Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
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Title
Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
Authors
Keywords
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Journal
CNS DRUGS
Volume 37, Issue 5, Pages 399-440
Publisher
Springer Science and Business Media LLC
Online
2023-05-12
DOI
10.1007/s40263-023-01007-6
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- Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25–35 peptide-injected mice, a nontransgenic Alzheimer’s disease model
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- Monoclonal antibody therapies for the treatment of relapsing-remitting multiple sclerosis: differentiating mechanisms and clinical outcomes
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- Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime
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- Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
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- Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
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- Autophagy and human disease: emerging themes
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- Effects of dextromethorphan on glial cell function: Proliferation, maturation, and protection from cytotoxic molecules
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- Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis
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- NMDA Receptors Are Upregulated and Trafficked to the Plasma Membrane after Sigma-1 Receptor Activation in the Rat Hippocampus
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- Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial
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- Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics
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- The phenotypic variability of amyotrophic lateral sclerosis
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- Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?
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- Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity
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- Olfactory Dysfunction Predicts 5-Year Mortality in Older Adults
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- Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with 11C-SA4503 and microPET
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- Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances
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- The neuroprotective and neurotrophic agent T-817MA for Alzheimer’s disease: Randomized, double-blind, placebo-controlled proof-of-concept trial outcomes
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- Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
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- Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer
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- Evaluating the effects of amantadin, modafinil and acetyl-l-carnitine on fatigue in multiple sclerosis – result of a pilot randomized, blind study
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- Sigma-1 Receptor Knockout Impairs Neurogenesis in Dentate Gyrus of Adult HippocampusViaDown-Regulation of NMDA Receptors
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- Mechanism of action of ketamine
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- The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer's disease
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- Sigma 1 receptor: A new therapeutic target for pain
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- Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression
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- Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression
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- Sigma-2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy
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- A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease
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- Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
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- Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease
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- Lack of sigma-1 receptor exacerbates ALS progression in mice
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- Treatment of Huntington’s Disease
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- Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival
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- Ketamine prevents stress-induced cognitive inflexibility in rats
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- Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway
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- Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy
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- Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments
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- Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands
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- Ketamine for Treatment-Resistant Unipolar Depression
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- The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines
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- The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements
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- The dopaminergic stabilizer pridopidine decreases expression of l-DOPA-induced locomotor sensitisation in the rat unilateral 6-OHDA model
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- Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells
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- Dextromethorphan Abuse Leading to Assault, Suicide, or Homicide
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- Brain Activity Mapping in Mecp2 Mutant Mice Reveals Functional Deficits in Forebrain Circuits, Including Key Nodes in the Default Mode Network, that are Reversed with Ketamine Treatment
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- NADPH Oxidase 1 Mediates -Synucleinopathy in Parkinson's Disease
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- Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice
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- Comparison of the effect of aspirin and amantadine for the treatment of fatigue in multiple sclerosis: a randomized, blinded, crossover study
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- Amantadine: The journey from fighting flu to treating Parkinson disease
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- Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N′-dimethyltryptamine forming enzyme, indole-N-methyl transferase
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- Association between a variant of the sigma-1 receptor gene and Alzheimer's disease
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- Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice
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- Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease
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- Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression
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- A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis
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- Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease
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- Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor
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- Dextromethorphan/Quinidine
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- Genetic Polymorphisms in Sigma-1 Receptor and Apolipoprotein E Interact to Influence the Severity of Alzheimers Disease
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- Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo
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- Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection
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- Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model
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- Energy deficit in Huntington disease: why it matters
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- Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury
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- Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
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- Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord
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- Dextromethorphan Plus Ultra Low-Dose Quinidine Reduces Pseudobulbar Affect
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- The Effect of Donepezil Treatment on Cardiovascular Mortality
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- BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice
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- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
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- Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative
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- Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial
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- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
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- DHEA prevents Aβ25–35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling
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- The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study
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- A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis
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- Alzheimer's Disease
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- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
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- Memantine for non-motor features of Parkinson’s disease: A double-blind placebo controlled exploratory pilot trial
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- Hyperphosphorylated tau in the brains of mice and monkeys with long-term administration of ketamine
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- The Utility of Ketamine for the Preoperative Management of a Patient with Parkinson’s Disease
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- The relation between inflammation and neurodegeneration in multiple sclerosis brains
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- Effects of donepezil on amyloid-β and synapse density in the Tg2576 mouse model of Alzheimer's disease
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- T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-β peptide
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- Dextromethorphan-induced serotonin syndrome
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- The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids
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- Effects of PRX-00023, a Novel, Selective Serotonin 1A Receptor Agonist on Measures of Anxiety and Depression in Generalized Anxiety Disorder
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- Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
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- Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells
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- Randomized controlled trial of memantine in dementia associated with Parkinson's disease
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- Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias
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- Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons
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- Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury
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- Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway
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- The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
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- Low density of sigma1 receptors in early Alzheimer’s disease
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- Balancing Structure and Function at Hippocampal Dendritic Spines
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- Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study
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- Memantine Treatment in Patients with Mild to Moderate Alzheimers Disease Already Receiving a Cholinesterase Inhibitor: A Randomized, Double-Blind, Placebo-Controlled Trial
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- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
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- Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study
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- Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
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- MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively
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- Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus
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- Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways
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- Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: Role of sigma-1 receptors and IP3 receptors
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- Priming for l-dopa-induced dyskinesia in Parkinson’s disease: A feature inherent to the treatment or the disease?
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- Impact of fluoxetine on the human brain in multiple sclerosis as quantified by proton magnetic resonance spectroscopy and diffusion tensor imaging
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- MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
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