Article
Health Care Sciences & Services
Young Chul Yoo, Won Sik Jang, Ki Jun Kim, Jung Hwa Hong, Sunmo Yang, Na Young Kim
Summary: The study found that the use of dexmedetomidine did not significantly affect biochemical recurrence (BCR) or radiographic progression in patients with prostate cancer after robot-assisted laparoscopic radical prostatectomy (RALP). Age, Gleason score, and pathological tumor stage were significant predictors of post-RALP BCR.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Dae Hyuk Chung, Jang Hee Han, Seung-Hwan Jeong, Hyeong Dong Yuk, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak
Summary: This study investigates the prognostic value of lymphatic invasion in prostate cancer patients and compares the recurrence rates between patients with lymphatic invasion and lymph node metastasis. The results show that lymphatic invasion is an independent prognostic factor that can complement lymph node status in predicting biochemical recurrence.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Leandro Blas, Masaki Shiota, Dai Takamatsu, Fumio Kinoshita, Takashi Matsumoto, Ken Lee, Keisuke Monji, Eiji Kashiwagi, Junichi Inokuchi, Masatoshi Eto
Summary: This study analyzed the evolution of BCR-free survival after radical prostatectomy and developed a nomogram incorporating postoperative PSA to predict BCR-free survival.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Shirin Moghaddam, Amirhossein Jalali, Amanda O'Neill, Lisa Murphy, Laura Gorman, Anne-Marie Reilly, Aine Heffernan, Thomas Lynch, Richard Power, Kieran J. O'Malley, Kristin A. Tasken, Viktor Berge, Vivi-Ann Solhaug, Helmut Klocker, T. Brendan Murphy, R. William Watson
Summary: This study developed a serum biomarker-based model to predict biochemical reoccurrence in prostate cancer patients after radical prostatectomy, demonstrating that the pre-operative biomarker PEDF can enhance the accuracy of clinical factors in predicting risk of biochemical reoccurrence. The integration of serum biomarkers with clinical variables significantly improved the predictive ability of biochemical reoccurrence, impacting patients' outcomes and quality of life.
Article
Urology & Nephrology
Tanan Bejrananda, Pitchaya Pliensiri
Summary: A novel nomogram was developed to predict biochemical recurrence after radical prostatectomy, identifying unfavorable factors for patient survival and assisting clinicians in making tailored treatment decisions.
Article
Oncology
Ye Yan, Lizhi Shao, Zhenyu Liu, Wei He, Guanyu Yang, Jiangang Liu, Haizhui Xia, Yuting Zhang, Huiying Chen, Cheng Liu, Min Lu, Lulin Ma, Kai Sun, Xuezhi Zhou, Xiongjun Ye, Lei Wang, Jie Tian, Jian Lu
Summary: The study utilized radiomic technique to extract features from MRI images of prostate cancer patients, and developed a predictive model for biochemical recurrence using deep learning algorithm. The model demonstrated superior predictive value compared to traditional stratification systems in two independent cohorts, allowing for early identification of high-risk patients and initiation of appropriate therapies.
Article
Immunology
Dechao Feng, Xu Shi, Facai Zhang, Qiao Xiong, Qiang Wei, Lu Yang
Summary: The study constructed and validated an energy metabolism-related gene prognostic index (EMRGPI) for predicting biochemical recurrence (BCR) in patients undergoing radical prostatectomy. EMRGPI was associated with BCR risk and immune cells. SDC1 and ADH1B were key genes in the risk formula.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hai-Zhui Xia, Hai Bi, Ye Yan, Bin Yang, Ruo-Zhuo Ma, Wei He, Xue-Hua Zhu, Zhi-Ying Zhang, Yu-Ting Zhang, Lu-Lin Ma, Xiao-Fei Hou, Gregory J. Wirth, Jian Lu
Summary: The study demonstrated that the newly developed nomogram significantly improved the accuracy in predicting BCRFS after RP, with PSA nadir and MTD based on MRI before surgery identified as independent predictors of BCR.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Enric Carbonell, Roger Matheu, Maria Muni, Joan Sureda, Monica Garcia-Sorroche, Maria Jose Ribal, Antonio Alcaraz, Antoni Vilaseca
Summary: Positive surgical margins (PSM) after radical prostatectomy are associated with a higher risk of biochemical recurrence (BCR). The presence of adverse characteristics such as length, multifocality, and Gleason score in the margins further increases the risk. However, subclassifying PSM with adverse features did not improve the predictive performance in this study cohort.
Article
Oncology
Adalgisa Guerra, Filipe Caseiro Alves, Kris Maes, Rui Maio, Geert Villeirs, Helena Mourino
Summary: This study assesses the impact of covariates derived from a predictive model for detecting extracapsular extension on biochemical recurrence-free survival (BCRFS) after robotic-assisted radical prostatectomy (RARP). The study includes retrospective data analysis, focusing on variables such as prostate-specific antigen (PSA) levels, patient age, prostate volume, MRI semantic features, and Grade Group (GG). The study highlights the importance of incorporating predictive MRI features pre-surgery in influencing early outcomes and clinical decision making.
Article
Oncology
Erica Huang, Linda My Huynh, Joshua Tran, Adam M. Gordon, Ryan Chandhoke, Blanca Morales, Douglas Skarecky, Thomas E. Ahlering
Summary: This observational study on 407 patients with biochemical recurrence (BCR) following radical prostatectomy (RP) shows that one-third of men can be managed with active observation without the risk of prostate-related death. These findings support the idea that a significant portion of men following RP develop a benign recurrence that does not require treatment intervention.
Article
Pathology
Oliver Best, Ashan Canagasingham, Zhixin Liu, Paul Doan, Anne-Maree Haynes, Warick Delprado, Fiona Maclean, Carlo Yuen, Phillip Stricker, James Thompson
Summary: The pathological grade of prostate cancer is the strongest predictor of recurrence. This study aims to determine whether the composite or index grade group is a better predictor of biochemical recurrence (BCR) in prostate cancer patients who underwent radical prostatectomy. The results showed that patients with a higher index grade group had a higher risk of BCR. Therefore, the index grade group should be used for post-operative counseling regarding prognosis and follow-up.
Article
Urology & Nephrology
Karl H. Tully, Max Schulmeyer, Julian Hanske, Moritz J. Reike, Marko Brock, Rudolf Moritz, Hendrik Juette, Andrea Tannapfel, Christian von Bodman, Joachim Noldus, Rein-Jueri Palisaar, Florian Roghmann
Summary: This study identified patients at risk for biochemical recurrence of prostate cancer after radical prostatectomy through intra-operative whole-mount frozen section. It found that patients with residual PCa in the secondary tumor resection face a higher risk of recurrence, highlighting the need for closer post-operative surveillance of this specific subgroup.
Article
Oncology
Xuefeng Qiu, Mengxia Chen, Haoli Yin, Qing Zhang, Haoyang Li, Suhan Guo, Yao Fu, Shiming Zang, Shuyue Ai, Feng Wang, Hongqian Guo
Summary: The study found that SUVmax, maximum diameter of the index tumor, and T stage on preoperative PSMA-ligand PET/CT were significantly associated with BCR. The PSMA-ligand PET/CT-based risk model showed good efficacy in predicting 2-year BCR after RP.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Yash Khanna, Vidyasagar Chinni, Kavitha Gnanasambantham, Richard O'Sullivan, Zita E. E. Ballok, Andrew Ryan, Shakher Ramdave, Dinesh Sivaratnam, Patrick Bowden, Mario Guerrieri, Weranja K. B. Ranasinghe, Mark Frydenberg
Summary: This study evaluated the role of multiparametric magnetic resonance imaging (mpMRI) and Gallium-68 (Ga-68)-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) in guiding salvage therapy for patients with biochemical recurrence (BCR) post-radical prostatectomy. The results showed that this imaging technique can help reduce unnecessary complications related to radiation therapy.
Article
Endocrinology & Metabolism
Jillian N. Eskra, Michael J. Schlicht, Maarten C. Bosland
Letter
Food Science & Technology
C. Frieke Kuper, Maarten C. Bosland
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Oncology
Nur Ozten, Katherine Vega, Joachim Liehr, Xi Huang, Lori Horton, Ercole L. Cavalieri, Eleanor G. Rogan, Maarten C. Bosland
Article
Nutrition & Dietetics
Maarten C. Bosland, Erika Enk, Joanne Schmoll, Michael J. Schlicht, Carla Randolph, Ryan J. Deaton, Hui Xie, Anne Zeleniuch-Jacquotte, Ikuko Kato
Summary: This study found that a 2-year soy protein supplementation did not have significant effects on body weight, blood pressure, blood lipids, iron status, and other clinical chemistry parameters in middle-aged to older men. Additional exploratory analysis suggested that equol production status might modulate the effects of soy on body weight and possibly blood pressure.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Maarten C. Bosland, Oluwarotimi S. Nettey, Adekoyejo A. Phillips, Charles C. Anunobi, Oluyemi Akinloye, Ima-Obong A. Ekanem, Ima-Abasi E. Bassey, Vikas Mehta, Virgilia Macias, Theodorus H. van Der Kwast, Adam B. Murphy
Summary: This study found the prevalence of subclinical prostate cancer among Nigerian men at autopsy to be 8.8%, with a crude prevalence of HGPIN at 20.6%. The results suggest that clinically asymptomatic prostate cancer is less common in Nigerians compared to other populations, despite shared genetic ancestry. Future studies with larger sample sizes are needed to further explore the natural history and true prevalence of prostate cancer in West Africa.
Article
Endocrinology & Metabolism
Maarten C. Bosland, Lori Horton, Mark S. Condon
Summary: This animal study does not support the idea that drinking green tea has a protective effect against prostate cancer.
Article
Pathology
Maarten C. Bosland, Michael J. Schlicht, Lori Horton, David L. McCormick
Summary: Animal models of prostate cancer are crucial for identifying chemopreventive treatments. This article introduces a reliable rat model that recapitulates human prostate cancer and has predictive value for human clinical trials. The article describes the induction protocol, diagnostic criteria, and current tumor induction protocol of the model.
TOXICOLOGIC PATHOLOGY
(2022)
Article
Oncology
Maarten C. Bosland, Michael J. Schlicht, Yibin Deng, Junxuan Lu
Summary: Selenomethionine did not prevent prostate cancer in both clinical and rat models, but the next-generation selenium forms MSeA and MSeC showed inhibitory effects in mouse models and human prostate cancer cells. However, in a chemically induced-androgen promoted carcinogenesis rat model where selenomethionine was not effective, MSeA and MSeC feeding did not show preventive effects. Possible reasons for the contrast between these findings could be differences in carcinogenic mechanisms, selenium dosage, delivery mode, and pharmacokinetics, or fundamental differences in selenium metabolism between rats and mice.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Maarten C. Bosland, Katherine Vega, Lori Horton, Michael J. Schlicht
Summary: The study aimed to determine if treatment with testosterone combined with nonestrogenic estrogen metabolites is sufficient for inducing a high incidence of prostate cancer in NBL rats. The results showed that long-term treatment with a nongenotoxic estrogen and testosterone, as well as uninhibited prostatic aromatase activity generating genotoxic estrogen, are all required for the development of prostate adenocarcinomas in NBL rats.
Article
Oncology
Jason Garcia, Kirsten D. Krieger, Candice Loitz, Lillian M. Perez, Zachary A. Richards, Yves Helou, Steve Kregel, Sasha Celada, Clementina A. Mesaros, Maarten Bosland, Peter H. Gann, Thomas E. Willnow, Donald Vander Griend, Rick Kittles, Gail S. Prins, Trevor Penning, Larisa Nonn
Summary: Vitamin D deficiency is associated with increased prostate cancer mortality and aggressiveness, particularly in African American populations. The megalin protein allows the import of testosterone bound to sex hormone binding globulin into prostate cells, which has implications for hormone regulation in the prostate. Megalin levels are regulated by 25-hydroxyvitamin D (25D) and reduced in localized prostate cancer, suggesting a mechanistic link between vitamin D, hormone levels, and prostate cancer disparities.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Maarten C. Bosland, Olayiwola B. Shittu, Edet E. Ikpi, Oluyemi Akinloye
Summary: Prostate cancer is a significant male malignancy in sub-Saharan countries, where screening, diagnosis, and treatment options are limited due to resource constraints. New approaches, such as one-step dipstick-type detection assays, can offer low-cost and quality control circumventing methods for prostate cancer detection and monitoring. Androgen deprivation treatments, like orchiectomy and low-cost drugs, provide feasible and affordable options to prolong survival and maintain a reasonable quality of life. However, clinical trials are needed to determine the most efficacious and well-tolerated androgen deprivation treatments for men with prostate cancer in low-resource regions.
ANNALS OF GLOBAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Jillian N. Eskra, Michael J. Schlicht, Maarten C. Bosland
SCIENTIFIC REPORTS
(2019)
Article
Public, Environmental & Occupational Health
Stevan Weine, Maarten Bosland, Chandrika Rao, Marcia Edison, Daniel Ansong, Stacey Chamberlain, Agnes Binagwaho
Summary: Global health education is facing challenges during the COVID-19 pandemic, but also has opportunities to develop and improve, including promoting sustainable remote engagement, strengthening collaboration with partners, and partnering in new ways with healthcare professionals from other countries.
ANNALS OF GLOBAL HEALTH
(2021)