Article
Plant Sciences
Congyu Ma, Ning Sheng, Yuanyuan Li, Hao Zheng, Zhe Wang, Jinlan Zhang
Summary: This study comprehensively characterized the disposition, metabolism, and pharmacokinetics of representative active components of Dengzhan Shengmai capsule in rats with chronic cerebral hypoperfusion. The authors investigated the absorption, distribution, and pharmacokinetic profiles of various prototypes and metabolites using LC-MS/MS and LC-Q-TOF/MS techniques.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biology
Yifan Tu, Lu Wang, Yi Rong, Vincent Tam, Taijun Yin, Song Gao, Rashim Singh, Ming Hu
Summary: Research has shown that the distribution of orally administered phenolic drugs is mediated by intestinal glucuronidation and hepatic recycling, revealing a new mechanism of distribution called "Hepatoenteric Recycling (HER)."
Article
Biochemistry & Molecular Biology
Feri Eko Hermanto, Warsito Warsito, Muhaimin Rifa'i, Nashi Widodo
Summary: This study reveals the mechanism of the cholesterol-lowering effect of soy isoflavones through computational simulations. It suggests that Genistin and Genistein may be appropriate candidates for HMGCR inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Hongxia Liu, Ohji Kohmoto, Ayana Sakaguchi, Shota Hori, Misuzu Tochigi, Koji Tada, Yeonmi Lee, Keidai Kikuchi, Satoshi Ishizuka
Summary: This study demonstrated the significance of taurocholic acid in proximal gut leakiness and ruled out the influence of secondary bile acids.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medical Laboratory Technology
Huikuan Chu, Lu Jiang, Bei Gao, Nagsen Gautam, Jawaher A. Alamoudi, Sonja Lang, Yanhan Wang, Yi Duan, Yazen Alnouti, Edward E. Cable, Bernd Schnabl
Summary: The study demonstrates that the selective PPAR-delta agonist Seladelpar (MBX-8025) can prevent and treat ethanol-induced liver damage in mice by directly acting on PPAR delta in both the liver and the intestine. MBX-8025 effectively protects mice from ethanol-induced liver disease, restores ethanol-induced gut dysbiosis and gut barrier dysfunction.
TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jinxiao Zhai, Xiaoru Dong, Fenglian Yan, Hongsong Guo, Jinling Yang
Summary: Oleandrin is a highly lipid-soluble cardiac glycoside with extensive anti-cancer and anti-viral effects, but it also exhibits significant toxicity. This review summarizes the pharmacokinetic characteristics of oleandrin and suggests research approaches to ameliorate its pharmacokinetic behavior.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chien-Ming Hsieh, Li-Feng Hsu
Summary: In this study, a simulation approach was used to compare the suitability of different analytes in the bioequivalence study of ezetimibe. The results obtained through simulations showed that no single analyte had clear advantages in terms of discriminatory ability, and it was recommended to use a combination of ezetimibe and the total form as the indicator for bioequivalence assessment.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Kenta Maegawa, Haruka Koyama, Satoru Fukiya, Atsushi Yokota, Koichiro Ueda, Satoshi Ishizuka
Summary: The enterohepatic circulation of 12 alpha-hydroxylated bile acid is enhanced in rats fed a high-fat diet, and dietary supplementation of raffinose can normalize hepatic lipid accumulation by suppressing this circulation.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Engineering, Environmental
Huiming Cao, Zhen Zhou, Zhe Hu, Cuiyun Wei, Jie Li, Ling Wang, Guangliang Liu, Jie Zhang, Yawei Wang, Thanh Wang, Yong Liang
Summary: This study explored the role of enterohepatic circulation in the distribution and accumulation of per- and polyfluoroalkyl substances (PFAS) in biological systems. The findings demonstrated that enterohepatic circulation plays a critical role in the reabsorption, distribution, and bioaccumulation of PFAS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Yuanchen Chen, Wenfei Yu, Li Zhang, Linping Cao, Jun Ling, Kaizhen Liao, Guofeng Shen, Wei Du, Kangjie Chen, Meirong Zhao, Jian Wu, Hangbiao Jin
Summary: The study investigated the residues of neonicotinoid pesticides in human bile and found that human livers have low degradation ability for these pesticides. The main residues were nitenpyram and dinotefuran, which contributed to 86% of the total residual levels. The study also found different distribution patterns of neonicotinoids in blood and bile.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Ki-Young Huh, Se-jung Hwang, Sang-Yeob Park, Hye-Jung Lim, Mir-yung Jin, Jae-seong Oh, Kyung-Sang Yu, Jae-Yong Chung
Summary: The study evaluated the pharmacokinetic equivalence between SYO-1644 and Nexavar through a two-period trial, finding that a dose range between 120 and 125 mg of SYO-1644 achieved the highest proportion of bioequivalence.
Article
Pharmacology & Pharmacy
Wenjun Chen, Zourong Ruan, Jinliang Chen, Dandan Yang, Rong Shao, Honggang Lou, Bo Jiang
Summary: This study established the first population pharmacokinetic (PopPK) model describing the concentrations of HS-25 and its metabolite M1 simultaneously, with consideration of enterohepatic recirculation (EHC). Body weight was identified as a significant covariate affecting the clearance, apparent distribution volume, and the transfer rate of the metabolite compartment to the gallbladder compartment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Junwei Xiang, Zhengyan Zhang, Hongyi Xie, Chengcheng Zhang, Yan Bai, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: FXR, a nuclear receptor for bile acids, plays a key role in regulating metabolic pathways and improving various diseases. Bile acids link the intestine with the liver through the enterohepatic circulation, with different types of bile acids having diverse effects on the intestines, providing a foundation for new treatment methods.
Article
Gastroenterology & Hepatology
Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe, Masaya Araki, Yuki Murayama, Hitoshi Iwasaki, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Summary: CREB3L3 plays a crucial role in lipid metabolism in the liver and small intestine, controlling hepatic triglyceride and glucose metabolism. Ablation of CREB3L3 exacerbates hyperlipidemia and accelerates atherosclerosis in LDLR-/- mice, while hepatic nuclear CREB3L3 overexpression suppresses atherosclerosis. CREB3L3 has protective effects against atherosclerosis through its interaction with SREBPs under atherogenic conditions.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Kouassi R. Kpodo, Atul Chaudhari, Lori L. Schreier, Katarzyna B. Miska, Monika Proszkowiec-Weglarz
Summary: This study found that probiotic supplementation did not negatively affect bile acid metabolism and enterohepatic circulation in broiler chickens, but these effects were age dependent. These findings can contribute to the improvement of probiotic usage as an alternative to antibiotics in broiler chickens.
Article
Cell & Tissue Engineering
Chung-Kai Sun, Pei-Wei Weng, Jenny Zwei-Chieng Chang, Yi-Wen Lin, Fon-Yih Tsuang, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: Tissue engineering and regenerative medicine have emerged as a promising therapeutic approach for aging and diseased populations. This study developed a novel nano-gelatin/hydroxyapatite fibrous scaffold with metformin incorporation, showing enhanced healing potential in critical-size bone defects. The scaffold demonstrated proper structure and cellular compatibility, leading to improved bone regeneration outcomes in both in vitro and in vivo studies. More validation is needed before potential clinical applications.
TISSUE ENGINEERING PART A
(2022)
Article
Oncology
Yung-Yi Cheng, Teresa Zheng, Michael W. Chang, Jeffrey W. Dalley, Yu-Jen Chen, Tung-Hu Tsai, Chen-Hsi Hsieh
Summary: This study investigated the potential interaction between radiotherapy (RT) and tamoxifen treatment by evaluating the pharmacokinetics of tamoxifen during concurrent and sequential RT. The results demonstrated that RT may enhance the metabolism of tamoxifen to active metabolites, suggesting potential benefits of combining RT-tamoxifen for hormone-dependent breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tun-Sung Huang, Chih-Jung Ko, Jiunn-Chang Lin, Ming-Ling Hsu, Chun-Chuan Ko, Chih-Wen Chi, Tung-Hu Tsai, Yu-Jen Chen
Summary: We investigated the effects of 6-MITC and its derivatives on the differentiation and maturation of human myeloid dendritic cells, as well as on skin transplantation. The results showed that these compounds could inhibit the expression of CD1a and CD83, and have both enhancing and inhibitory effects on T cells and interferon-gamma. Additionally, they prolonged the survival of skin allografts and induced the accumulation of regulatory T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study demonstrates through experiments that remdesivir and its main metabolite, GS-441524, can cross the placenta, but remdesivir itself cannot directly enter the fetus. This finding suggests that caution should be taken when using remdesivir to treat COVID-19 during pregnancy.
Article
Medicine, Research & Experimental
Jung-Hung Chen, I-Hsin Lin, Chung-Kai Sun, Ling Yang, Thomas Y. Hsueh, Chin-Tsung Ting, Tung-Hu Tsai
Summary: This study reveals the transplacental transfer mechanism of acetaminophen and provides valuable information for its clinical use in pregnant women.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Jung-Hung Chen, I-Hsin Lin, Thomas Y. Hsueh, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study aimed to investigate the metabolism, distribution, and transplacental transfer mechanism of codeine and its metabolites in pregnant rats, as well as to assess the risk of medication for pregnant women.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemical Research Methods
Chung-Kai Sun, Tung-Hu Tsai
Summary: This review compiles and analyzes original articles on understanding possible herb-drug interactions between traditional herbs and four major pain medications-acetaminophen, aspirin, ibuprofen, and naproxen. The most common analytical method used is high-performance liquid chromatography with an isocratic eluent system coupled to biological sample clean-up, and a wide variety of detectors have been observed. Synergistic and anti-synergistic effects were observed for acetaminophen and aspirin, while only synergistic effects have been found for naproxen. Currently, no interactions have been reported for ibuprofen.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Medicine, Research & Experimental
Ling Yang, Tung-Hu Tsai
Summary: The combination treatment of Gastrodia elata extract and valproic acid (VPA) can increase the VPA levels in the brain, enhance its antiepileptic effects, and exert synergistic anticonvulsive effects by protecting neurons and altering dopamine metabolite levels. This synergistic effect is mediated by transporters at the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Tun-Pin Hsueh, Tung-Hu Tsai
Summary: This study investigated the diuretic effects and pharmacokinetics of Yin-Chen-Hao-Tang (YCHT) in combination with spironolactone in bile duct-ligated rats. The results showed that the coadministration of YCHT and spironolactone decreased urinary sodium excretion and urine output.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh
Summary: The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). The RT-drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The biodistribution of cabozantinib in the heart is modulated by off-target irradiation and SBRT doses simultaneously.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jui-Feng Lin, Chih-Wen Chi, Yu-Chuen Huang, Tung-Hu Tsai, Yu-Jen Chen
Summary: In this study, the anti-cancer effects of 6-MITC and its derivatives on chronic myelogenous leukemia cells were examined. It was found that they can induce cell death through suppressing the cell cycle and inducing autophagy and aberrant mitosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Su-Yin Chiang, Ming-Tsai Wey, Yu-Syuan Luo, Wei-Chung Shih, Dalaijamts Chimeddulam, Po-Chi Hsu, Hui-Fen Huang, Tung-Hu Tsai, Kuen-Yuh Wu
Summary: This study used a novel microdialysis sampling coupled with solid-phase extraction liquid chromatography-tandem mass spectrometry (MD-SPE-LC-MS/MS) to investigate the toxicokinetics (TK) of AA-I and AA-II and their corresponding aristolactams (AL-I and AL-II) in Sprague Dawley rats. Real-time monitoring revealed that AA-I was absorbed, distributed, and eliminated more rapidly than AA-II. The metabolism efficiency of AA-I to AL-I was higher compared to AA-II to AL-II. These findings support the hypothesis that differences in the in vivo metabolism of AA-I and AA-II may contribute to their differential toxicities.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: The aim of this study was to investigate the effects of herbal drug interactions on the biotransformation of molnupiravir and its metabolite NHC in the blood and brain. The results showed that molnupiravir was rapidly metabolized to NHC and penetrated into the brain.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, General & Internal
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study investigated the pharmacokinetics and transplacental transfer of molnupiravir, an antiviral drug for COVID-19, in pregnant rats. The results showed that molnupiravir is rapidly metabolized to NHC and crosses the blood-placenta barrier, suggesting its therapeutic effect in pregnant patients infected with COVID-19.
Article
Medicine, Research & Experimental
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Ling Yang, Tung-Yi Lin, Muh-Hwa Yang, Tung-Hu Tsai
Summary: Molnupiravir and its metabolite NHC can penetrate the blood-brain barrier and reach brain tissue, and the penetration of NHC can be modulated by NBMPR. These findings provide valuable information for understanding brain disorders in COVID-19 patients.
COMMUNICATIONS MEDICINE
(2023)