Article
Biophysics
Joana B. Ferrado, Adrian A. Perez, Malen Menegon, Victoria A. Vaillard, Fatima Gasser, Maria E. Baravalle, Hugo H. Ortega, Santiago E. Vaillard, Liliana G. Santiago
Summary: In this study, self-assembled bovine serum albumin nanoparticles loaded with genistein were PEGylated to avoid possible immunogenic reactions and rapid clearance from the bloodstream. The PEGylation process increased the particle size of the nanoparticles and improved their biological properties, reducing cytotoxicity and genotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Tijo Cherian, Debasis Maity, Ramasamy T. Rajendra Kumar, Govindasamy Balasubramani, Chinnasamy Ragavendran, Suneelkumar Yalla, Raju Mohanraju, Willie J. G. M. Peijnenburg
Summary: Green chemistry has made significant advancements in the production of environmentally friendly nanoparticles using biological agents. This study introduces the potential of the marine bacterium Lysinibacillus odysseyi PBCW2 for producing gold nanoparticles with antioxidant, antibacterial, and dye-degrading properties.
Article
Chemistry, Multidisciplinary
Andrea Jess Josiah, Sreejarani K. Pillai, Werner Cordier, Margo Nell, Danielle Twilley, Namrita Lall, Suprakas Sinha Ray
Summary: This study investigated the green synthesis of gold and silver nanoparticles using CBD and explored their formation conditions and characteristics. The potential cytotoxicity of CBD-capped nanoparticles was found to be minimal at the cellular level.
Article
Biochemistry & Molecular Biology
Silvia Soares, Isabel Faria, Fatima Aires, Armanda Monteiro, Gabriela Pinto, Maria Goreti Sales, Miguel A. Correa-Duarte, Susana G. Guerreiro, Ruben Fernandes
Summary: More than 50% of prostate cancer patients are treated with radiotherapy. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome the limitations of radiotherapy. This study assessed the biological interaction of different morphologies of AuNPs with ionizing radiation (IR) in prostate cancer cells. The results showed that AuNPs combined with IR decreased cell viability and increased apoptosis, suggesting that AuNPs could improve the efficacy of radiotherapy in prostate cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Sonia, Komal, Shrikant Kukreti, Mahima Kaushik
Summary: Gold nanoclusters with core size below 2 nm exhibit unique physical and chemical properties, synthesized with the assistance of templates or ligands for stability and high quantum yield, enabling diverse applications across interdisciplinary fields.
Review
Chemistry, Multidisciplinary
Ali Shakeri-Zadeh, Hajar Zareyi, Roghayeh Sheervalilou, Sophie Laurent, Habib Ghaznavi, Hadi Samadian
Summary: Microbubbles have been extensively studied in biomedicine, with gold nanoparticles being used with lasers to decrease energy threshold. Well-confined bubbles can have unique mechanical and optical roles, making them suitable for cancer imaging and aiding in targeted cancer therapy. However, clinical translation of this technique may be limited to easily accessible tumors, with challenges still needing to be addressed.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Muhammad Asam Raza, Umme Farwa, Muhammad Waseem Mumtaz, Javeria Kainat, Areej Sabir, Abdullah G. Al-Sehemi
Summary: Green nanotechnology is an eco-friendly method for biosynthesis of metallic nanoparticles, which is cost-effective, environmentally friendly, and safe. The use of medicinal plants to treat diseases has been proven effective by the World Health Organization. This review highlights the significance of green synthesis of gold and silver nanoparticles and emphasizes their potential as anticancer and antidiabetic agents.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2023)
Article
Chemistry, Analytical
Ying He, Fangxin Hu, Jinwen Zhao, Guomin Yang, Yuanyuan Zhang, Shihong Chen, Ruo Yuan
Summary: A novel dual-signal combined nanoprobe with two different types of nanoparticles as ECL probes and hydrogen peroxide as a bifunctional moderator was designed for enzyme sensing analysis. In the presence of organophosphorus compounds, enzyme activity was inhibited, leading to changes in ECL signals. This integrated system provides a new pathway for ratiometric ECL systems involving enzyme catalytic amplification.
ANALYTICAL CHEMISTRY
(2021)
Review
Green & Sustainable Science & Technology
Altaf Hussain, Muhammad Nazim Lakhan, Abdul Hanan, Irfan Ali Soomro, Mukhtiar Ahmed, Faiza Bibi, Irum Zehra
Summary: Nanoparticles have gained significant attention in various fields, and green synthesis using living organisms as reducing and stabilizing agents is preferred due to reduced environmental toxicity. Green synthesized selenium nanoparticles have great significance in various applications. This review provides an overview of synthesis approaches, morphology, and factors affecting production, as well as prospects for the future.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Chemistry, Multidisciplinary
Zili Huang, Xiaobo Xie, Bei Xu, Rui Liu, Jianyu Hu, Yi Lv
Summary: In this study, a standard-free single magnetic bead nanoplatform using metal nanoparticles was proposed for prostate disease diagnosis. The inaccuracy of detection was reduced by evaluating metal intensities. The proportion of free PSA in total PSA was successfully evaluated using the Pt/Au intensity ratio, showing better differentiation between different disease states.
Review
Nanoscience & Nanotechnology
Anqi Zhang, Lei Gao
Summary: Radiotherapy is an important method for treating malignant tumors. Enhancing its therapeutic gain ratio through physical techniques is the current direction of radiotherapy. The combination of hyperthermia and radiotherapy can improve the radiosensitivity of tumor cells and has significant clinical value. Nanomaterials have attracted widespread attention in tumor hyperthermia research and show great potential. This article summarizes the sensitizing mechanisms and effects of gold nanotechnology and provides an overview of the advancements of other nanoparticles in radiation therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Materials Science, Biomaterials
Andreea Campu, Ilinca Muresan, Monica Potara, Diana Raluca Lazar, Florin-Leontin Lazar, Simona Cainap, Dan Mircea Olinic, Dana Maniu, Simion Astilean, Monica Focsan
Summary: This study develops a microfluidic plasmonic chip that can efficiently and accurately detect the cardiac troponin I biomarker via three complementary detection techniques. The study also provides a better understanding of the thermoplasmonic biosensing mechanism using gold nanoparticles' photothermal properties.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Weichong Zhao, Lihui Wang, Hua Chen, Lei Qi, Ruihong Yang, Tao Ouyang, Lei Ning
Summary: In this study, gold nanoparticles were successfully synthesized using the aqueous extract of Alhagi maurorum leaf, and their properties were characterized. The synthesized nanoparticles exhibited cytotoxicity and anti-cancer properties on prostate carcinoma cells. Additionally, the nanoparticles showed antioxidant activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Adrianne M. M. Brito, Vitor Oliveira, Marcelo Y. Icimoto, Iseli L. Nantes-Cardoso
Summary: This study focuses on improving the stability and specific activity of Bromelain by immobilizing it on gold nanoparticles, termed NanoBro. The NanoBro showed enhanced thermal stability and increased cysteine protease activity, leading to a broader range of applications and improved performance. The structural changes and characteristics of NanoBro were analyzed using various techniques, highlighting the potential benefits of this immobilization approach.
Article
Plant Sciences
Petra Lovecka, Anna Macurkova, Kamil Zaruba, Tomas Hubacek, Jakub Siegel, Olga Valentova
Summary: The study revealed that AgNPs and AuNPs have damaging effects on the DNA of tobacco plants, with significant DNA damage observed at a concentration of 30 mg.kg(-1) of AgNPs but no significant effect from AuNPs. The silver content in leaves at a concentration of 30 mg.kg(-1) of AgNPs was determined to be approximately 2.720 μg.g(-1). Long-term effects were found to be less harmful, possibly due to the plant's restoration capability.
Article
Materials Science, Textiles
Ana Krkobabic, Darka Markovic, Aleksandar Kovacevic, Vanja Tadic, Marija Radoicic, Tatjana Barudzija, Tatjana Ilic-Tomic, Maja Radetic
Summary: The aim of this study was to develop antimicrobial nanocomposite textile material using bearberry leaves extract as a green reducing agent to synthesize copper-based nanostructures on oxidized cotton fabric, which showed excellent antibacterial activity.
FIBERS AND POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
J. Potocnik, N. Bozinovic, M. Novakovic, T. Barudzija, M. Nenadovic, M. Popovic
Summary: This study investigates the impact of thickness on the structural and optical properties of copper helical nanostructures. It was found that the deposited structures are porous with nanometer-sized crystallites oriented along (111) planes, and the diameter of the helices increases with thickness. Optical analysis revealed that the dielectric function of copper structures is greatly influenced by film thickness, with the surface plasmon resonance peak shifting as the thickness increases.
Article
Engineering, Electrical & Electronic
Danijela Danilovic, Dusan K. Bozanic, Gustavo A. Garcia, Laurent Nahon, Una Stamenovic, Vesna V. Vodnik, Vladimir Djokovic
Summary: The angle-resolved photoelectron spectroscopy of isolated silver sulfide nanoparticles was conducted using velocity map imaging technique. The results show the maximum energy of the valance band and the minimum energy of the conduction band of the nanoparticles, and the onset of inelastic scattering at around 1 eV.
OPTICAL AND QUANTUM ELECTRONICS
(2022)
Article
Chemistry, Physical
Jadranka Milikic, Andres Tapia, Una Stamenovic, Vesna Vodnik, Mojca Otonicar, Sreco Skapin, Diogo M. F. Santos, Biljana Sljukic
Summary: Gold polypyrrole (AuPPy) and copper polypyrrole (CuPPy) nanocomposites were synthesized and evaluated as electrocatalysts for borohydride oxidation reaction. The apparent activation energies for BOR of AuPPy and CuPPy electrocatalysts were 16 and 22 kJ mol-1, respectively. Moreover, when applied in a direct borohydride-peroxide fuel cell, both AuPPy and CuPPy exhibited high open circuit voltage and peak power density.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Oncology
Sisca Ucche, Satoru Yokoyama, Marija Mojic, Kohei Oki, Chikako Ohshima, Haruka Tsuihiji, Ichiro Takasaki, Hideaki Tahara, Yoshihiro Hayakawa
Summary: This study investigates how tumor cells escape from the immune response by analyzing immune-escape variants of melanoma cells. The researchers identify GSTA4 as a critical molecule in this process and find that immune escape melanoma variants acquire greater metastatic ability through a GSTA4-dependent mechanism.
MOLECULAR CANCER RESEARCH
(2023)
Article
Chemistry, Medicinal
Liridona Useini, Marija Mojic, Markus Laube, Peter Loennecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Jens Pietzsch, Evamarie Hey-Hawkins
Summary: Fenoprofen is a common NSAID used to treat rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis, and gout. It inhibits the synthesis of prostaglandins by blocking both COX-1 and COX-2 isoforms. Modifications using carborane clusters showed stronger antitumor potential compared to aryl-based compounds.
Article
Biochemistry & Molecular Biology
Svetlana Trifunovic, Branka Sosic Jurjevic, Natasa Ristic, Natasa Nestorovic, Branko Filipovic, Ivana Stevanovic, Vesna Begovic-Kupresanin, Milica Manojlovic-Stojanoski
Summary: The placenta plays an important role in providing a suitable environment for fetal growth. This study found that there are sex differences in the placenta's morphological features and antioxidant status after exposure to dexamethasone (Dx). Female placentas showed a greater decrease in volume and antioxidant enzyme activities, and an increase in lipid peroxides and nitric oxide concentration compared to male placentas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Nikolina Nikolic, Jelena Spasojevic, Aleksandra Radosavljevic, Milica Milosevic, Tanja Barudzija, Lazar Rakocevic, Zorica Kacarevic-Popovic
Summary: A series of silver nanoparticle-polymer hydrogel nanocomposites were synthesized to examine the matrix's impact on properties of silver nanocrystals important for strain engineering in functional materials. Various characterization techniques were used to analyze the structural parameters and cluster size effects of the nanocomposites. The nanocomposites also showed significant antibacterial potential.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Milica Markelic, Marija Mojic, Dijana Bovan, Sanja Jelaca, Zorana Jovic, Milica Puric, Djuro Koruga, Sanja Mijatovic, Danijela Maksimovic-Ivanic
Summary: Our study demonstrated that treatment of melanoma cells with hyperpolarized light (HPL) and hyper-harmonized hydroxylated fullerene water complex (3HFWC) reduced cell viability and induced senescence and reprogramming towards normal phenotype. We investigated whether these effects persisted in vivo in a mouse melanoma model with combined treatment of HPL irradiation and 3HFWC. The results showed potent antitumor effects, including growth arrest, senescent phenotype, melanocytic differentiation, and activation of antitumor immune response.
Article
Materials Science, Multidisciplinary
Dijana Masojevic, Una Stamenovic, Mojca Otonicar, Sladana Davidovic, Sreco Skapin, Tanja Barudzijaa, Vesna Vodnik
Summary: This study presents a novel antibacterial agent based on the combination of copper nanoparticles (CuNPs) and poly-pyrrole (PPy). The Cu/PPy nanocomposite, characterized by spherical CuNPs around 25 nm in diameter uniformly dispersed throughout a granular PPy matrix, was synthesized using a straightforward in situ polymerization method in water. The antibacterial activity of Cu/PPy against E. coli and S. aureus was determined, demonstrating the synergistic engagement of CuNPs and PPy. Low concentrations of Cu/PPy, such as 2 ppm with 9.45 wt% Cu content, showed significant antibacterial efficacy, indicating its potential as a safe and environmentally acceptable antibacterial agent.
Review
Biology
Vladimir Z. Ajdzanovic, Branka T. Sosic-Jurjevic, Jovan T. Ranin, Branko R. Filipovic
Summary: In his Theory of relativity, Einstein determined that time is relative to the observer's reference frame. This concept is also applicable to the brain operating at different frequencies, resulting in time dilation. The perception of time flow and aging are interconnected. In this article, we introduce the concept of physical relativity into the context of the mind and thought, particularly focusing on the changed perception of time flow with aging. We also discuss the impact of mental processing impairment on the relativity of time caused by aging and suggest that adjusting its perception requires rest, mental hygiene, and physical activity.
Article
Materials Science, Ceramics
Tijana Stamenkovic, Ivana Dinic, Marina Vukovic, Nadezda Radmilovic, Tanja Barudzija, Milos Tomic, Lidija Mancic, Vesna Lojpur
Summary: In this study, strontium-gadolinium-oxide (SrGd2O4) samples doped with different Yb3+ concentrations and co-doped with Bi3+ were prepared. The inclusion of Bi3+ improved the photoluminescent properties, but decreased the photocatalytic efficiency of the samples.
CERAMICS INTERNATIONAL
(2023)
Review
Public, Environmental & Occupational Health
Vladimir Ajdzanovic, Marko Miler, Branka Sosic-Jurjevic, Branko Filipovic
Summary: Prostate health is related to the frequency of ejaculation and prostate drainage. The proximity of the rectum and prostate enables lower bowel distention to compress the prostate's lateral side to facilitate drainage, which might lower cancer risk. Dietary content and gastrointestinal activity can improve prostate drainage.
JOURNAL OF MENS HEALTH
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)