Review
Oncology
Stephanie Bath De Morais, Tatiana De Arruda Campos Brasil De Souza
Summary: L-asparaginase enzymes have been crucial in acute lymphoblastic leukemia therapy for over 40 years by depleting plasma L-asparagine essential for leukemia cell survival. While bacterial enzymes used in therapy have severe side-effects, efforts are focused on developing a therapeutic variant of human L-asparaginase to avoid these problems.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Genetics & Heredity
Masoumeh Fardi, Ali Mohammadi, Behzad Baradaran, Sahar Safaee
Summary: The study suggests that ZEB2 suppression through apoptosis induction could be an effective therapeutic method for myeloid leukemia, as it induces apoptosis, modulates gene expression, and reduces cell proliferation and viability.
CURRENT GENE THERAPY
(2021)
Article
Oncology
Yilin Wang, Jiandong Sun, Dong Xie, Ren Zhong, Shaoyong Si, Xiaotong Liu, Zhenghai Qu, Lirong Sun, Lingzhen Wang
Summary: This study investigated the effect of UV LED on leukemia cells under hypoxia and found that UV LED exacerbated apoptosis and proliferation inhibition in HL-60 cells through the regulation of caspase 3/9 and the Bcl-2/Bax ratio-dependent pathway. The application of UV LEDs in hypoxia conditions may be a promising approach to eliminate residual drug-resistant leukemia cells in autologous grafts.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rania H. H. Abd El-Hameed, Mosaad S. S. Mohamed, Samir M. M. Awad, Bardes B. B. Hassan, Marwa Abd El-Fattah Khodair, Yara E. E. Mansour
Summary: A series of benzo[h]chromenes, benzo[f]chromenes, and benzo[h]chromeno[2,3-d]pyrimidines were synthesized and compounds 5a and 6a showed promising anti-cancer activity. These compounds suppressed cell growth in HL-60 by inducing cell cycle arrest and triggering cell apoptosis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Marina de Souza Guimaraes, Jorge Javier Muso Cachumba, Cecilia Zorzi Bueno, Karin Mariana Torres-Obreque, Grace Veronica Ruiz Lara, Gisele Monteiro, Leandro Ramos Souza Barbosa, Adalberto Pessoa Jr, Carlota de Oliveira Rangel-Yagui
Summary: L-asparaginase is an important biological drug used for the treatment of Acute Lymphoblastic Leukemia. Encapsulation of L-asparaginase in liposomes provides protection against degradation and improves the pharmacokinetics of the drug. The study showed that the encapsulated L-asparaginase exhibited enhanced activity and improved protection against immune recognition and protease degradation in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Karthi Shanmugam, Vellingiri Vadivel, Santanu Kar Mahapatra
Summary: Myricitrin induces apoptosis in HL-60 leukemia cells by reducing mitochondrial membrane potential, increasing DNA fragmentation, inhibiting cell survival proteins, and inducing pro-apoptotic proteins.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Pharmacology & Pharmacy
Kyung-Sook Chung, Chae-Bin Yoo, Jeong-Hun Lee, Hwi-Ho Lee, Sang-Eun Park, Hee-Soo Han, Su-Yeon Lee, Byoung-Mok Kwon, Jung-Hye Choi, Kyung-Tae Lee
Summary: The study shows that 2'-HCA induces apoptosis in HL-60 cells via activation of the ROS-dependent JNK pathway, suggesting its potential as a therapeutic agent for leukemia.
Article
Nutrition & Dietetics
Mohamad Sitheek Abdul Rahman, Sivakumari Kanakarajan, Rajesh Selvaraj, Ashok Kamalanathan, Sabiha Fatima, Manal Abudawood, Nikhat J. Siddiqi, Humidah Alanazi, Bechan Sharma, Maria de Lourdes Pereira
Summary: The methanolic extract of Durio zibethinus fruits exhibits anticancer effects on HL-60 cells by inducing DNA damage and apoptosis. It causes cell cycle arrest and induction of apoptosis in the HL-60 cell line through an intrinsic mechanism. The study confirms the anticancer effects of the methanolic extract of Durian on HL-60 cells.
Article
Oncology
Jihong Lin, Lei Zhang, Zhiwei Wang, Qi Guan, Kai Bao, Lan Wu
Summary: COH-203 was found to have notable time- and dose-dependent antiproliferative effects on the human acute promyelocytic leukemia HL-60 cell line, resulting in cell cycle arrest at G(2)/M phase and induction of apoptosis. Western blot analysis revealed that upregulation of cyclin B was associated with G(2)/M arrest, while downregulated expression of Bcl-2 indicated that COH-203 may induce apoptosis in HL-60 cells via the mitochondrial pathway in a caspase-dependent manner.
Article
Biology
Neslihan Tekin Karacaer, Baris Kerimoglu, Talat Baran, Mehtap Tarhan, Ayfer Mentes, Kamile Ozturk
Summary: The investigation focused on reporting the fabrication, characterization, cytotoxicity, and apoptotic assessment of two new platinum based compounds on human leukemia cells. The results demonstrated dose-dependent cytotoxic effects and modulation of apoptotic gene expressions in the treated cells, suggesting the potential of these newly synthesized platinum compounds as anticancer drugs.
Article
Biochemistry & Molecular Biology
Maria Angeles Nunez-Sanchez, Maria Antonia Martinez-Sanchez, Marina Verdejo-Sanchez, Paula Garcia-Ibanez, Alba Oliva Bolarin, Bruno Ramos-Molina, Diego A. Moreno, Antonio J. Ruiz-Alcaraz
Summary: This study analyzed the anti-leukemic activity of various phytochemicals from cruciferous foods. The results showed that sulforaphane, chlorogenic acid, and cyanidin-3-glucoside exhibited potential as anti-leukemic agents, specifically targeting AML cells. Additionally, these compounds activated the NRF2/KEAP1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Amandda Evelin Silva-Carvalho, Nakaly Natiely de Oliveira, Julia Viana Lafeta Machado, Daniel Carneiro Moreira, Guilherme Dotto Brand, Jose Roberto S. A. Leite, Alexandra Placido, Peter Eaton, Felipe Saldanha-Araujo
Summary: The antioxidant peptide Salamandrin-I, isolated from the skin secretion of the fire salamander, has been found to exhibit anticancer activity in human leukemia cell line HL-60, resulting in reduced cell proliferation and cell cycle arrest. The cellular toxicity of Salamandrin-I may be related to pyroptosis, as indicated by loss of mitochondrial membrane potential and hyperexpression of inflammasome components. This study provides the first evidence of the anticancer potential of Salamandrin-I peptide and offers valuable insights for cancer therapy and drug design.
Article
Spectroscopy
Yingjia Zhao, Yunyun Zhang, Xinyue Liang, Shupeng Liu, Xiumei Cao, Na Chen, Zhenyi Chen, Jianshe Yan
Summary: In this study, Raman spectroscopy was used to monitor the differentiation process of HL-60 cells into granulocytes, showing a correlation between differentiation stages and Raman characteristic regions. Support vector machine was employed to distinguish between undifferentiated and differentiated cells, achieving an average classification accuracy exceeding 84%. The results suggest the potential application of Raman spectroscopy in monitoring cell differentiation.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Food Science & Technology
Yunyi Chen, Jiaojiao Liang, Xiao Liang, Jiebiao Chen, Yue Wang, Jinping Cao, Chongde Sun, Jiaming Ye, Qingjun Chen
Summary: Limonin, an important bioactive substance in citrus fruits, shows potential in cancer prevention and treatment. Through in vitro studies on HL-60 cells, it was found that limonin can inhibit cell proliferation and induce apoptosis positively correlated with dosage. Furthermore, Western blot results demonstrate that limonin activates the endogenous apoptosis pathway mediated by mitochondria by regulating apoptotic proteins, thus inhibiting cell proliferation and promoting apoptosis. Additionally, limonin down-regulates the expression of NQO1, suggesting a potential indirect mechanism of its anticancer activity through the regulation of antioxidant enzymes.
FOOD SCIENCE & NUTRITION
(2021)
Article
Environmental Sciences
Hsin-Yu Chen, Yi-Wen Jiang, Chao-Lin Kuo, Tzong-Der Way, Yu-Cheng Chou, Yuan-Shiun Chang, Jing-Gung Chung
ENVIRONMENTAL TOXICOLOGY
(2019)
Correction
Cell Biology
Po-Yuan Chen, Neng-Lang Shih, Wen-Rui Hao, Chun-Chao Chen, Ju-Chi Liu, Li-Chin Sung
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Correction
Cell Biology
Wen-Rui Hao, Li-Chin Sung, Chun-Chao Chen, Po-Yuan Chen, Tzu-Hurng Cheng, Hung-Hsing Chao, Ju-Chi Liu, Jin-Jer Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Environmental Sciences
Zheng-Yu Cheng, Fu-Shin Chueh, Shu-Fen Peng, Chia-Hsin Lin, Chao-Lin Kuo, Wen-Wen Huang, Po-Yuan Chen, Tzong-Der Way, Jing-Gung Chung
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shin-Hwar Wu, Fu-Shin Chueh, Yu-Cheng Chou, Yi-Shih Ma, Shu-Fen Peng, Chin-Chung Lin, Ching-Lung Liao, Po-Yuan Chen, Te-Chun Hsia, Jin-Cherng Lien
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Oncology
Kung-Wen Lu, Mei-Due Yang, Shu-Fen Peng, Jaw-Chyun Chen, Po-Yuan Chen, Hung-Yi Chen, Tai-Jung Lu, Fu-Shin Chueh, Jin-Cherng Lien, Kuang-Chi Lai, Kuo-Ching Liu, Yin-Ying Tai
ANTICANCER RESEARCH
(2020)
Article
Integrative & Complementary Medicine
Ju-Chi Liu, Po-Yuan Chen, Wen-Rui Hao, Yi-Chung Liu, Ping-Chiang Lyu, Hong-Jye Hong
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Yi-Ping Huang, Yi-Shih Ma, Chao-Lin Kuo, Ching-Lung Liao, Po-Yuan Chen, Shu-Fen Peng, Fei-Ting Hsu, Kuang-Chi Lai
Summary: In a mouse model experiment, DMC was found to significantly suppress human glioblastoma multiforme cells, with a better effect at a higher dose, while not affecting body weight. Additionally, DMC treatment had an impact on the expression of tumor-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Fu-Shin Chueh, Jin-Cherng Lien, Yu-Cheng Chou, Wen-Wen Huang, Yi-Ping Huang, Jye-Yu Huang, Jung-Yu Kuo, Wan-Ni Huang, Shou-Yi Sheng, Hao-Yun Tung, Hung-Yi Chen, Shu-Fen Peng
Article
Medicine, Research & Experimental
Hung-Sheng Shang, Kuo-Wei Chen, Jiann-Shang Chou, Shu-Fen Peng, Yung-Liang Chen, Po-Yuan Chen, Hsieh-Chou Huang, Hsu-Feng Lu, Hsin-Yu Chang, Yung-Luen Shih, Wen-Wen Huang
Review
Urology & Nephrology
Yu-Cheng Chou, Yuan-Hong Jiang, Tomor Harnod, Hsu-Tung Lee, Hann-Chorng Kuo
UROLOGICAL SCIENCE
(2019)
Article
Cell Biology
Po-Yuan Chen, Neng-Lang Shih, Wen-Rui Hao, Chun-Chao Chen, Ju-Chi Liu, Li-Chin Sung
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)