Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes

Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

(2021) Bilge Ercan et al.   EMBO JOURNAL

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

(2020) J. H. Lorent et al.   Nature Chemical Biology

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

(2020) Michael E. Abrams et al.   Nature Microbiology

Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring

(2020) Maria Bohnert   DEVELOPMENTAL CELL

Aster proteins regulate the accessible cholesterol pool in the plasma membrane

(2020) Alessandra Ferrari et al.   MOLECULAR AND CELLULAR BIOLOGY

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

(2020) Michael N. Trinh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol

(2020) Shaobo Wang et al.   EMBO JOURNAL

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms

(2020) Xu Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Droplet Nucleation

(2020) Abdou Rachid Thiam et al.   TRENDS IN CELL BIOLOGY

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

(2019) Shreya Endapally et al.   CELL

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

(2019) Luca Laraia et al.   Nature Chemical Biology

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

(2019) Elina Ikonen et al.   DEVELOPMENTAL CELL

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

(2019) Chun-Yan Lim et al.   NATURE CELL BIOLOGY

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum

(2019) Kristen A. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

(2019) Tomoki Naito et al.   eLife

Defining raft domains in the plasma membrane

(2019) Akihiro Kusumi et al.   TRAFFIC

Exchange of water for sterol underlies sterol egress from a StARkin domain

(2019) George Khelashvili et al.   eLife

Mechanisms of cellular cholesterol compartmentalization: recent insights

(2018) Elina Ikonen   CURRENT OPINION IN CELL BIOLOGY

PI(4,5)P2controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

(2018) Mira Sohn et al.   JOURNAL OF CELL BIOLOGY

The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution

(2018) Tomoaki Sobajima et al.   JOURNAL OF CELL BIOLOGY

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

Transverse distribution of plasma membrane bilayer cholesterol: Picking sides

(2018) Theodore L. Steck et al.   TRAFFIC

Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation

(2018) Evan Quon et al.   PLOS BIOLOGY

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

(2018) Jaspreet Sandhu et al.   CELL

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

(2018) Cuiwen He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Rafts”: A nickname for putative transient nanodomains

(2018) Félix M. Goñi   CHEMISTRY AND PHYSICS OF LIPIDS

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

(2018) Huan Wang et al.   MOLECULAR CELL

A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C

(2017) Asami Makino et al.   FASEB JOURNAL

Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1

(2017) Mark Charman et al.   TRAFFIC

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

(2017) Rodney Elwood Infante et al.   eLife

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

CARTS biogenesis requires VAP–lipid transfer protein complexes functioning at the endoplasmic reticulum–Golgi interface

(2015) Yuichi Wakana et al.   MOLECULAR BIOLOGY OF THE CELL

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes

(2015) Joachim Moser von Filseck et al.   Nature Communications

Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling

(2014) Agata A. Bielska et al.   BIOCHEMISTRY

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

(2013) Kristiina Kanerva et al.   DEVELOPMENTAL CELL

Coordination between RAB GTPase and phosphoinositide regulation and functions

(2012) Steve Jean et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Osh Proteins Regulate Membrane Sterol Organization but Are Not Required for Sterol Movement Between the ER and PM

(2011) Alexander G. Georgiev et al.   TRAFFIC

Intracellular sterol dynamics

(2009) Bruno Mesmin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Requirement of Myosin Vb·Rab11a·Rab11-FIP2 Complex in Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface

(2009) Bei-Bei Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY