Article
Cell Biology
Xiaoxia Liu, Ying Lan, Li Zhang, Xi Ye, Qingrong Shen, Guangyan Mo, Xiaoyu Chen
Summary: This study aimed to identify the pharmacological targets and anti-colorectal cancer (CRC) mechanisms of genistein, characterized by autophagy-related processes and pathways, through a systematic bioinformatics approach. The results revealed 10 core genistein-anti-CRC targets related to autophagy, including EGFR and ESR1, and showed that the biological processes of these targets might regulate multiple molecular pathways, including the estrogen signaling pathway.
Review
Biochemistry & Molecular Biology
Mateusz Kciuk, Manzar Alam, Nemat Ali, Summya Rashid, Pola Glowacka, Rajamanikandan Sundaraj, Ismail Celik, Esam Bashir Yahya, Amit Dubey, Enfale Zerroug, Renata Kontek
Summary: Cellular signaling pathways play a significant role in maintaining the balance between cell proliferation and apoptosis, making them rational targets for cancer prevention and treatment. Epigallocatechin-3-gallate (EGCG), the major phenolic compound in green tea, has been shown to regulate important cellular signaling pathways involved in the pathophysiology of cancer. EGCG has demonstrated anti-proliferative, anti-inflammatory, and apoptosis-inducing effects, as well as the ability to induce epigenetic changes. Preclinical and clinical studies suggest that EGCG may have therapeutic potential for various disorders, including cancer.
Review
Chemistry, Medicinal
Fahimeh Zamani-Garmsiri, Solaleh Emamgholipour, Soheil Rahmani Fard, Ghasem Ghasempour, Roya Jahangard Ahvazi, Reza Meshkani
Summary: Polyphenols have potential benefits in health status, especially in obesity-related metabolic disorders, but further high-quality research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Review
Food Science & Technology
Saied A. Aboushanab, Shaimaa M. Khedr, Irina F. Gette, Irina G. Danilova, Natalia A. Kolberg, Gokare A. Ravishankar, Ranga Rao Ambati, Elena G. Kovaleva
Summary: Isoflavones, the most abundant category of plant polyphenols, have demonstrated health benefits but studies remain variable and controversial, requiring further standardized analysis to explore their potential therapeutic effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Medicine, Research & Experimental
Semim Akhtar Ahmed, Dey Parama, Enush Daimari, Sosmitha Girisa, Kishore Banik, Choudhary Harsha, Uma Dutta, Ajaikumar B. Kunnumakkara
Summary: This review summarizes the potential of a compound called apigenin and its analogs in modulating key molecular targets for the prevention and treatment of various types of cancer. Research has shown that apigenin and its analogs are effective in modulating important molecular targets and signaling pathways involved in cancer development and progression, as well as inhibiting chemoresistance and radioresistance in cancer cells. Additionally, the safety of apigenin has been demonstrated, along with the use of nanotechnological approaches to improve its bioavailability.
Article
Chemistry, Multidisciplinary
Kyoung Sub Kim, Kun Na, You Han Bae
Summary: Oral administration of pharmaceuticals is challenging due to solubility, size, enzymes, and transporters. Efforts have been made to enhance oral bioavailability using nanoparticles with specific and nonspecific uptake pathways. However, translating results from animal models to humans is difficult and inconsistent. Parameters for translational potential in designing oral nanoparticles are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Giusy Rita Caponio, Tamara Lippolis, Valeria Tutino, Isabella Gigante, Valentina De Nunzio, Rosa Anna Milella, Marica Gasparro, Maria Notarnicola
Summary: Nutraceuticals have gained popularity due to their physiological and potential health effects. This review focuses on the major constituents of the Mediterranean diet and their effects on human health, specifically in the gastrointestinal tract. It provides a deeper understanding of nutraceuticals' therapeutic purpose and suggests personalized dietary components for adjuvant therapies.
Editorial Material
Nanoscience & Nanotechnology
Taskeen Iqbal Janjua, Yuxue Cao, Chengzhong Yu, Amirali Popat
Summary: Silica nanoparticles have shown promising safety, efficacy, and viability in clinical trials for various biomedical applications such as oral drug delivery, diagnostics, and therapy, indicating their potential in the field.
NATURE REVIEWS MATERIALS
(2021)
Article
Chemistry, Medicinal
Huahui Zeng, Duanjie Xu, Yagang Song, Shuo Tian, Jingyi Qiao, Zhanzhan Li, Lingzhou Zhao, Hui Shi, Yueyue Zhou, Shuo Li, Ying Luo, Jiashi Li, Mingsan Miao, Xiangxiang Wu
Summary: The researchers synthesized and evaluated nine prodrugs, among which SS-12 showed the most promising efficacy against breast cancer, with improved bioavailability and longer retention time compared to stachydrine.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Smitha S. Bhat, Shashanka K. Prasad, Chandan Shivamallu, Kollur Shiva Prasad, Asad Syed, Pruthvish Reddy, Charley A. Cull, Raghavendra G. Amachawadi
Summary: Genistein, an isoflavonoid found in high quantities in soybeans, has a wide range of bioactives and is extensively studied for its tumoricidal effects. It affects cancer cell proliferation through various pathways, but the observed activities are time- and dose-dependent, and show varying results in women depending on physiological parameters such as menopausal states.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
News Item
Biochemistry & Molecular Biology
Paul Webster
Summary: Cancer immunotherapy has generated significant excitement, but the potential lies in antibody-drug conjugates, proteolysis-targeting chimeras, and liquid biopsy for early detection.
Article
Pharmacology & Pharmacy
Vaishnavi S. S. Shete, Darshan R. R. Telange, Nilesh M. M. Mahajan, Anil M. M. Pethe, Debarshi K. K. Mahapatra
Summary: The Phospholipon((R))90H complex of genistein (GPLC) was prepared to enhance its biopharmaceutical properties and anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Paula Garcia-Ibanez, Maria A. Nunez-Sanchez, Alba Oliva-Bolarin, Maria A. Martinez-Sanchez, Bruno Ramos-Molina, Antonio J. Ruiz-Alcaraz, Diego A. Moreno
Summary: Digestates from red cabbage sprouts and red radish sprouts, which are derived from cruciferous vegetables, have anti-inflammatory effects and could be used as dietary coadjuvants in the treatment of chronic inflammation. These findings were observed in an in vitro model, where the bioaccessible compounds from the sprouts significantly decreased the production of pro-inflammatory cytokines in stimulated cells.
Review
Pharmacology & Pharmacy
Barbara Costa, Nuno Vale
Summary: The COVID-19 pandemic has posed an unprecedented challenge in finding effective drugs, with anticancer drugs showing potential for repurposing. Clinical management needs further improvement to effectively treat this infection.
Article
Pharmacology & Pharmacy
Preeti Tanaji Mane, Balaji Sopanrao Wakure, Pravin Shridhar Wakte
Summary: This study investigated the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. It was found that the optimized nanosponge formulation EF2 significantly increased the solubility and dissolution of exemestane in vitro. In vivo experiments showed that EF2 treatment reduced tumor burden and improved hematological parameters in breast cancer rat models.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Anam Shabbir, Kanwal Rehman, Muhammad Sajid Hamid Akash, Moazzama Akbar, Zunera Chaudhary, Pharkphoom Panichayupakaranant, Muhammad Ajmal Shah
Summary: This study investigated the potential efficacy of curcuminoid-rich extract (CRE) and its ternary complex (TC) in the treatment of Alzheimer's disease (AD). The results showed that CRE and TC significantly improved behavioral and biochemical parameters, as well as acetylcholinesterase inhibitory activity. Histological analysis indicated that these supplements stabilized neurodegenerative changes and neuronal loss. Furthermore, CRE and TC supplementation downregulated the expression of pathological genes associated with AD. These findings suggest that CRE and TC may act as promising candidates for the prevention of AD through multiple underlying signaling pathways.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Sumbal Rasheed, Kanwal Rehman, Muhammad Ibrahim, Muhammad Imran, Mohammed A. Assiri
Summary: Krupple-Like family of transcription factor-14 (KLF14) is a crucial gene involved in various biological functions and pathological mechanisms. It controls the expression of multiple genes and influences lipid metabolism, glucose regulation, insulin sensitivity, as well as cell apoptosis, proliferation, and differentiation. KLF14 has also been used as an epigenetic biomarker for estimating chronological age. Genetic variations in KLF14, especially in adipose tissues, are associated with dyslipidemia, insulin resistance, and glucose intolerance. The prevalence of these genetic polymorphisms varies among different populations due to ethnic differences and epigenetic modifications, and they can be influenced by environmental and physiological factors such as diet, age, gender, and obesity.
Article
Medicine, Research & Experimental
Muhammad Tariq, Nadia Hussain, Kanwal Rehman, Muhammad Sajid Hamid Akash, Amal H. I. Al Haddad, Amira S. A. Said, Adel Al Fateasej, Ali Alamri, Awaji Y. Safhi, Fahad Y. Sabei, Ahmed Abdullah Al Awad, Musaddique Hussain
Summary: In this study, it was found that lapatinib effectively suppressed the expression of IL_13-induced M2 polarized macrophages surface markers and downregulated M2 genes related to tumor progression. Lapatinib also inhibited the invasion and migration of cancer cells mediated by M2 polarized macrophages. Mechanistically, lapatinib inhibited IL-13 triggered STAT6 phosphorylation. In the mouse model, lapatinib significantly reduced tumorigenesis and downregulated M2 markers in the tumor.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Francis Victor, Kanwal Rehman, Muhammad Sajid Hamid Akash, Sumbal Rasheed, Muhammad Imran, Mohammed Ali Assiri
Summary: Omega-3 fatty acids are important dietary components necessary for normal growth and development. They possess therapeutic activities against various diseases but are prone to oxidation, reducing their efficacy. To overcome this problem, novel drug delivery approaches have been developed to enhance stability and maximize therapeutic potential of omega-3 fatty acids.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Endocrinology & Metabolism
Abdullah Salah Alanazi, Sumbal Rasheed, Kanwal Rehman, Tauqeer Hussain Mallhi, Muhammad Sajid Hamid Akash, Nasser Hadal Alotaibi, Abdulaziz Ibrahim Alzarea, Nida Tanveer, Yusra Habib Khan
Summary: This study investigates the relationship between KLF14 rs4731702 single nucleotide polymorphism (SNP) and the risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in different ethnic populations. The findings suggest that individuals with the C allele of KLF14 rs4731702 exhibit compromised insulin sensitivity, decreased HDL-C and ApoA1 levels, and increased serum glucose, TG, and LDL-C concentrations in T2DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tauqeer Hussain Mallhi, Momina Shahid, Kanwal Rehman, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Muhammad Sajid Hamid Akash, Muhammad Hammad Butt
Summary: Myocardial infarction (MI) is a cardiovascular disease caused by coronary artery blockage, leading to cardiac muscle death. The etiology of MI involves environmental, occupational, and genetic factors. Previous studies have shown that different variants of the MTHFR gene are responsible for MI by impacting folate and homocysteine metabolism. This study focuses on investigating the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor. The study found that the T/T homozygous genotype of MTHFR C677T (rs1801133) was significantly associated with MI in patients with DM as a risk factor.
Article
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Mutayyba Fatima, Kanwal Rehman, Qudsia Rehman, Zunera Chauhdary, Ahmed Nadeem, Tahir Maqbool Mir
Summary: The aim of this study was to investigate the disruptions of metabolic pathways induced by bisphenol A (BPA) and explore the potential therapeutic intervention provided by resveratrol (RSV) in mitigating these disruptions through the modulation of biochemical pathways. The results revealed that BPA exposure significantly increased the serum levels of various biomarkers and gene expressions associated with metabolic disorders, while RSV treatment effectively reduced these alterations and restored normal metabolic function. The findings suggest that RSV shows promise as a therapeutic intervention for BPA-induced metabolic disorders.
Article
Biochemistry & Molecular Biology
Syed Muhammad Shoaib, Samina Afzal, Ali Feezan, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: Our study investigated the effects of arsenic-induced metabolic disorders, specifically disruptions in lipid metabolism, amino acid metabolism, and carbohydrate metabolism. We also assessed the potential therapeutic effects of resveratrol as a remedy for arsenic-induced diabetes. The findings showed significant changes in glucose levels, insulin resistance, inflammatory biomarkers, and liver and kidney function in mice exposed to arsenic. Additionally, enzyme levels related to carbohydrate metabolism and oxidative stress biomarkers were reduced in the arsenic-exposed group. The study also observed alterations in gene expression related to lipid and carbohydrate metabolism, as well as decreases in certain amino acids in arsenic-exposed mice. Metabolomics analysis identified disruptions in lipid metabolomes, amino acids, and arsenic metabolites. Histopathological observations revealed significant changes in liver architecture in the arsenic-exposed group.
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Azka Yaqoob, Kanwal Rehman, Muhammad Imran, Mohammed A. A. Assiri, Fatema Al-Rashed, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: Heavy metals are highly toxic compounds found in the earth's crust. Their environmental levels are consistently rising above permissible limits, causing disruption of metabolism and altered gene or protein expression. Metabolomics, a state-of-the-art analytical tool, is used to investigate the mechanisms of metabolic impairment caused by heavy metal toxicities. It plays a key role in identifying perturbations in lipid and amino acid metabolism and oxidative stress in metabolic impairment. The applications of metabolomics in meeting emerging needs are discussed.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: This study aimed to investigate the potential protective effects of metformin and vitamin E against AlCl3-induced neuroinflammation and cardiometabolic disturbances. The results showed that the combination therapy of metformin and vitamin E significantly reduced glucose, cholesterol, and triglyceride levels and increased insulin and high-density lipoprotein levels. Moreover, the combination therapy preserved neuronal structures and normal morphology in brain, heart, and pancreatic tissues.
Article
Chemistry, Multidisciplinary
Mohammed A. Assiri, Akbar Ali, Muhammad Ibrahim, Muhammad Usman Khan, Khalid Ahmed, Muhammad Sajid Hamid Akash, Muhammad Akhtar Abbas, Athar Javed, Muhammad Suleman, Muhammad Khalid, Ishtiaq Hussain
Summary: The synthesis of three lauric acid-based hydrazones was carried out and their antioxidant and anticancer activities were evaluated. The results showed that NBDH exhibited the highest antioxidant activity, while FBDH showed the highest anticancer activity. Molecular simulation analysis confirmed the potential of these compounds for biological, electronic, and nonlinear optical applications.
Review
Chemistry, Multidisciplinary
Muhammad Sajid Hamid Akash, Sumbal Rasheed, Kanwal Rehman, Muhammad Imran, Mohammed A. Assiri
Summary: This article discusses the harmful effects of bisphenols on various body systems and mechanisms, as well as their biotransformation processes in organisms and ecosystems. It emphasizes preventive measures to avoid bisphenol exposure and highlights the potential use of plant-based bioactive compounds as therapeutic strategies. The findings contribute to a better understanding of bisphenol research and the development of safer practices and interventions to safeguard public health.
Article
Environmental Sciences
Muhammad Sajid Hamid Akash, Moazzama Akbar, Kanwal Rehman, Muhammad Ajmal Shah, Pharkphoom Panichayupakaranant, Muhammad Imran, Mohammed A. Assiri
Summary: Currently, only a few cholinesterase inhibitor drugs are effective in relieving symptoms of Alzheimer's disease (AD), but they do not treat the underlying causes and have adverse effects. Berberine has shown therapeutic potential against AD, and this study evaluated its activity in an AD rat model. The results showed that both pure berberine (PB) and berberine-enriched extract (BEE) had neuroprotective effects and improved cognitive function in the rats, suggesting their potential as treatments for AD. However, further clinical trials are needed to assess their efficacy and safety.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Kanwal Rehman, Ammara Afzaal, Muhammad Sajid Hamid Akash, Muhammad Imran, Mohammed A. Assiri
Summary: The self-regulation mechanism of the cytokine channel involves the synthesis of antagonistic cytokines that connect to receptors and release soluble cytokine receptors. Interleukin-1 receptor antagonist (IL-1Ra) is the first naturally occurring receptor antagonist of cytokine. IL-1Ra protein is obtained from cultured monocyte supernatants. IL-1 family includes IL-1a, IL-1β, and IL-1Ra. IL-Ra is involved in normal physiological functions and acts as an anti-inflammatory agent. IL-Ra is synthesized in tissues during active disease and can be measured or estimated. Maintenance of IL-Ra and IL-1 levels is crucial for host resistance during diseased conditions. This article focuses on the synthesis and functions of IL-Ra in activated inflammatory responses.
Article
Biology
Momina Shahid, Kanwal Rehman, Muhammad Sajid Hamid Akash, Haleem Suhail, Sumbal Rasheed, Muhammad Imran, Mohammed A. Assiri
Summary: Genetic polymorphism plays a vital role in the pathogenesis and development of myocardial infarction (MI), as a single nucleotide polymorphism in an amino acid sequence can lead to a diseased state. Multiple positions within a single gene can exhibit genetic polymorphism, resulting in different variants. Genetic polymorphisms of AGT M235T, AGT T174M, ACE I/D, eNOS, and MTHFR can be risk factors for MI. However, it is crucial to investigate the prevalence of these genetic polymorphisms in different populations.
