Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

(2020) Yifeng Wang et al.   Nature Communications

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

(2020) Seung-Hwan Jung et al.   Redox Biology

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

(2019) Luca Laraia et al.   Nature Chemical Biology

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

Toward the role of cholesterol and cholesterol transfer protein in autophagosome biogenesis

(2019) Yao-Wen Wu et al.   Autophagy

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism

(2018) Keren E. Shapira et al.   MOLECULAR BIOLOGY OF THE CELL

Safety and efficacy of statin therapy

(2018) Bhavin B. Adhyaru et al.   Nature Reviews Cardiology

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

(2016) Jamal Bouitbir et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint

(2016) Kai Zheng et al.   Autophagy

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro

(2015) Guan-yu Liu et al.   ACTA PHARMACOLOGICA SINICA

The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis

(2015) Melanie L. Buckley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells

(2015) Urosh Vilimanovich et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death

(2015) Eran Schmukler et al.   Oncotarget

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

(2015) Hongyu Zhou et al.   Oncotarget

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

Dysfunctional autophagy in Alzheimer’s disease: pathogenic roles and therapeutic implications

(2014) Jun-Hua Liang et al.   Neuroscience Bulletin

Autophagy facilitates organelle clearance during differentiation of human erythroblasts

(2013) Virginie M.S. Betin et al.   Autophagy

Molecular Pathways: Sterols and Receptor Signaling in Cancer

(2013) L. Gabitova et al.   CLINICAL CANCER RESEARCH

The role of signalling in cellular cholesterol homeostasis

(2013) Winnie Luu et al.   IUBMB LIFE

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway

(2013) X-F Qi et al.   Cell Death & Disease

Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1

(2012) Hye-Kyung Na et al.   BIOCHEMICAL PHARMACOLOGY

Lipoproteins, cholesterol homeostasis and cardiac health

(2012) Tyler F. Daniels et al.   International Journal of Biological Sciences

Neuregulin Promotes Incomplete Autophagy of Prostate Cancer Cells That Is Independent of mTOR Pathway Inhibition

(2012) Eran Schmukler et al.   PLoS One

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Regulation of cholesterol homeostasis

(2011) Leigh Goedeke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern

(2011) S. Eisenberg et al.   MOLECULAR AND CELLULAR BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

(2010) Alessandro Fraldi et al.   EMBO JOURNAL

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY