Article
Nutrition & Dietetics
Hong Qin, Ziyu Song, Horia Shaukat, Wenya Zheng
Summary: GEN can improve hepatic lipid metabolism by activating ERβ and modulating the signals of protein kinases, leading to reduced lipogenesis. These findings provide novel insights into the regulatory mechanism of ERβ in hepatic lipid metabolism and may help to further understand the role of food-derived phytoestrogens in preventing and treating hepatic steatosis in postmenopausal women.
Article
Plant Sciences
Matheus Luis Oliveira Cunha, Lara Caroline Alves de Oliveira, Vinicius Martins Silva, Gabriel Sgarbiero Montanha, Andre Rodrigues dos Reis
Summary: This study investigated the effects of selenium application on various aspects of peanut plants, including photosynthetic pigments, oxidant metabolism, flavonoids biosynthesis, nodulation, and agronomic traits. The results showed that selenium fertilization increased the concentration of photosynthetic pigments, activity of antioxidant enzymes, as well as growth and yield of peanut plants. It also improved nitrogen assimilation efficiency and promoted the synthesis of certain compounds in the roots, leading to increased nodulation and transportation of nutrients to the leaves.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Xia Wang, Dinggang Li, Xiangqin Zheng, Yifan Hong, Jie Zhao, Wei Deng, Mingxin Wang, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu
Summary: This study investigates the molecular mechanism of testicular damage caused by Di-(2-ethylhexyl) phthalate (DEHP). The findings suggest that DEHP exposure leads to histopathological alterations in prepubertal testes and significant changes in lipid metabolism and ferroptosis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sri Rahayu, Nana Luthfiana, Sasangka Prasetyawan, Ivakhul Anzila
Summary: This study investigated the potential effect of M. crenata ethanol extract as antioxidants through the expression levels of SOD1 and Nrf2 in rat testes. Phytochemical analysis showed the presence of quercetin and genistein in the extract, which exhibited strong antioxidant activity. The expression of Nrf2 and SOD1 in the testes of the rats was influenced by the extract.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Riva Shmulevich, Valery Krizhanovsky
Summary: Senescence is a crucial biological process that can block tumorigenesis and limit tissue damage, but accumulation of senescent cells can promote age-related diseases. Recent advances have shown the significant role of cellular metabolism in regulating cell senescence, and future research should focus on elucidating metabolic mechanisms to develop new therapeutic strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Environmental Sciences
Shengfang Wen, Chao Liu, Youwei Wang, Yannan Xue, Xueting Wang, Jinhua Wang, Xiaoming Xia, Young Mo Kim
Summary: Triflumezopyrim is an effective pesticide for controlling rice planthoppers, but it may have adverse effects on earthworms by causing oxidative stress and DNA damage.
Article
Developmental Biology
Kelsey R. Pool, Tayler C. Kent, Luoyang Ding, Callum Connolly, Kevin J. Foster, Gereltsetseg Enkhbat, Megan H. Ryan, Dominique Blache
Summary: This study investigates the impact of consuming estrogenic pasture on sheep reproduction using a longitudinal sheep model. The study finds that consuming estrogenic pasture leads to decreases in sperm quality and affects the structural integrity of the spermatozoa. This study provides the first evidence that estrogenic pasture compromises ram reproduction.
Article
Biochemistry & Molecular Biology
Jiahao Chen, Jingxin Liu, Pengguihang Zeng, Cai Zhao, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Wenjie Chen, Junjun Ding
Summary: Estrogen (E2) and BRCA1 deficiency synergistically induce DNA damage in breast cancer cells, possibly involving transcriptional activation of ER genes and changes in DNA damage distribution.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hivi M. Mahmoud, Ardawan F. Ali, Dhia Al-Timimi
Summary: The study reveals a correlation between low zinc levels and high oxidative DNA damage in diabetic patients, with zinc supplementation shown to decrease DNA damage levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma
Summary: The study investigated the preventive effects and mechanisms of genistein (GEN) on production performance and metabolic disorders in broilers under chronic heat stress (HS). The results showed that GEN improved growth performance and hormone secretion in broilers under HS, reduced liver index and abdominal fat rate, and alleviated excessive lipid accumulation in the liver and serum. GEN also effectively regulated gene expression related to lipid metabolism and improved hepatic mitochondrial energetic dysfunction. Therefore, GEN can be used as a feed additive to alleviate heat stress in broilers.
Article
Biochemistry & Molecular Biology
Sri R. Chilukoti, Chittaranjan Sahu, Gopabandhu Jena
Summary: Eugenol protects diabetic germ cells, improves sperm quality, reduces DNA damage and apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Applied
Ahmed A. Fadda, Eman El-Gendy, Hala M. Refat, Eman H. Tawfik
Summary: In this study, a series of new porphyrin derivatives were successfully synthesized and showed promising activity as antimicrobial and antioxidant agents. The compounds 4c, 4e, 4g, 5c, and 5d exhibited the highest antimicrobial activity, while compounds 4a, 4f, 5a, 5b, and 5d showed the highest antioxidant activity.
Article
Oncology
Santosh Timilsina, Subapriya Rajamanickam, Arhan Rao, Panneerdoss Subbarayalu, Saif Nirzhor, Nourhan Abdelfattah, Suryavathi Viswanadhapalli, Yidong Chen, Ismail Jatoi, Andrew Brenner, Manjeet K. Rao, Ratna Vadlamudi, Virginia Kaklamani
Summary: The anti-depressant imipramine can block the growth of breast cancer by inducing cell cycle arrest and inhibiting DNA repair activities. Imipramine inhibits the expression of cell cycle and DNA repair associated proteins and also inhibits estrogen receptor signaling. It can enhance the sensitivity of triple-negative breast cancer to PARP inhibitors and endocrine resistant breast cancer to anti-estrogens.
Article
Multidisciplinary Sciences
Jalpa Patel, Hiral Chaudhary, Kiransinh Rajput, Bhavin Parekh, Rushikesh Joshi
Summary: PCOS is an endocrine disorder characterized by hormonal imbalances and metabolic disturbances in women of reproductive age. This study investigates the correlation between gut microbial enzymes β-glucuronidase and β-glucosidase and PCOS, as well as their association with hormone levels and other clinical parameters. The results show significantly higher levels of β-glucuronidase and β-glucosidase activity in PCOS women compared to controls, and intriguing connections with hormone levels. These microbial enzymes may serve as biomarkers for early detection and monitoring of PCOS, leading to improved diagnosis and treatment options.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Sebastian T. Soukup, Ann Katrin Engelbert, Bernhard Watzl, Achim Bub, Sabine E. Kulling
Summary: This study investigated the microbial metabolite profile of soy isoflavones and classified the population into 5 isoflavone metabotypes based on their metabolite profiles. These metabotypes differed significantly in their metabolite composition and estrogenic potency.
Article
Urology & Nephrology
Marinus J. C. Eijkemans, Willem van der Wal, Leida J. Reijnders, Kit C. B. Roes, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Corey Pelletier, Matthew Magestro, Bernard Zonnenberg
AMERICAN JOURNAL OF KIDNEY DISEASES
(2015)
Article
Economics
Francis Vekeman, Matthew Magestro, Paul Karner, Mei Sheng Duh, Timothy Nichols, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Bernard A. Zonnenberg
JOURNAL OF MEDICAL ECONOMICS
(2015)
Article
Reproductive Biology
Roger W. L. Godschalk, Kimberly Vanhees, Lou Maas, Marie-Jose Drittij, Danielle Pachen, Sahar van Waalwijk van Doorn-Khosrovani, Frederik J. van Schooten, Guido R. M. M. Haenen
REPRODUCTIVE TOXICOLOGY
(2016)
Letter
Hematology
Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Kimberly Vanhees, Erik Ruijters, Frederik-Jan van Schooten
EUROPEAN JOURNAL OF HAEMATOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Kimberly Vanhees, Frederik J. van Schooten, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Stefan van Helden, Armelle Munnia, Marco Peluso, Jacob J. Briede, Guido R. M. M. Haenen, Roger W. L. Godschalk
FREE RADICAL BIOLOGY AND MEDICINE
(2013)
Article
Toxicology
Kimberly Vanhees, Laura de Bock, Roger W. L. Godschalk, Frederik J. van Schooten, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani
TOXICOLOGICAL SCIENCES
(2011)
Article
Pharmacology & Pharmacy
Kimberly Vanhees, Roger W. Godschalk, Anneke Sanders, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Frederik J. van Schooten
Editorial Material
Oncology
S. B. van Waalwijk van Doorn-Khosrovani, A. Pisters-van Roy, L. van Saase, M. van der Graaff, J. Gijzen, S. Sleijfer, L. R. Hoes, J. M. van Berge Henegouwen, H. van der Wijngaart, D. L. van der Velden, E. van Werkhoven, V. P. Retel, W. H. van Harten, A. D. R. Huitema, L. Timmers, H. Gelderblom, H. M. W. Verheul, E. E. Voest
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
S. Barjesteh Van Waalwijk Van Doorn-Khosrovani, A. Pisters-van Roy, L. Timmers, L. van Saase, T. H. L. Tran, L. J. Zeverijn, P. Evers, H. Gelderblom, H. M. W. Verheul, E. F. Smit, N. Blijlevens, F. A. Eskens, H. J. Bloemendal, E. E. Voest
ANNALS OF ONCOLOGY
(2020)
Meeting Abstract
Oncology
Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Anke Pisters-van Roy, Haiko Bloemendal, Hans Gelderblom
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ildiko Adam, Marcelien Callenbach, Bertalan Nemeth, Rick A. Vreman, Cecilia Tollin, Johan Ponten, Dalia Dawoud, Jamie Elvidge, Nick Crabb, Sahar Barjesteh Van Waalwijk Van Doorn-Khosrovani, Anke Pisters-van Roy, Aron Vincziczki, Emad Almomani, Maja Vajagic, Z. Gulsen Oner, Mirna Matni, Jurij Furst, Rabia Kahveci, Wim G. Goettsch, Zoltan Kalo
Summary: Outcome-based reimbursement models can reduce financial risk to health care payers in cases of uncertainty or heterogeneity. However, in lower income countries, financial based agreements are relied upon to manage uncertainties associated with new therapies. This study explores potential barriers and solutions to outcome-based agreements in Central and Eastern Europe and the Middle East, and presents recommendations for implementing these models.
FRONTIERS IN MEDICINE
(2022)
Meeting Abstract
Oncology
H. Gelderblom, A. Edsjo, H. E. G. Russnes, U. N. Lassen, A. Helland, E. Hallersjo Hult, B. Ryll, I. Lugowska, J-Y. Blay, R. S. Falk, S. van Waalwijk van Doorn-Khosrovani, K. Steen Carlsson, K. Peltola, A. Stenzinger, E. Vrdoljak, J. Oliveira, S. F. Haj Mohammad, H. M. W. Verheul, E. E. Voest, K. Tasken
ANNALS OF ONCOLOGY
(2023)
Meeting Abstract
Oncology
L. Timmers, M. Cozijnsen, S. van Waalwijk van Doorn-Khosrovani, J. de Boer, R. Dupree
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Jannie Janssen, Lou M. Maas, Roger W. L. Godschalk, Frederik J. van Schooten