Genistein: a promising modulator of apoptosis and survival signaling in cancer

Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely evaluated for its anti-cancer potential. Several studies have established the potential for its usage in the management of breast, lung, and prostate cancers, and its usage has significantly evolved from early applications in traditional systems of medicine. This review offers an insight into its current status of usage, the chemistry, and pharmacokinetics of the molecule, an exploration of its apoptotic mechanisms in cancer management, and opportunities for synergism to improve therapeutic outcomes. In addition to this, the authors have presented an overview of recent clinical trials, to offer an understanding of contemporary studies and explore prospects for a greater number of focused trials, moving forward. Advancements in the application of nanotechnology as a strategy to improve safety and efficacy have also been highlighted, with a brief discussion of results from safety and toxicology studies.

Automated summary

Genistein, a commonly occurring isoflavone, has gained popularity for its diverse pharmacological benefits, including improved bone health, reduced postmenopausal complications, and anti-cancer potential. This review provides insights into its usage, chemistry, pharmacokinetics, apoptotic mechanisms in cancer management, opportunities for synergism, and recent clinical trials. Additionally, advancements in nanotechnology for improved safety and efficacy and results from safety and toxicology studies are discussed.