Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Authors
Keywords
-
Journal
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-07
DOI
10.1007/s12035-020-02232-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Effect of statins on Parkinsonʼs disease
- (2019) Junqiang Yan et al. MEDICINE
- Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
- (2019) Rik van der Kant et al. Cell Stem Cell
- The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomics
- (2019) Arne De Roeck et al. ACTA NEUROPATHOLOGICA
- Association of statin use with Parkinson's disease: Dose–response relationship
- (2019) Su‐Min Jeong et al. MOVEMENT DISORDERS
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- Dopamine Burden Triggers Cholesterol Overload Following Disruption of Synaptogenesis in Minimal Hepatic Encephalopathy
- (2019) Weishan Zhuge et al. NEUROSCIENCE
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities
- (2019) Naomi P. Visanji et al. Translational Neurodegeneration
- Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study
- (2019) Yu An et al. Molecular Neurodegeneration
- Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
- (2018) Anna Rosenberg et al. Alzheimers & Dementia
- 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons
- (2018) Jared Schommer et al. BMC NEUROSCIENCE
- Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process
- (2018) Amin Karimi-Moghadam et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition
- (2018) Talia Zeppelin et al. PLoS Computational Biology
- Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease
- (2018) Laura Mateos et al. JOURNAL OF ALZHEIMERS DISEASE
- Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death
- (2018) Saleta Sierra et al. JOURNAL OF ALZHEIMERS DISEASE
- Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study
- (2018) Violetta Rozani et al. MOVEMENT DISORDERS
- Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
- (2018) Jenni Lehtisalo et al. Alzheimers & Dementia
- Impact of high cholesterol in a Parkinson’s disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation
- (2017) Ida Eriksson et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis
- (2017) Kaarin J. Anstey et al. JOURNAL OF ALZHEIMERS DISEASE
- 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
- (2017) Muhammad-Al-Mustafa Ismail et al. JOURNAL OF EXPERIMENTAL MEDICINE
- α-Synuclein Interacts with Lipoproteins in Plasma
- (2017) Fatemeh Nouri Emamzadeh et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Epidemiology of Parkinson’s disease
- (2017) Ole-Bjørn Tysnes et al. JOURNAL OF NEURAL TRANSMISSION
- α-Synuclein Regulates Neuronal Cholesterol Efflux
- (2017) Jen-Hsiang Hsiao et al. MOLECULES
- Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database
- (2017) Guodong Liu et al. MOVEMENT DISORDERS
- Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease
- (2017) Jennifer M. Walker et al. NEUROBIOLOGY OF DISEASE
- Protein misfolding in neurodegenerative diseases: implications and strategies
- (2017) Patrick Sweeney et al. Translational Neurodegeneration
- Leptin Reduces the Accumulation of Aβ and Phosphorylated Tau Induced by 27-Hydroxycholesterol in Rabbit Organotypic Slices
- (2017) Gurdeep Marwarha et al. JOURNAL OF ALZHEIMERS DISEASE
- Statin adherence and the risk of Parkinson's disease: A population-based cohort study
- (2017) Violetta Rozani et al. PLoS One
- Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats
- (2016) Aurélie Ledreux et al. BEHAVIOURAL BRAIN RESEARCH
- Statin use and risk of Parkinson’s disease: A meta-analysis
- (2016) Zhiguo Sheng et al. BEHAVIOURAL BRAIN RESEARCH
- Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease
- (2016) Fatemeh Nouri Emamzadeh et al. NEUROSCIENCE LETTERS
- High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice
- (2016) Peter Thériault et al. Oncotarget
- Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
- (2016) Gabriella Testa et al. Redox Biology
- Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis
- (2016) Shuang Bai et al. PLoS One
- 27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice
- (2015) Maura Heverin et al. BEHAVIOURAL BRAIN RESEARCH
- The impairment of cholesterol metabolism in Huntington disease
- (2015) Valerio Leoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?
- (2015) Gurdeep Marwarha et al. EXPERIMENTAL GERONTOLOGY
- Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes
- (2015) Andreas van Maarschalkerweerd et al. FEBS LETTERS
- A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
- (2015) Tiia Ngandu et al. LANCET
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- Early Statin Use and the Progression of Alzheimer Disease
- (2015) Feng-Cheng Lin et al. MEDICINE
- Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study
- (2015) Xuemei Huang et al. MOVEMENT DISORDERS
- Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients
- (2015) Christine R. Swanson et al. MOVEMENT DISORDERS
- Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies
- (2015) Keiko Nakamura et al. NEUROPATHOLOGY
- Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease
- (2015) Paola Gamba et al. Frontiers in Aging Neuroscience
- Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents
- (2014) M. G. Martin et al. EMBO Molecular Medicine
- Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
- (2014) Ahmed A. Saeed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin
- (2014) Jean E. Vance et al. JOURNAL OF LIPID RESEARCH
- Simvastatin prevents neuroinflammation by inhibiting N-methyl-D-aspartic acid receptor 1 in 6-hydroxydopamine-treated PC12 cells
- (2014) Junqiang Yan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Alpha synuclein is transported into and out of the brain by the blood–brain barrier
- (2014) Yu-Ting Sui et al. PEPTIDES
- Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1
- (2014) K Yamanaka et al. Cell Death & Disease
- Plasma apolipoprotein A1 as a biomarker for Parkinson disease
- (2013) Judy K. Qiang et al. ANNALS OF NEUROLOGY
- Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
- (2013) Julius Popp et al. BIOCHEMICAL PHARMACOLOGY
- Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1
- (2013) Jo V. Rushworth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic andCyp27a1−/−mice
- (2013) Zeina Ali et al. JOURNAL OF LIPID RESEARCH
- Mapping the Subcellular Distribution of -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis
- (2013) D. Boassa et al. JOURNAL OF NEUROSCIENCE
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice
- (2013) Jade de Oliveira et al. NEUROCHEMICAL RESEARCH
- Discontinuation of statin therapy associates with Parkinson disease: A population-based study
- (2013) Y.-C. Lee et al. NEUROLOGY
- Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease
- (2013) Ingemar Björkhem et al. NEUROSCIENCE LETTERS
- Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?
- (2013) Silvia Maioli et al. PLoS One
- Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients
- (2013) Qiang Wei et al. PLoS One
- Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis
- (2013) Bruce Reed et al. JAMA Neurology
- Cholesterol homeostasis: a key to prevent or slow down neurodegeneration
- (2013) Laura Anchisi et al. Frontiers in Physiology
- Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms
- (2012) Anil Kumar et al. BRAIN RESEARCH
- Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses
- (2012) Yun-Qi Xu et al. CNS Neuroscience & Therapeutics
- Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
- (2012) J. E. Vance Disease Models & Mechanisms
- Importance of cholesterol in dopamine transporter function
- (2012) Kymry T. Jones et al. JOURNAL OF NEUROCHEMISTRY
- Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease
- (2012) Julius Popp et al. JOURNAL OF NEUROCHEMISTRY
- Strong preferences of dopamine and l-dopa towards lipid head group: importance of lipid composition and implication for neurotransmitter metabolism
- (2012) Adam Orłowski et al. JOURNAL OF NEUROCHEMISTRY
- -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
- (2012) D. Scott et al. JOURNAL OF NEUROSCIENCE
- High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease
- (2012) C Pottier et al. MOLECULAR PSYCHIATRY
- Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease
- (2012) Adam S. Fleisher et al. NEUROBIOLOGY OF AGING
- A large study reveals no association between APOE and Parkinson's disease
- (2012) Monica Federoff et al. NEUROBIOLOGY OF DISEASE
- The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
- (2012) P. J. Barrett et al. SCIENCE
- The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain
- (2011) Jacques Fantini et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Plasma cholesterol and risk for late-onset Alzheimer’s disease
- (2011) Angel Cedazo-Mínguez et al. Expert Review of Neurotherapeutics
- Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis
- (2011) Catherine Marquer et al. FASEB JOURNAL
- Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism
- (2011) Laura Mateos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis
- (2011) Kazunori Yamanaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
- (2011) Marjan Shafaati et al. JOURNAL OF LIPID RESEARCH
- Unknown
- (2011) Noemi Fabelo et al. MOLECULAR MEDICINE
- Apolipoprotein E genotypes and the risk of Parkinson disease
- (2011) Jianjun Gao et al. NEUROBIOLOGY OF AGING
- Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses
- (2011) Junqiang Yan et al. PLoS One
- Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet
- (2010) Jill K. Morris et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease
- (2010) Madhav Thambisetty et al. ARCHIVES OF GENERAL PSYCHIATRY
- Membrane rafts in Alzheimer's disease beta-amyloid production
- (2010) Kulandaivelu S. Vetrivel et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
- (2010) H. H. Feldman et al. NEUROLOGY
- ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
- (2010) E. Y. Bryleva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Apolipoprotein E receptors in the nervous system
- (2009) Joachim Herz CURRENT OPINION IN LIPIDOLOGY
- Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies
- (2009) Andrew O. Koob et al. EXPERIMENTAL NEUROLOGY
- Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats
- (2009) Katja Nieweg et al. JOURNAL OF NEUROCHEMISTRY
- Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s Disease
- (2009) C. H. Williams-Gray et al. JOURNAL OF NEUROLOGY
- Oxysterols and neurodegenerative diseases
- (2009) Ingemar Björkhem et al. MOLECULAR ASPECTS OF MEDICINE
- Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
- (2009) Jaya RP Prasanthi et al. Molecular Neurodegeneration
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
- (2009) Jean-Charles Lambert et al. NATURE GENETICS
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse
- (2009) B. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Statins: Mechanisms of neuroprotection
- (2009) Peter J. van der Most et al. PROGRESS IN NEUROBIOLOGY
- Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress
- (2008) Chung-Yung J. Lee et al. ANTIOXIDANTS & REDOX SIGNALING
- Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Dietin vivoand by 27-Hydroxycholesterolin vitro
- (2008) Laura Mateos et al. BRAIN PATHOLOGY
- Plasma Lipid Levels in the Elderly Are Not Associated with the Risk of Mild Cognitive Impairment
- (2008) Christiane Reitz et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
- (2008) Denise M.O. Ramirez et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
- (2008) Woojin Scott Kim et al. JOURNAL OF NEUROCHEMISTRY
- High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
- (2008) Lakshmi Thirumangalakudi et al. JOURNAL OF NEUROCHEMISTRY
- Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells
- (2008) Jaya Prasanthi Rantham Prabhakara et al. JOURNAL OF NEUROCHEMISTRY
- Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease
- (2008) Pazit Bar-On et al. JOURNAL OF NEUROCHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Statin use and the risk of Parkinson disease
- (2008) A. D. Wahner et al. NEUROLOGY
- Total cholesterol and the risk of Parkinson disease
- (2008) G. Hu et al. NEUROLOGY
- Regulation of α-synuclein expression by liver X receptor ligands in vitro
- (2008) Danni Cheng et al. NEUROREPORT
- Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production
- (2007) Huaqi Xiong et al. NEUROBIOLOGY OF DISEASE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started