CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

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SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum

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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

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Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation

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ER membranes exhibit phase behavior at sites of organelle contact

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Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

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Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

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Cerebellar ataxia disease–associated Snx14 promotes lipid droplet growth at ER–droplet contacts

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NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

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ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

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Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

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SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20

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Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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Emerging Roles for the Lysosome in Lipid Metabolism

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

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Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

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Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

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Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

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Mdm1/Snx13 is a novel ER–endolysosomal interorganelle tethering protein

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Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

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Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

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Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

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An Essential Role of Hrs/Vps27 in Endosomal Cholesterol Trafficking

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Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

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Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

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Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

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Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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