Review
Oncology
Hassan Mesgari, Samar Esmaelian, Kamyar Nasiri, Shabnam Ghasemzadeh, Parisa Doroudgar, Zahra Payandeh
Summary: This review emphasizes the importance of epigenetics in oral squamous cell carcinoma (OSCC). The study highlights the role of DNA methylation, histone modifications, and miRNAs in the development and progression of OSCC. Researchers are exploring targeted therapies, such as DNMT and HDAC inhibitors, to modify abnormal gene expression patterns. However, challenges remain in identifying reliable biomarkers and developing effective combination treatments.
Article
Cell Biology
Xing Xu, Jun Chen, Yan Li, Xiaojie Yang, Qing Wang, Yanjun Wen, Ming Yan, Jianjun Zhang, Qin Xu, Yan Wei, Wantao Chen, Xu Wang
Summary: Through genomics, metabolomics, and RNA omics studies, it was discovered that inhibition of squalene epoxidase synergistically increased the sensitivity of HNSCC cells to EZH2 inhibitors, providing a basis for the development of new therapeutic strategies for HNSCC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yi-Ping Hsieh, Ken-Chung Chen, Meng-Yen Chen, Ling-Yu Huang, An-Yu Su, Wei-Fan Chiang, Wen-Tsung Huang, Tze-Ta Huang
Summary: This study investigated the DNA methylation patterns of PTK6 during the development of OSCC and found that the DNA methylation of PTK6 was decreased in OSCC. Furthermore, upregulation of PTK6 promoted the proliferation, migration, and invasion of OSCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
N. Zlocowski, L. d Sosa, B. De la Cruz-Thea, C. B. Guido, M. G. Martin, J. H. Mukdsi, A. Torres, J. P. Petiti
Summary: The study examines the involvement of the EZH2/H3K27me3 axis in the proliferation of lactotroph tumor cells. The levels of EZH2 and H3K27me3 were found to be increased in murine experimental prolactin tumors, while p21 mRNA levels were low. H3K27me3 enrichment was observed in the promoter region of GH3 tumor cells. Inhibition of the EZH2/H3K27me3 axis blocked the proliferation of primary tumor cells and GH3 cells, suggesting it as a potential therapeutic target for prolactin pituitary neuroendocrine tumors (PitNETs).
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yongmei Yao, Yang Liu, Fengqin Jin, Zhaohua Meng
Summary: The study demonstrates that LINC00662 is up-regulated in oral squamous cell carcinoma (OSCC) and promotes tumor progression by repressing miR-144-3p expression and increasing EZH2 expression. The results suggest that LINC00662 acts as an oncogenic lncRNA in OSCC, accelerating tumor development through multiple genetic interactions.
YONSEI MEDICAL JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Ying Lou, Liuyang Ren, Lu Wang
Summary: In this study, the role of a novel circRNA, circ_0049396, and its underlying mechanism in oral squamous cell carcinoma (OSCC) were investigated. The findings showed that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on these results, circ_0049396 could be a potential therapeutic agent for OSCC.
Article
Biotechnology & Applied Microbiology
Xiu Liu, Xinrong Ma, Hongyu Li, Yu Wang, Minghui Mao, Chao Liang, Ying Hu
Summary: The study reveals that LINC00472 inhibits the growth of oral squamous cell carcinoma (OSCC) through the miR-455-3p/ELF3 axis, suggesting that LINC00472 and its targeted miR-455-3p/ELF3 axis may serve as valuable therapeutic targets for treating OSCC.
Article
Biochemistry & Molecular Biology
Jin Zhou, Jeremy M. Simon, Chengheng Liao, Cheng Zhang, Lianxin Hu, Giada Zurlo, Xijuan Liu, Cheng Fan, Austin Hepperla, Liwei Jia, Vanina Toffessi Tcheuyap, Hua Zhong, Roy Elias, Jin Ye, W. Mike Henne, Payal Kapur, Deepak Nijhawan, James Brugarolas, Qing Zhang
Summary: The JMJD6-DGAT1 axis plays a critical role in ccRCC tumor development. JMJD6 interacts with RBM39 and co-occupies the DGAT1 gene promoter to induce DGAT1 expression. Silencing JMJD6 reduces DGAT1 expression, leading to inhibition of lipid droplet formation and tumorigenesis. Pharmacological inhibition of DGAT1 suppresses lipid droplet formation and ccRCC tumorigenesis.
Article
Oncology
Wenjian Yao, Jianjun Wang, Li Zhu, Xiangbo Jia, Lei Xu, Xia Tian, Shuai Hu, Sen Wu, Li Wei
Summary: This study systematically identified the role of KDM4D/SYVN1/HMGB1 axis in the progression of esophageal squamous cell carcinoma, providing novel biomarkers and potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Nikhil Chandnani, Ishika Gupta, Vidhi Thakkar, Koustav Sarkar
Summary: According to the World Health Organization, cancer is the second leading cause of death. The number of cancer patients has been increasing in recent years, mainly due to lifestyle factors. YY1 is a transcription factor that regulates the activation and repression of genes associated with various cellular processes. EZH2 is an enzyme involved in histone modification and the regulation of CD8+ T cell fate. The association between EZH2 and YY1 has important implications in cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Dentistry, Oral Surgery & Medicine
Kaixin Wangzhou, Zishao Lu, Zhiying Lai, Wanren Fu, Cheng Liu, Yi Tan, Chunbo Hao
Summary: This study revealed that circ_0002141 is upregulated in OSCC tissues and cell lines, and its overexpression promotes the proliferation, migration, and invasion of OSCC cells while reducing apoptosis. It was also found that EGFR is a target of miR-1231 and circ_0002141 can sponge miR-1231 to upregulate EGFR expression in OSCC cells.
Article
Dentistry, Oral Surgery & Medicine
Xiaopeng Lu, Hongguo Xie
Summary: This study found that circ_0001971 was significantly up-regulated in oral squamous cell carcinoma (OSCC) and promoted the proliferation, migration, and glycolysis of OSCC cells through mediating the miR-107/FZD4 axis. Circ_0001971 might be a new effective target for OSCC treatment in the future.
Article
Biochemistry & Molecular Biology
Yilong Ai, Jing Song, Haigang Wei, Zhe Tang, Xia Li, Xiaozhi Lv, Hailing Luo, Siyuan Wu, Chen Zou
Summary: In this study, circ_0001461 was found to regulate cell proliferation, migration, and invasion in oral squamous cell carcinoma (OSCC) by sponging miR-145, and to promote resistance to TNF-a-induced apoptosis by modulating the miR-145/TLR4/NF-kB pathway. These findings provide insights into the novel regulatory mechanism of circ_0001461 in OSCC progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jessica E. Kenison, Zhongyan Wang, Kangkang Yang, Megan Snyder, Francisco J. Quintana, David H. Sherr
Summary: The study shows the central role of AhR in regulating multiple immune checkpoints in oral squamous cell carcinoma. Deletion of AhR in mouse OSCC cells results in complete rejection of tumors and increased T cell activation. This suggests AhR as a potential target for modulating immune response in cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Applied
Mohammed Nadim Sardoiwala, Surajit Karmakar, Subhasree Roy Choudhury
Summary: This study evaluates the neuroprotective potential of chitosan-based FTY720 nanoformulations for Parkinson's disease prevention by downregulating phosphorylated serine 129 (pSer129) alpha-Syn, showcasing its neuroprotective effects through anti-oxidative and anti-inflammatory mechanisms.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Biomaterials
Jignesh Mohanbhai Soni, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Shyam Sunder Sharma, Surajit Karmakar
Summary: Inflammatory Bowel Disease (IBD) is a complex inflammatory condition caused by interactions of environmental and genetic factors, requiring potent anti-inflammatory drugs for treatment. Melatonin-loaded chitosan nanoparticles show promising anti-inflammatory effects, effectively reducing inflammatory markers and improving disease symptoms.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Physical
Anup K. Srivastava, Babita Kaundal, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Surajit Karmakar
Summary: A highly stable protein nanoparticle networked rare-earth metal carbonate-grafted bio-composite membrane was developed for selective removal of non-reactive phosphate pollutants. The membrane exhibited excellent phosphate adsorption capacity and non-enzymatic phosphatase-like activity, enabling effective removal of phosphate pollutants from the aquatic system and promoting the recovery of the ecosystem.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Materials Science, Biomaterials
Ankur Sood, Atul Dev, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Shubhra Chaturvedi, Anil Kumar Mishra, Surajit Karmakar
Summary: Targeting active mitochondria can overcome radioresistance in tumors, leading to improved efficacy in radiotherapy. Nanoparticles designed for active mitochondrial targeting show potential for enhancing radiosensitization in hepatocellular carcinoma, with efficient drug loading capabilities.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Biomaterials
Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Parkinson's disease (PD) is a neurodegenerative disease caused by synucleinopathy. Recent studies have found that Hytrin can regulate energy homeostasis by activating the mitochondrial redox regulator IDH2, leading to attenuation of synucleinopathy in PD. However, the burst release kinetics of Hytrin restrict its therapeutic potential. Therefore, researchers aimed to improve Hytrin release kinetics through nanocarrier mediated delivery, and formulated Hytrin loaded polydopamine serotonin nanohybrid to replenish dopamine and serotonin for PD protection. The nanoformulation showed effective neurotherapeutic potential by improving Hytrin release profile and reducing PD symptoms. The neuroprotective effect was attributed to IDH2 induction and alpha-synuclein reduction, and the study revealed the direct physical interaction between IDH2 and alpha-synuclein, a hallmark of PD.
BIOMATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Atul Dev, Mohammed Nadim Sardoiwala, Mrunalini Boddu, Soni Jignesh MohanBhai, Subhasree Roy Choudhury, Surajit Karmakar
Summary: This study successfully developed 4oxo-fenretinide-loaded human serum albumin nanoparticles and evaluated their therapeutic potential in treating neuroblastoma. The nanoparticles showed significant inhibitory effects on cancer cell proliferation and tumor growth, and demonstrated the ability to modulate histone epigenetic modifiers and inhibit epithelial mesenchymal transition. The study suggests that these nanoparticles could be a promising treatment option for neuroblastoma.
ACS APPLIED NANO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Avinash Chandra Kushwaha, Atul Dev, Liku Biswal, Shyam Sunder Sharma, Subhasree Roy Choudhury, Surajit Karmakar
Summary: Melatonin significantly improves clinical symptoms of inflammatory bowel disease by reducing EZH2 expression, indicating its potential as a therapeutic target. The study highlights how melatonin regulates epigenetics to alleviate symptoms of IBD.
Article
Chemistry, Medicinal
Atul Dev, Mohammed Nadim Sardoiwala, Angela Sharma, Soni Jignesh MohanBhai, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Neuroblastoma is a pediatric tumor that is highly invasive and often metastasizes. Current treatment options are limited due to drug resistance and systemic toxicities. Researchers have developed a nanoformulation that delivers an acetyl pool and a chemotherapeutic drug to address these issues and successfully treat neuroblastoma in preclinical models.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Biomaterials
Avinash Chandra Kushwaha, Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Mahendran Jaganathan, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Osteoporosis is a metabolic bone disorder caused by an imbalance in bone remodeling. Genistein has been found to counteract osteoclastogenesis, but its usage is limited. This study utilised a nanoemulsified formulation of genistein with vitamin D to overcome these limitations and provide an efficient therapy for osteoporosis management.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Mohammed Nadim Sardoiwala, Ankur Sood, Liku Biswal, Subhasree Roy Choudhury, Surajit Karmakar
Summary: This study demonstrates the synthesis of magnetotransferrin by reconstituting apotransferrin to form iron oxide nanoparticles within the transferrin. The brain targeting potential of magnetotransferrin has been validated through in vivo/ex vivo imaging and immunogold staining of brain sections. This magnetic protein could be a potent candidate for brain targeting, bio-imaging, and therapy of neurological infirmities.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Shiwangi Gupta, Nishith Shrimali, Subhasree Roy Choudhury, Shyam Sunder Sharma, Prasenjit Guchhait, Surajit Karmakar
Summary: The study showed that colon targeted chitosan nanoparticles can enhance the anti-inflammatory effect of melatonin, indicating potential for UC treatment.
BIOMATERIALS ADVANCES
(2022)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.