Genistein: a promising modulator of apoptosis and survival signaling in cancer

Chemopreventive mechanisms of amentoflavone: recent trends and advancements

(2023) Hardeep Singh Tuli et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Design, synthesis and anti-cancer evaluation of genistein-1,3,5-triazine derivatives

(2023) Jing-Pei Zou et al.   TETRAHEDRON

Genistein: A novel inhibitor of IL-6/IL-6R interface of the Interleukin-6–mediated STAT3 dependent pathway of carcinogenesis

(2022) Saurabh Sharma et al.   JOURNAL OF MOLECULAR STRUCTURE

Genistein—Opportunities Related to an Interesting Molecule of Natural Origin

(2022) Ewa Garbiec et al.   MOLECULES

Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates

(2022) Ahmed M. Salem et al.   RADIATION RESEARCH

Genistein, a Potential Phytochemical against Breast Cancer Treatment-Insight into the Molecular Mechanisms

(2022) Md Sohel et al.   Processes

Therapeutic potentials of genistein: New insights and perspectives

(2022) Sumbal Rasheed et al.   JOURNAL OF FOOD BIOCHEMISTRY

Impact of highly phospholipid-containing lipid nanocarriers on oral bioavailability and pharmacodynamics performance of genistein

(2022) Mohammed Elmowafy et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

High Concentrations of Genistein Decrease Cell Viability Depending on Oxidative Stress and Inflammation in Colon Cancer Cell Lines

(2022) Marina Alorda-Clara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis

(2022) Kanchana Suksri et al.   Scientific Reports

Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells

(2022) Chutipa Chiawpanit et al.   Biology-Basel

Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring

(2022) Roger W. L. Godschalk et al.   Frontiers in Nutrition

Evaluation of the Effects of Genistein In Vitro as a Chemopreventive Agent for Colorectal Cancer—Strategy to Improve Its Efficiency When Administered Orally

(2022) Juan Pablo Rendón et al.   MOLECULES

Genistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells

(2022) Liujia Chan et al.   PHARMACEUTICAL BIOLOGY

Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer

(2022) Arjun Patra et al.   Artificial Cells Nanomedicine and Biotechnology

Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers

(2022) Artur A. Serebrenik et al.   Clinical Pharmacology in Drug Development

Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women: a 2-year randomized double-blind placebo controlled clinical trial

(2022) Lee-Jane W. Lu et al.   Clinical Nutrition ESPEN

Metal-coordinated nanodrugs based on natural products for cancer theranostics

(2022) Shuang Liu et al.   CHEMICAL ENGINEERING JOURNAL

PEGylation of genistein-loaded bovine serum albumin nanoparticles and its effect on in vitro cell viability and genotoxicity properties

(2022) Joana B. Ferrado et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Transmucosal Solid Lipid Nanoparticles to Improve Genistein Absorption via Intestinal Lymphatic Transport

(2021) Antonella Obinu et al.   Pharmaceutics

Physiologically Active Molecules and Functional Properties of Soybeans in Human Health—A Current Perspective

(2021) Il-Sup Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of genistein-loaded gold nanoparticles and their antitumor potential against prostate cancer cell lines

(2021) Vesna V. Vodnik et al.   Materials Science & Engineering C-Materials for Biological Applications

Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study

(2021) Maarten C. Bosland et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hepcidin Upregulation in Lung Cancer: A Potential Therapeutic Target Associated With Immune Infiltration

(2021) Yumei Fan et al.   Frontiers in Immunology

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies

(2021) Sachelly Julián-Serrano et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma

(2021) Chakrabhavi Dhananjaya Mohan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Genistein loaded in self-assembled bovine serum albumin nanovehicles and their effects on mouse mammary adenocarcinoma cells

(2021) Joana B. Ferrado et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Pharmacokinetics of genistein distribution in blood and retinas of diabetic and non-diabetic rats

(2021) T. Hakami et al.   Drug Metabolism and Pharmacokinetics

Synthesis and Bio-evaluation of 2-Alkyl Substituted Fluorinated Genistein Analogues Against Breast Cancer

(2021) Yingl Zhu et al.   Medicinal Chemistry

Genistein: Dual Role in Women’s Health

(2021) Linda Yu et al.   Nutrients

Combined Beneficial Effect of Genistein and Atorvastatin on Adipogenesis in 3T3-L1 Adipocytes

(2021) Dahae Lee et al.   Biomolecules

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

(2021) Il-Sup Kim   Antioxidants

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

(2021) Javad Sharifi-Rad et al.   Frontiers in Molecular Biosciences

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

(2021) Liyan Yang et al.   Biomedicines

Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells

(2021) Ayyiliath M Sajith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genistein protects epilepsy-induced brain injury through regulating the JAK2/STAT3 and Keap1/Nrf2 signaling pathways in the developing rats

(2021) Qing-peng Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway

(2021) Loukik Arora et al.   Cancers

3-Formylchromone Counteracts STAT3 Signaling Pathway by Elevating SHP-2 Expression in Hepatocellular Carcinoma

(2021) Chakrabhavi Dhananjaya Mohan et al.   Biology-Basel

The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein

(2020) Cord Naujokat et al.   CURRENT MEDICINAL CHEMISTRY

Genistein inhibited the proliferation of kidney cancer cells via CDKN2a hypomethylation: role of abnormal apoptosis

(2020) Zhengguo Ji et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Genistein Enhances Radiosensitivity of Human Hepatocellular Carcinoma Cells by Inducing G2/M Arrest and Apoptosis

(2020) Hongli Yan et al.   RADIATION RESEARCH

Beneficial effects of genistein in suppression of proliferation, inhibition of metastasis, and induction of apoptosis in PC3 prostate cancer cells

(2020) Gholamreza Shafiee et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways

(2020) Jing Gao et al.   Aging-US

The potential health benefits of the isoflavone glycoside genistin

(2020) Anowarul Islam et al.   ARCHIVES OF PHARMACAL RESEARCH

Fabrication of nanostructured mesoporous starch encapsulating soy-derived phytoestrogen (genistein) by well-tuned solvent exchange method

(2020) Marjan Soleimanpour et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

(2020) Chakrabhavi Dhananjaya Mohan et al.   SEMINARS IN CANCER BIOLOGY

Genistein inhibits migration and invasion of cervical cancer HeLa cells by regulating FAK-paxillin and MAPK signaling pathways

(2020) Chunlin Chen et al.   Taiwanese Journal of Obstetrics & Gynecology

Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway

(2020) Jong Hyun Lee et al.   BIOCHIMIE

Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis

(2020) Pei-Ling Hsieh et al.   Nutrients

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

(2020) Jong Hyun Lee et al.   Journal of Advanced Research

Genistein nanoformulation promotes selective apoptosis in Oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway

(2020) Atul Dev et al.   PHYTOMEDICINE

Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer

(2020) Vikas H. Malojirao et al.   Biomedicines

Genistein enhances the effects of L‐asparaginase on inducing cell apoptosis in human leukemia cancer HL ‐60 cells

(2020) Yin‐Chen Hsiao et al.   ENVIRONMENTAL TOXICOLOGY

Soy protein supplementation in men following radical prostatectomy: a 2-year randomized, placebo-controlled clinical trial

(2020) Maarten C Bosland et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

(2019) Sang R. Lee et al.   BMC CANCER

Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation

(2019) Jingyan Tian et al.   CANCER LETTERS

Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo

(2019) Yin-Chen Hsiao et al.   ENVIRONMENTAL TOXICOLOGY

Inhalable Dual-Targeted Hybrid Lipid Nanocore–Protein Shell Composites for Combined Delivery of Genistein and All-Trans Retinoic Acid to Lung Cancer Cells

(2019) Nayra M. Kamel et al.   ACS Biomaterials-Science & Engineering

Encapsulation of Nutraceutical Ingredients in Liposomes and Their Potential for Cancer Treatment

(2019) Sayantani Dutta et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Isoflavones

(2019) Ludmila Křížová et al.   MOLECULES

Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases

(2019) Min Yang et al.   MOLECULES

Potential of Zerumbone as an Anti-Cancer Agent

(2019) Sosmitha Girisa et al.   MOLECULES

Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms

(2019) Lon S. Schneider et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome

(2019) Michael R Landauer et al.   JOURNAL OF RADIATION RESEARCH

Genistein combined with FOLFOX or FOLFOX–Bevacizumab for the treatment of metastatic colorectal cancer: phase I/II pilot study

(2019) Sofya Pintova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

(2019) Abu Hazafa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling

(2019) Qi Zhang et al.   PHYTOTHERAPY RESEARCH

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates

(2019) Koita Sacko et al.   Nanomaterials

Clinical candidate and genistein analogue AXP107‐11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein‐coupled estrogen receptor signaling

(2019) Fahmi Mesmar et al.   Cancer Medicine

Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway

(2019) Wen-Xiang Cheng et al.   Journal of Orthopaedic Translation

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

(2019) Jong Hyun Lee et al.   Biomolecules

Isoflavone Supplements for Menopausal Women: A Systematic Review

(2019) Li-Ru Chen et al.   Nutrients

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

(2019) Park et al.   Antioxidants

Enterohepatic Circulation and Pharmacokinetics of Genistin and Genistein in Rats

(2019) Ya-Yu Yang et al.   ACS Omega

In-vitro Detection of Phytopathogenic Fungal Cell Wall by Polyclonal Sera Raised Against Trimethyl Chitosan Nanoparticles

(2019) Hemant Joshi et al.   International Journal of Nanomedicine

Genistein potentiates Centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis

(2019) Shweta Kaushik et al.   LIFE SCIENCES

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

(2019) Hardeep Singh Tuli et al.   Frontiers in Pharmacology

The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells

(2019) Jong Hyun Lee et al.   Biomolecules

MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells

(2018) Chang-hong Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Preparation, characterization, and pharmacokinetics study of a novel genistein-loaded mixed micelles system

(2018) Hongxue Shen et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation

(2018) Bidisha Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G 0 /G 1 cell cycle arrest and regulation of STAT3 signalling pathway

(2018) Yi-liang Bi et al.   PHYTOMEDICINE

Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage

(2018) Guanyi Wang et al.   Biomaterials Science

The anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells

(2018) Hua Jiang et al.   OncoTargets and Therapy

Formulation and characterization of Genistein-loaded nanostructured lipid carriers: Pharmacokinetic, Biodistribution and In vitro cytotoxicity studies

(2018) Pooja MIttal et al.   Current Drug Delivery

Effects of Isolated Isoflavones Intake on Health

(2017) Antonella Smeriglio et al.   CURRENT MEDICINAL CHEMISTRY

Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

(2016) Yang Yang et al.   Oncology Letters

Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions

(2016) C. P. Baburajeev et al.   RSC Advances

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy

(2015) Xiaoyun Dai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Genistein enhances TRAIL-induced cancer cell death via inactivation of autophagic flux

(2015) UDDIN MD. NAZIM et al.   ONCOLOGY REPORTS

Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells

(2015) Jian Qin et al.   PHARMACEUTICAL BIOLOGY

Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells

(2015) Jun Chen et al.   Food & Function

Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure

(2015) Chang-Deng Hu et al.   Frontiers in Oncology

Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia

(2014) Jin-Woo Jeong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic cytotoxic effect of genistein and doxorubicin on drug-resistant human breast cancer MCF-7/Adr cells

(2014) JIA-PENG XUE et al.   ONCOLOGY REPORTS

Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway

(2014) Yi Luo et al.   TUMOR BIOLOGY

Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor ΚB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells

(2014) Jinchao Li et al.   Drug Design Development and Therapy

Deregulation of PI3K/Akt/mTOR Signaling Pathways by Isoflavones and its Implication in Cancer Treatment

(2013) Aamir Ahmad et al.   Anti-Cancer Agents in Medicinal Chemistry

The small molecule, genistein, increases hepcidin expression in human hepatocytes

(2013) Aileen W. Zhen et al.   HEPATOLOGY

The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells

(2013) Bidur Parajuli et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Genistein Enhances the Radiosensitivity of Breast Cancer Cells via G2/M Cell Cycle Arrest and Apoptosis

(2013) Xiongxiong Liu et al.   MOLECULES

Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2

(2013) Masakatsu Oishi et al.   PLoS One

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

(2011) Wentao Qi et al.   BMC CANCER

Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage

(2009) Cheng-Yun Jin et al.   ANTI-CANCER DRUGS

Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

(2009) Gaoliang Ouyang et al.   CELL BIOLOGY INTERNATIONAL

Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells

(2009) Cheng-Yun Jin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis

(2009) Markus David Siegelin et al.   NEUROSCIENCE LETTERS

Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

(2008) Ewelina Szliszka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genistein down-regulates the constitutive activation of nuclear factor-κB in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

(2008) Hui He et al.   PHYTOTHERAPY RESEARCH

Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway

(2008) Zhong Li et al.   TOXICOLOGY IN VITRO