Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo

(2019) Yin-Chen Hsiao et al.   ENVIRONMENTAL TOXICOLOGY

Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects

(2019) Hee-Sung Chae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural products as multidrug resistance modulators in cancer

(2019) Amit Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells

(2019) Su Hyun Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCL-2 proteins and apoptosis: Recent insights and unknowns

(2018) Frank Edlich   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer

(2018) Karen K. L. Chan et al.   Cancer Cell International

Genistein as a Potential Anticancer Agent Against Head and Neck Squamous Cell Carcinoma

(2018) Fatima Ardito et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Apoptosis: A Target for Anticancer Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

(2018) Chuan-Long Guo et al.   Marine Drugs

Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G 0 /G 1 cell cycle arrest and regulation of STAT3 signalling pathway

(2018) Yi-liang Bi et al.   PHYTOMEDICINE

Mitochondria in cancer: in the aspects of tumorigenesis and targeted therapy

(2018) Narayanasamy Badrinath et al.   CARCINOGENESIS

Adverse drug reactions of anticancer drugs derived from natural sources

(2018) Devesh Tewari et al.   FOOD AND CHEMICAL TOXICOLOGY

Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences

(2018) Bowen Fu et al.   Frontiers in Pharmacology

Genistein decreases A549 cell viability via inhibition of the PI3K/AKT/HIF-1α/VEGF and NF-κB/COX-2 signaling pathways

(2017) Juan Zhang et al.   Molecular Medicine Reports

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

(2017) Richard W. Birkinshaw et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell cycle regulation and anticancer drug discovery

(2017) Bai Jingwen et al.   Cancer Biology & Medicine

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

Evidence for genistein as a mitochondriotropic molecule

(2016) Marcos Roberto de Oliveira   MITOCHONDRION

Major apoptotic mechanisms and genes involved in apoptosis

(2016) Yağmur Kiraz et al.   TUMOR BIOLOGY

Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

(2016) Yang Yang et al.   Oncology Letters

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

(2015) Concepción Sánchez-Martínez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemopreventive role of food-derived proteins and peptides: A review

(2015) Blanca Hernández-Ledesma et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers

(2015) Nadine Houédé et al.   PHARMACOLOGY & THERAPEUTICS

Genistein and Cancer: Current Status, Challenges, and Future Directions

(2015) Carmela Spagnuolo et al.   Advances in Nutrition

Plant-derived epigenetic modulators for cancer treatment and prevention

(2014) Michael Schnekenburger et al.   BIOTECHNOLOGY ADVANCES

The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines

(2014) Friederike Schmidt et al.   ONCOLOGY REPORTS

Saffron and natural carotenoids: Biochemical activities and anti-tumor effects

(2013) Azam Bolhassani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Phytoestrogens induce apoptosis through a mitochondria/caspase pathway in human breast cancer cells

(2013) F.-P. Chen et al.   CLIMACTERIC

Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation

(2013) Junkyu Han et al.   CYTOTECHNOLOGY

Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells

(2013) ZHIYU ZHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Soy isoflavones and prostate cancer: A review of molecular mechanisms

(2013) Abeer M. Mahmoud et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis

(2013) Yong Wang et al.   PLoS One

Genistein Potentiates the Anti-cancer Effects of Gemcitabine in Human Osteosarcoma via the Downregulation of Akt and Nuclear Factor-κB Pathway

(2012) Chengzhen Liang et al.   Anti-Cancer Agents in Medicinal Chemistry

Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

(2012) Stamatios Liokatis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

(2011) Chahrazade Kantari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Checkpoint control and cancer

(2011) R H Medema et al.   ONCOGENE

Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Apoptosis Induced by Genistein in Human Cervical Cancer Cells

(2009) Su-Hyeon Kim et al.   Annals of the New York Academy of Sciences

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4)

(2008) Yolanda Sánchez et al.   BIOCHEMICAL PHARMACOLOGY