Article
Chemistry, Medicinal
Zi-Lin Hou, Feng-Ying Han, Li-Li Lou, Wen-Yu Zhao, Xiao-Xiao Huang, Guo-Dong Yao, Shao-Jiang Song
Summary: Cumulative evidence suggests that the dysfunction of mitochondria plays a crucial role in tumor treatment. In this study, it was found that dehydrocrenatidine (DEC) exhibits a promising inhibitory effect on the growth of hepatocellular carcinoma (HCC) cells by inducing apoptosis. DEC targets and regulates the function of mitochondrial complexes, affecting oxidative phosphorylation and ultimately leading to mitochondrial dysfunction. The combination of DEC and sorafenib also shows a synergistic effect.
PHYTOTHERAPY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Nivea Dias Amoedo, Saharnaz Sarlak, Emilie Obre, Pauline Esteves, Hugues Begueret, Yann Kieffer, Benoit Rousseau, Alexis Dupis, Julien Izotte, Nadege Bellance, Laetitia Dard, Isabelle Redonnet-Vernhet, Giuseppe Punzi, Mariana Figueiredo Rodrigues, Elodie Dumon, Walid Mafhouf, Veronique Guyonnet-Duperat, Lara Gales, Tony Palama, Floriant Bellvert, Nathalie Dugot-Senan, Stephane Claverol, Jean-Marc Baste, Didier Lacombe, Hamid Reza Rezvani, Ciro Leonardo Pierri, Fatima Mechta-Grigoriou, Matthieu Thumerel, Rodrigue Rossignol
Summary: Metabolic reprogramming in cancer is characterized by different mitochondrial respiration levels in lung adenocarcinoma patients. Tumors with high mitochondrial respiration exhibit distinct metabolic and growth patterns compared to tumors with low mitochondrial respiration. The drug trimetazidine can reduce tumor growth by inhibiting the mitochondrial trifunctional fatty acid oxidation enzyme in tumors.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Yangyang Li, Anqi Zhang, Kuayue Li, Dahai Zhao, Feng Li, Songyan Liao, Yunting Zhang, Yan Huang
Summary: In this study, the researchers investigated the promoting effect of ASIC1a on LPS-induced ALI and its mechanisms. They found that ASIC1a induces apoptotic response in ALI through mitochondrial apoptosis. Pretreatment with the ASIC1a specific blocker PcTx-1 inhibited both the pathological changes of ALI and lung dysfunction. PcTx-1 also reduced the expression of apoptosis-related proteins and reversed the changes in mitochondrial membrane potential and calcium influx.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Xishuai Tong, Xiaohui Fu, Gengsheng Yu, Huayi Qu, Hui Zou, Ruilong Song, Yonggang Ma, Yan Yuan, Jianchun Bian, Jianhong Gu, Zongping Liu
Summary: Cadmium (Cd) is a harmful environmental heavy metal that accumulates in the body and causes various health problems. Polystyrene (PS), a type of microplastic, also has toxic effects. The study aimed to investigate the effects of PS on Cd-induced mitochondrial damage in the lungs of mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuting Lin, Qingdi Lu, Chaolei Chen, Beibei Wang, Lisha Guo, Jingwen Xie, Chengshui Chen, Lili Huang, Li Dong
Summary: The study showed that compound 39 has anti-inflammatory, antioxidant, and anti-apoptotic activities against LPS-induced acute lung injury, possibly through suppression of the MAPK/NF-κB pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiacui Xie, He Wang, Qiudi Huang, Jiachang Lin, Huaying Wen, Yingling Miao, Le Lv, Dongxue Ruan, Xiyong Yu, Linghao Qin, Yi Zhou
Summary: In this study, a prodrug camptothecin-triphenylphosphine modified with hyaluronic acid was used to deliver the drug into mitochondria, leading to disruption of mitochondrial structure and function, increased apoptosis of lung cancer cells, and inhibition of tumor growth.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Reem J. Abdualmjid, Consolato M. Sergi
Summary: This study investigated the anti-tumor effects of thymoquinone (TQ), derived from Nigella sativa, on hepatocellular carcinoma and cholangiocarcinoma. The results showed that TQ suppressed cell proliferation and induced apoptosis, suggesting its potential as a therapeutic agent for these types of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Ahmed Al Saqr, El-Sayed Khafagy, Mohammed F. Aldawsari, Khaled Almansour, Amr S. Abu Lila
Summary: Furanodienone (FDN), a bioactive compound derived from Rhizoma Curcumae, has been shown to possess anticancer properties against lung cancer. This study found that FDN inhibits the proliferation of lung cancer cells and induces apoptosis by disrupting nuclear morphology and activating caspase-9 and caspase-3. FDN also induces cell cycle arrest and downregulates the Wnt signaling pathway. These findings suggest that FDN may serve as a promising adjuvant therapy for lung cancer.
Article
Oncology
Lin Che, Jia-Shen Wu, Ze-Bang Du, Yu-Qiao He, Lei Yang, Jin-Xian Lin, Zhao Lei, Xiao-Xuan Chen, Dong-Bei Guo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Summary: Translation: New therapeutic strategies are needed to improve the anti-cancer effect for hepatocellular carcinoma (HCC). This study explores the involvement of mitochondrial translocation of cyclooxygenase-2 (COX-2) in mitochondrial dynamics and sensitization of HCC cells to anti-tumor therapy. The findings suggest that targeting mitochondrial COX-2 could be a potential therapeutic approach for HCC and other cancers with high expression of COX-2.
Article
Biochemistry & Molecular Biology
Kate L. Hertweck, Kunwar S. Vikramdeo, Jose N. Galeas, Stephen M. Marbut, Paramahansa Pramanik, Furhan Yunus, Seema Singh, Ajay P. Singh, Santanu Dasgupta
Summary: In this study, the authors identified a unique set of mitochondria-targeted genes that are differentially expressed in non-small-cell lung cancer subtypes. Altered expression of certain genes, such as SLC25A4, was associated with poor patient survival. These findings highlight the potential of these genes as biomarkers and therapeutic targets for lung cancer.
Article
Chemistry, Multidisciplinary
Zitong Yu, Chao Zhao, Shi Hu, Huitao Zhang, Wenbo Li, Renjie Zhang, Qian Luo, Hui Yang
Summary: This study investigated and optimized critical experimental conditions for EV protein profiling using a human lung carcinoma cell line, combining differential ultracentrifugation and MALDI-TOF MS. Results showed that medium components and ultracentrifugation procedures play important roles in mass spectrometry detection. The study demonstrated the potential of MALDI-TOF MS-based EV analysis with optimized protocols for rapid screening of protein biomarkers associated with early cancer diagnosis.
Article
Multidisciplinary Sciences
Mohammad Naimul Islam, Galina A. Gusarova, Shonit R. Das, Li Li, Eiji Monma, Murari Anjaneyulu, Liberty Mthunzi, Sadiqa K. Quadri, Edward Owusu-Ansah, Sunita Bhattacharya, Jahar Bhattacharya
Summary: Inhalation of pathogens causing acute lung injury (ALI) leads to high mortality. This study reveals that loss of the mitochondrial calcium uniporter (MCU) in alveolar type 2 cells (AT2) impairs mitochondrial calcium buffering and surfactant secretion, resulting in increased mortality in response to LPS instillation. MCU could be a potential therapeutic target for ALI.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Hui Yao, Siyu Zhang, Haijing Xie, Yue Fan, Mengyu Miao, Rui Zhu, Ling Yuan, Miao Gu, Yiwen You, Bo You
Summary: Objective: The study investigates the molecular mechanism underlying Nasopharyngeal carcinoma (NPC) and finds that dysregulation of calcium homeostasis and calcium-binding proteins can contribute to the malignancy of tumors. Specifically, the study shows that RCN2 promotes malignancy through Ca2+ flow imbalance, leading to stress-mediated mitochondrial apoptosis. Upstream regulators YY1 and GSC are also identified, suggesting their potential role in the development of NPCs.
Article
Biochemistry & Molecular Biology
Yi Guo, Quan Li, Rongmu Xia, Chuanshu Cai
Summary: Farrerol has anti-tumor effects on lung adenocarcinoma cells by inducing apoptosis and cell cycle arrest, without significant impact on normal lung epithelial cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)