Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

(2019) Elsa Sanchez-Lopez et al.   Cell Metabolism

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

(2019) Kie Itoh et al.   eLife

Myelin changes at the early stage of 5XFAD mice

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Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

(2018) Jiangyuan Gao et al.   Journal of Neuroinflammation

Association between Alzheimer’s disease pathogenesis and early demyelination and oligodendrocyte dysfunction

(2018) Xiao-Hong Sun et al.   Neural Regeneration Research

Long-term RF exposure on behavior and cerebral glucose metabolism in 5xFAD mice

(2018) Yeonghoon Son et al.   NEUROSCIENCE LETTERS

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Axon-Myelin Unit in Development and Degenerative Disease

(2018) Ruth M. Stassart et al.   Frontiers in Neuroscience

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2018) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging the evolution and pathophysiology of Alzheimer disease

(2018) William Jagust   NATURE REVIEWS NEUROSCIENCE

Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis

(2017) Fucheng Luo et al.   EXPERIMENTAL NEUROLOGY

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

(2017) Andrew T. McKenzie et al.   Molecular Neurodegeneration

Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1

(2017) Yi-Lin Yang et al.   Cell Death & Disease

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

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Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord

(2017) Tak-Ho Chu et al.   PLoS One

Microglia in Alzheimer’s disease: A multifaceted relationship

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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease

(2014) Xinhua Zhan et al.   Current Alzheimer Research

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

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Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

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Quantitative evaluation of MRI and histological characteristics of the 5xFAD Alzheimer mouse brain

(2013) N.G. Spencer et al.   NEUROIMAGE

NG2 cells, a new trail for Alzheimer’s disease mechanisms?

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Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies

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Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Mitochondrial division: molecular machinery and physiological functions

(2011) Yusuke Kageyama et al.   CURRENT OPINION IN CELL BIOLOGY

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

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Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

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Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

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Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

(2008) Maya K. Desai et al.   GLIA

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Regional white matter volume differences in nondemented aging and Alzheimer's disease

(2008) D SALAT et al.   NEUROIMAGE