianlin Han   MOLECULAR NEUROBIOLOGY

Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing

(2010) Xiaoguang Yang et al.   NEUROCHEMISTRY INTERNATIONAL

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

(2010) Greg Jicha   Clinical Interventions in Aging

Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging

(2009) Edeltraut Kröger et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

LIFE EXPECTANCY IN ALZHEIMER'S DISEASE (AD)

(2009) O. Zanetti et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

(2009) Benjamin Harris et al.   BRAIN RESEARCH

Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study

(2009) Yvonne Freund-Levi et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Dietary Fat Intake and Cognitive Decline in Women With Type 2 Diabetes

(2009) E. E. Devore et al.   DIABETES CARE

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

(2009) Elena Posse de Chaves et al.   FEBS LETTERS

Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry

(2009) Maï Panchal et al.   JOURNAL OF LIPID RESEARCH

Mechanism of docosahexaenoic acid-induced inhibition ofin vitroAβ1-42fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells

(2009) Shahdat Hossain et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects

(2009) Sylvia E. Perez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory

(2009) Kate S. Collison et al.   PHYSIOLOGY & BEHAVIOR

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulfatides facilitate apolipoprotein E-mediated amyloid- peptide clearance through an endocytotic pathway

(2008) Youchun Zeng et al.   JOURNAL OF NEUROCHEMISTRY

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

(2008) Alexandra Bernardo et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

(2008) Hua Cheng et al.   NEUROBIOLOGY OF AGING

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Cholesterol Potentiates β-Amyloid-Induced Toxicity in Human Neuroblastoma Cells: Involvement of Oxidative Stress

(2008) Patricia Ferrera et al.   NEUROCHEMICAL RESEARCH

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-β and tau pathologies in the 3xTg-AD model of Alzheimer's disease

(2008) A. Phivilay et al.   NEUROSCIENCE

Phosphatidyl ethanolamine with increased polyunsaturated fatty acids in compensation for plasmalogen defect in the Zellweger syndrome brain

(2008) Makiko Saitoh et al.   NEUROSCIENCE LETTERS

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

(2008) Chih-Chiang Chiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain

(2008) Lubica Cibickova et al.   STEROIDS

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE