Article
Pharmacology & Pharmacy
Fan Xie, Pedro Fardim, Guy Van den Mooter
Summary: Cellulose beads with high drug loading capacity were developed in this study, showing differences in drug dissolution between amorphous and crystalline forms, as well as a supersaturation phenomenon. The choice of solvent system during preparation greatly impacted the bead structure, resulting in different drug release behaviors. This study highlights the potential of dialdehyde cellulose beads as a carrier for improving poorly soluble drug dissolution and maintaining supersaturation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Applied
Linfan Shi, Zhouru Li, Jiayue Guo, Lingyan Kong, Zhongyang Ren, Wuyin Weng
Summary: In this study, ethylene gas was loaded into different pre-formed V-type starches using molecular encapsulation technique. The V-6a starch showed the most effective structure in encapsulating ethylene gas. The formation, structural characteristics, and morphological properties of the inclusion complexes (ICs) were investigated, along with the release kinetic properties of ethylene gas. The results demonstrated that this molecular encapsulation technology can provide precise control and targeted application of ethylene gas in the ripening process of vegetables and fruits.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Physical
Hadis Rostamabadi, Seid Reza Falsafi, Mohammad Mahdi Rostamabadi, Elham Assadpour, Seid Mahdi Jafari
Summary: Hydrophobicity and low aqueous-solubility are persistent challenges for the development and applications of drugs/nutraceuticals. Nanotechnology strategies and electrospraying technology are being utilized to address these challenges effectively.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Dixit Bhalani, Bhingaradiya Nutan, Avinash Kumar, Arvind K. Singh Chandel
Summary: The low water solubility of pharmacoactive molecules limits their pharmacological potential, and the pharmaceutical industry faces challenges in enhancing the solubility and bioavailability of drugs. However, there are various technologies available to improve the solubility of poorly water-soluble drugs.
Review
Chemistry, Applied
Camila C. V. Velloso, Marina M. Lopes, Alberto C. Badino, Cristiane S. Farinas
Summary: A systematic mapping of the use of starch-based systems for microbial encapsulation revealed a significant increase in publications on this topic in the past decade. Ionotropic gelation, emulsification, and spray drying were identified as the most commonly used techniques for starch-based microbial encapsulation. Starch plays important functions in the encapsulation matrix to enhance the survival of the microorganisms.
CARBOHYDRATE POLYMERS
(2023)
Article
Food Science & Technology
Huanqing Lei, Zhongjuan Liao, Langhong Wang, Xinan Zeng, Zhong Han
Summary: Porous starch was modified using PEF pretreatment and alcoholic-alkaline treatment to prepare P-GCWSS. The modified starch showed improved water solubility and adsorption capability, allowing effective encapsulation of zeaxanthin. The PEF-P-GCWSS increased zeaxanthin's solubility and provided a good protection for it.
Article
Agriculture, Multidisciplinary
Siyan Guo, Yanyan Zhao, Shuizhong Luo, Dongdong Mu, Xingjiang Li, Xiyang Zhong, Shaotong Jiang, Zhi Zheng
Summary: Gliadin nanoparticles stabilized by soluble soybean polysaccharide (SSPS) were prepared in this study and successfully encapsulated curcumin (Cur). The nanoparticles showed excellent stability and high delivery efficiency according to various tests and experiments.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Naaznee Mohan, John J. Mellem
Summary: This study investigated the structural and physicochemical characteristics of porous starches prepared using different methods. The results suggest that these porous starches may have potential applications in delivery systems, improving drug solubility, and dye adsorption.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xuyang Li, Yutang He, Jian Wang, Yumei Xie, Xinran Wang, Danshi Zhu, He Liu
Summary: This study investigated the anti-retrogradation effect of soybean soluble polysaccharides (SSPS) on instant rice and the possible interaction between SSPS and high-moisture starch products. The results showed that adding SSPS to instant rice could effectively inhibit starch retrogradation, improve water retention, and hinder the formation of ordered structures.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Applied
Yunxiang Ma, Min Li, Zidi Chen, Juan Feng, Ruixi Chen, Zhipeng Wang, Jinfeng Chen, Shenggui Zhang
Summary: In this study, butyric acid modified porous starch was successfully synthesized and used as stabilizers for Pickering emulsions encapsulating paclitaxel. The emulsions produced by higher substituted BA-modified porous starch showed smaller particle size and better stability. Furthermore, using higher substituted BA-modified porous starch significantly improved the encapsulation efficiency, retention rate, and release performance of paclitaxel during digestion. Therefore, BA-modified porous starch has potential application as an emulsifier in the food industry.
FOOD HYDROCOLLOIDS
(2023)
Review
Food Science & Technology
Yuan Zhao, Bo Li, Cuicui Li, Yangfan Xu, Yi Luo, Dongwu Liang, Chongxing Huang
Summary: Edible packaging is a sustainable product and technology that uses edible materials to package food, with polysaccharides being a reliable source for such packaging materials. While polysaccharides have excellent properties, they still need reasonable modifications to improve their film-forming, mechanical, barrier, and protective properties. Edible packaging has been widely applied in the food packaging industry, providing a zero-emission scheme and reducing dependence on petroleum resources.
Article
Agriculture, Dairy & Animal Science
H. T. Nguyen, M. R. Bedford, S-B Wu, N. K. Morgan
Summary: This study aimed to evaluate the importance of dietary soluble non-starch polysaccharides (sNSP) in broiler diets, showing that high sNSP content can increase ileal viscosity while wheat-based diets may lead to higher ileal viscosity and lower pH. Additionally, low sNSP diets may result in lower Lactobacillus content in the ileum and higher caecal pH and short chain fatty acid concentrations, emphasizing the importance of considering sNSP level when formulating diets for broilers.
Article
Thermodynamics
Duanle Li, Dongmin Wang, Yong Cui
Summary: The addition of aerogel can enhance the thermal resistance of aerogel-enhanced porous geopolymers (APG), but excessive addition can lower their mechanical strength. A content of approximately 6% aerogel can meet both the thermal conductivity and mechanical performance standards of APG.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Review
Pharmacology & Pharmacy
Xiaowen Liu, Limin Zhao, Baojian Wu, Fener Chen
Summary: Poorly water-soluble drugs pose a significant challenge in pharmaceutical development due to their low solubility, which can result in reduced bioavailability and therapeutic effectiveness. Efforts have been made to improve the solubility of these drugs for better pharmacokinetics and pharmacodynamics. Protein-based strategies, which offer natural advantages such as versatile interactions with hydrophobic drugs, biocompatibility, biodegradation, and protein metabolism, have gained special interest. This review summarizes the advancements in using proteins, including plant proteins, mammalian proteins, and recombinant proteins, to enhance the water solubility of poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Minhao Zhao, Zeyu Guan, Ning Tang, Yongqiang Cheng
Summary: This review summarizes the recent progress made in Poria cocos polysaccharide (PCP) in four aspects: extraction, separation, and purification methods; structural characterization and identification; related bioactivities and mechanism of action; and structure-activity relationships. PCP can be categorized into water-soluble polysaccharide (WPCP) and alkaline-soluble polysaccharide (APCP), which have different structures and bioactivities. WPCP has diverse structures and exhibits various bioactivities, such as anti-tumor, anti-depressant, anti-Alzheimer, anti-atherosclerosis, and hepatoprotective effects. APCP has simpler structures and its studies mainly focus on anti-tumor, anti-inflammatory, and immunomodulatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Sanaz Jauanmardi, Ali Mohammad Tamaddon, Mahmoud Reza Aghamaali, Ladan Ghahramani, Samira Sadat Abolmaali
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Mahboobeh Jafari, Samira Sadat Abolmaali, Haniyeh Najafi, Ali Mohammad Tamaddon
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Materials Science, Multidisciplinary
Zahra Rahiminezhad, Ali Mohammad Tamaddon, Sedigheh Borandeh, Samira Sadat Abolmaali
APPLIED MATERIALS TODAY
(2020)
Article
Nanoscience & Nanotechnology
Mehdi Abedi, Samira Sadat Abolmaali, Mozhgan Abedanzadeh, Fatemeh Farjadian, Soliman Mohammadi Samani, Ali Mohammad Tamaddon
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Food Science & Technology
Zeinab Qazanfarzadeh, Mahdi Kadivar, Hajar Shekarchizadeh, Raffaele Porta
Summary: The study reveals that rye prolamins films are less hydrophobic and more flexible compared to corn zein films, and the composite films exhibit good miscibility of the two biopolymers.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Niloufar Nourmohammadi, Sabihe Soleimanian-Zad, Hajar Shekarchizadeh
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Food Science & Technology
Zohreh Khezri, Hajar Shekarchizadeh, Milad Fathi
Summary: Opopanax gum/gelatin nanofibres were successfully produced by electrospinning, showing enhanced thermal stability and encapsulation efficiency for garlic essential oil. The inclusion of 10% garlic essential oil in the nanofibres was found to be optimal, increasing stability to over 60 days at 25 degrees Celsius. This study demonstrates the potential of opopanax gum/gelatin nanofibres as a coating material for improving essential oil stability.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Zeinab Qazanfarzadeh, Mahdi Kadivar, Hajar Shekarchizadeh, Raffaele Porta
Summary: Lipophilization of Secalin protein improved its functional properties by increasing surface hydrophobicity and hydrophobic interactions, reducing solubility and water absorption, and enhancing oil absorption. Emulsifying capacity and stability were enhanced with low levels of acylation, while foaming capacity increased with higher concentrations of acylating agent. Application in food preparations as a protein additive is recommended.
Article
Food Science & Technology
Zeinab Qazanfarzadeh, Mahdi Kadivar, Hajar Shekarchizadeh, Raffaele Porta
Summary: Secalin underwent acylation reaction to prepare protein-based films with reduced hydrophilicity for food packaging applications. The acylation process significantly improved water sensitivity of the films, while enhancing mechanical properties and surface uniformity.
Article
Pharmacology & Pharmacy
Nasser Gholijani, Samira-Sadat Abolmaali, Kurosh Kalantar, Mohammad-Hadi Ravanrooy
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
Review
Materials Science, Biomaterials
Ghazal Farahavar, Samira Sadat Abolmaali, Nasser Gholijani, Foroogh Nejatollahi
BIOMATERIALS SCIENCE
(2019)
Review
Nanoscience & Nanotechnology
Vahid Aliamradni, Samira Sadat Abolmaali, Sedigheh Borandeh
JOURNAL OF NANOSTRUCTURES
(2019)
Article
Chemistry, Multidisciplinary
Maryam Monajati, AliMohammad Tamaddon, Gholamhossein Yousefi, Samira Sadat Abolmaali, Rassoul Dinarvand
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)