Diploid hepatocytes drive physiological liver renewal in adult humans

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

(2021) Lingjuan He et al.   SCIENCE

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

(2021) Yonglong Wei et al.   SCIENCE

Polyploidy in Cardiomyocytes

(2020) Wouter Derks et al.   CIRCULATION RESEARCH

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

(2020) Valentina C. Sladky et al.   DEVELOPMENTAL CELL

Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity but Develop Fewer Tumors Following Chronic Liver Injury

(2020) Yu-Hsuan Lin et al.   GASTROENTEROLOGY

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Polyploidy in liver development, homeostasis and disease

(2020) Romain Donne et al.   Nature Reviews Gastroenterology & Hepatology

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Polyploidy spectrum: a new marker in HCC classification

(2019) Myriam Bou-Nader et al.   GUT

Age Mosaicism across Multiple Scales in Adult Tissues

(2019) Rafael Arrojo e Drigo et al.   Cell Metabolism

Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration

(2019) Feng Chen et al.   Cell Stem Cell

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

(2019) Tianliang Sun et al.   Cell Stem Cell

In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration

(2019) Tomonori Matsumoto et al.   Cell Stem Cell

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

(2018) Xing Deng et al.   Cell Stem Cell

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

(2018) Shuyuan Zhang et al.   DEVELOPMENTAL CELL

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

(2018) Hagen B. Huttner et al.   EBioMedicine

The polyploid state restricts hepatocyte proliferation and liver regeneration

(2018) Patrick D Wilkinson et al.   HEPATOLOGY

Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration

(2017) Yue Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks

(2017) Fabian Fröhlich et al.   PLoS Computational Biology

Analysis of CFSE time-series data using division-, age- and label-structured population models

(2016) Sabrina Hross et al.   BIOINFORMATICS

Dynamic zonation of liver polyploidy

(2016) Sivan Tanami et al.   CELL AND TISSUE RESEARCH

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC

(2016) Aki Vehtari et al.   STATISTICS AND COMPUTING

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Aging and liver disease

(2015) In Hee Kim et al.   CURRENT OPINION IN GASTROENTEROLOGY

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

Small sample Accelerator Mass Spectrometry for biomedical applications

(2015) M. Salehpour et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

(2015) Hernán Morales-Navarrete et al.   eLife

A new model to simulate and analyze proliferating cell populations in BrdU labeling experiments

(2014) Daniella Schittler et al.   BMC Systems Biology

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Reversal of hepatocyte senescence after continuousin vivocell proliferation

(2014) Min-Jun Wang et al.   HEPATOLOGY

The age and genomic integrity of neurons after cortical stroke in humans

(2014) Hagen B Huttner et al.   NATURE NEUROSCIENCE

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Hepatocellular Proliferation Correlates with Inflammatory Cell and Cytokine Changes in a Murine Model of Nonalchoholic Fatty Liver Disease

(2013) Michael N. VanSaun et al.   PLoS One

emcee: The MCMC Hammer

(2013) Daniel Foreman-Mackey et al.   PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF THE PACIFIC

Bomb-pulse 14C analysis combined with 13C and 15N measurements in blood serum from residents of Malmö, Sweden

(2013) Elisavet Georgiadou et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

The Age of Olfactory Bulb Neurons in Humans

(2012) Olaf Bergmann et al.   NEURON

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

A mathematical model for the interpretation of nuclear bomb test derived 14C incorporation in biological systems

(2009) Samuel Bernard et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE